Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Alexandra Nicou"'
1
Epidermal Growth Factor Receptor Signaling in Hepatocellular Carcinoma: Inflammatory Activation and a New Intracellular Regulatory Mechanism
Autor: Fernando J. Corrales, M. Ujue Latasa, Maria J. Perugorria, Oihane Garcia-Irigoyen, Jesús Prieto, Alexandra Nicou, Raquel Urtasun, Carmen Berasain, Juan A. Recio, Fabiana Salis, Matías A. Avila, María P. Elizalde
Publikováno v: Digestive Diseases. 30:524-531
Background/Aims: Hepatocellular carcinoma (HCC) is a chemoresistant tumor strongly associated with chronic hepatitis. Identification of molecular links connecting inflammation with cell growth/survival, and characterization of pro-tumorigenic intrace
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a973775215ba5970ac7bc595d6a40f74
https://doi.org/10.1159/000341705
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2
Pontin and Reptin, Two Related ATPases with Multiple Roles in Cancer
Autor: Otmar Huber, Alexandra Nicou, Valérie Haurie, Danièle Taras, Ludovic Ménard, Jean Rosenbaum
Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2008, 68 (17), pp.6873-6. ⟨10.1158/0008-5472.CAN-08-0547⟩
Studies in model organisms or cultured human cells suggest potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin. Both proteins are associated with several chromatin-remodeling complexes and have many functions including tra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae809c27ee02b4cbc4c2be465a75ae9
https://doi.org/10.1158/0008-5472.can-08-0547
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3
Remodelling of calcium signalling during liver regeneration in the rat
Autor: Gilles Guillon, Thierry Tordjmann, Mauricette Hilly, Valérie Serrière, Alexandra Nicou, Sylvie Prigent, Laurent Combettes
Publikováno v: Journal of Hepatology. 46:247-256
Background/Aims During liver regeneration, a network of cytokines and growth factors interact with hepatocytes, helping to restore the liver mass and functions after partial tissue loss. Agonists that trigger Ca 2+ signals in the liver contribute to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d0d18b994e3c83f100c846bc46fd6e
https://doi.org/10.1016/j.jhep.2006.08.014
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4
Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis
Autor: Michelle Gigou, Alexandra Nicou, Isabelle Doignon, Daniel Azoulay, Isabelle Garcin, Marie-Christine Gillon, Gérard Alonso, Thierry Tordjmann, Lydie Humbert, Jean-Charles Duclos-Vallée, Boris Julien, Didier Samuel, Dominique Rainteau, Valérie Serriere-Lanneau, Denis Castaing, François Monnet
Publikováno v: Journal of Hepatology
Journal of Hepatology, Elsevier, 2011, 54 ((3)), pp.481-8. 〈10.1016/j.jhep.2010.07.012〉
Journal of Hepatology, Elsevier, 2011, 54 ((3)), pp.481-8. ⟨10.1016/j.jhep.2010.07.012⟩
Journal of Hepatology, 2011, 54 ((3)), pp.481-8. ⟨10.1016/j.jhep.2010.07.012⟩
ResearcherID
International audience; BACKGROUND & AIMS: Early neuroendocrine pathways contribute to liver regeneration after partial hepatectomy (PH). We investigated one of these pathways involving acute cholestasis, immediate portal hyperpressure, and arginine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa33cbb40d109dded478153e4cea2faf
https://pubmed.ncbi.nlm.nih.gov/21084132
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5
Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism
Autor: Jean Rosenbaum, Philippe Metzler, Hervé Prats, Christian Touriol, Jessica Zucman-Rossi, Paulette Bioulac-Sage, Alexandra Nicou, Patrick Lestienne, Jérémy Fernandez, Danièle Taras, Ludovic Ménard, Valérie Haurie, Charles Balabaud
Publikováno v: Hepatology
Hepatology, Wiley-Blackwell, 2009, 50 (6), pp.1871-83. 〈10.1002/hep.23215〉
Hepatology, Wiley-Blackwell, 2009, 50 (6), pp.1871-83. ⟨10.1002/hep.23215⟩
Hepatology, 2009, 50 (6), pp.1871-83. ⟨10.1002/hep.23215⟩
International audience; Reptin and Pontin are related ATPases associated with stoichiometric amounts in several complexes involved in chromatin remodeling, transcriptional regulation, and telomerase activity. We found that Reptin was up-regulated in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae1c59ad0ab57d4e4a5adbee0667268
http://www.hal.inserm.fr/inserm-00408518/document
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6
ATP release after partial hepatectomy regulates liver regeneration in the rat
Autor: Daniel Azoulay, Alexandra Nicou, Andres Hernandez-Garcia, Laura Lagoudakis, Jean-Charles Duclos-Vallée, Isabelle Doignon, Thierry Tordjmann, Denis Castaing, Emmanuel Gonzales, Valérie Serriere-Lanneau, Samir S. Awad, Boris Julien, Sundararajah Thevananther, Didier Samuel, Isabelle Garcin, Laurent Combettes
Publikováno v: ResearcherID
Background & Aims Paracrine interactions are critical to liver physiology, particularly during regeneration, although physiological involvement of extracellular ATP, a crucial intercellular messenger, remains unclear. The physiological release of ATP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a542c0edf35fd0e86b6d55e31392817a
https://europepmc.org/articles/PMC3625734/
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7
In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence
Autor: Danièle Taras, Nathalie Dugot-Senant, Jean Rosenbaum, Benoit Rousseau, Ludovic Ménard, Pierre Costet, Aude Grigoletto, Valérie Haurie, Alexandra Nicou
Publikováno v: Journal of hepatology. 52(5)
Background & Aims We previously showed that Reptin is overexpressed in hepatocellular carcinoma (HCC), and that in vitro depletion of Reptin with siRNAs led to HCC cell growth arrest and apoptosis. Here, we asked whether in vivo targeting of Reptin i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c617bdd668ccf49ea98dfc353ef6368
https://pubmed.ncbi.nlm.nih.gov/20334944
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8
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis
Autor: Maria Giovanna Zagami, Carmen Berasain, M. Ujue Latasa, M.J. Perugorria, Alexandra Nicou, Umberto Vespasiani-Gentilucci, Matías A. Avila, Hugo Cartagena-Lirola, Sophie Lotersztajn, Saioa Goñi, Josefa Castillo, Jesús Prieto
Publikováno v: Hepatology (Baltimore, Md.). 48(4)
The hepatic wound-healing response to chronic noxious stimuli may lead to liver fibrosis, a condition characterized by excessive deposition of extracellular matrix. Fibrogenic cells, including hepatic stellate cells and myofibroblasts, are activated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ba2bcdea2eec89d228209064f9f90b
https://pubmed.ncbi.nlm.nih.gov/18634036
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9
Hypothalamic vasopressin release and hepatocyte Ca2+ signaling during liver regeneration: an interplay stimulating liver growth and bile flow
Autor: Sylvie Prigent, Thierry Tordjmann, Alexandra Nicou, Laurent Combettes, Gérard Alonso, Valérie Serrière, Sylviane Boucherie, Gilles Guillon
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17(13)
Liver regeneration after partial hepatectomy is a plastic process during which the mechanisms that coordinate liver mass restoration compensate one another through a complex regulatory network of cytokines, growth factors, and hormones. Vasopressin,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf259c2452d6b94c4547c6741846934b
https://pubmed.ncbi.nlm.nih.gov/14519667
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