Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexandra Nazzari"'
Autor:
Yongping Yang, Wei Shi, Olubukola M. Abiona, Alexandra Nazzari, Adam S. Olia, Li Ou, Emily Phung, Tyler Stephens, Yaroslav Tsybovsky, Raffaello Verardi, Shuishu Wang, Anne Werner, Christina Yap, David Ambrozak, Tatsiana Bylund, Tracy Liu, Richard Nguyen, Lingshu Wang, Baoshan Zhang, Tongqing Zhou, Gwo-Yu Chuang, Barney S. Graham, John R. Mascola, Kizzmekia S. Corbett, Peter D. Kwong
Publikováno v:
Vaccines, Vol 9, Iss 2, p 73 (2021)
The COVID-19 pandemic highlights an urgent need for vaccines that confer protection from SARS-CoV-2 infection. One approach to an effective COVID-19 vaccine may be through the display of SARS-CoV-2 spikes on the surface of virus-like particles, in a
Externí odkaz:
https://doaj.org/article/fc8fb9e0e50a4decb6bc1527608e835d
Autor:
Martin R. Gaudinski, Lauren A. Chang, Laura Novik, Stephen D. Schmidt, Nicole A. Doria-Rose, John R. Mascola, Ingelise J. Gordon, Avan Antia, Mario Roederer, Amy R. Henry, Rachel L. Davis, Farida Laboune, Tyler Stephens, Barney S. Graham, Olubukola M. Abiona, Christian Hatcher, Kizzmekia S. Corbett, Sandeep Narpala, Chaim A. Schramm, Yi Zhang, Danielle A. Wagner, Samuel Darko, Evan M. Cale, Chloe Adrienna Talana, Kwanyee Leung, Yaroslav Tsybovsky, Nancy J. Sullivan, Lingshu Wang, Alicia T. Widge, Sijy O'Dell, Ralph S. Baric, Christopher D. Stringham, Anthony T. DiPiazza, Adam S. Olia, Sabrina Helmold Hait, Daniel C. Douek, Tongqing Zhou, Emily Phung, Amarendra Pegu, Eun Sung Yang, Peter D. Kwong, Tandile Hermanus, Penny L. Moore, David R. Martinez, Prudence Kgagudi, Sarah O’Connell, Misook Choe, Tracy Liu, Adrian B. McDermott, Alexandra Nazzari, Rosemarie D. Mason, Baoshan Zhang, Olamide K. Oloniniyi, Wei Shi, John Misasi, Julie E. Ledgerwood, Tracy J. Ruckwardt, I-Ting Teng
Publikováno v:
Science. 373
IC80 1.5 to 34.5 nanograms per milliliter). We define the structural and functional determinants of binding for all four VOC-targeting antibodies and show that combinations of two antibodies decrease the in vitro generation of escape mutants, suggest
Autor:
Tyler Stephens, Yaroslav Tsybovsky, Tracy Liu, Shuishu Wang, Tongqing Zhou, Baoshan Zhang, Alexandra Nazzari, Peter D. Kwong, Cuiping Liu, Wing-Pui Kong, Yi Zhang, Eun Sung Yang, John R. Mascola, Lingshu Wang, Kwan Leung, I-Ting Teng, Steven J. Chen, Li Ou, Adam S. Olia
Publikováno v:
The Journal of Biological Chemistry
The SARS-CoV-2 spike is the primary target of virus-neutralizing antibodies and critical to the development of effective vaccines against COVID-19. Here, we demonstrate that the prefusion-stabilized two-proline "S2P" spike -widely employed for labora
Autor:
Lingshu Wang, Tongqing Zhou, Yi Zhang, Eun Sung Yang, Chaim A. Schramm, Wei Shi, Amarendra Pegu, Olamide K. Oloninyi, Amy Ransier, Samuel Darko, Sandeep R. Narpala, Christian Hatcher, David R. Martinez, Yaroslav Tsybovsky, Emily Phung, Olubukola M. Abiona, Evan M. Cale, Lauren A. Chang, Kizzmekia S. Corbett, Anthony T. DiPiazza, Ingelise J. Gordon, Kwanyee Leung, Tracy Liu, Rosemarie D. Mason, Alexandra Nazzari, Laura Novik, Adam S. Olia, Nicole A. Doria-Rose, Tyler Stephens, Christopher D. Stringham, Chloe Adrienna Talana, I-Ting Teng, Danielle Wagner, Alicia T. Widge, Baoshan Zhang, Mario Roederer, Julie E. Ledgerwood, Tracy J. Ruckwardt, Martin R. Gaudinski, Ralph S. Baric, Barney S. Graham, Adrian B. McDermott, Daniel C. Douek, Peter D. Kwong, John R Mascola, Nancy J. Sullivan, John Misasi
Publikováno v:
bioRxiv
The emergence of highly transmissible SARS-CoV-2 variants of concern (VOC) that are resistant to therapeutic antibodies highlights the need for continuing discovery of broadly reactive antibodies. We identify four receptor-binding domain targeting an
Autor:
Raffaello Verardi, Emily Phung, David R. Ambrozak, Wei Shi, Peter D. Kwong, Christina Yap, Tracy Liu, Adam S. Olia, Olubukola M. Abiona, Yaroslav Tsybovsky, Baoshan Zhang, Anne P. Werner, Gwo-Yu Chuang, Tongqing Zhou, Kizzmekia S. Corbett, Tyler Stephens, Tatsiana Bylund, Alexandra Nazzari, Richard Nguyen, Li Ou, John R. Mascola, Yongping Yang, Barney S. Graham, Shuishu Wang, Lingshu Wang
Publikováno v:
Vaccines, Vol 9, Iss 73, p 73 (2021)
Vaccines
Volume 9
Issue 2
Vaccines
Volume 9
Issue 2
The COVID-19 pandemic highlights an urgent need for vaccines that confer protection from SARS-CoV-2 infection. One approach to an effective COVID-19 vaccine may be through the display of SARS-CoV-2 spikes on the surface of virus-like particles, in a
Autor:
Jonathan Stuckey, Pengfei Wang, Jason Gorman, Mallika Sastry, Phinikoula S. Katsamba, Wei Shi, Alexandra Nazzari, Micah Rapp, Arne Schön, Tyler Stephens, David D. Ho, Jude Bimela, Yaroslav Tsybovsky, Shuishu Wang, Tongqing Zhou, Lawrence Shapiro, John R. Mascola, Jeffrey C. Boyington, Gwo-Yu Chuang, Adam S. Olia, I-Ting Teng, Richard A. Friesner, Baoshan Zhang, Jared M. Sampson, Gabriele Cerutti, Peter D. Kwong
Publikováno v:
Cell Host & Microbe
bioRxiv
bioRxiv
The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the human ACE2 receptor and to facilitate virus entry, which can occur through low-pH-endosomal pathways. To understand how ACE2 binding and low pH affect spike conformatio
Autor:
Baoshan Zhang, Jared M. Sampson, Lawrence Shapiro, Alexandra Nazzari, Tyler Stephens, Yaroslav Tsybovsky, John R. Mascola, I-Ting Teng, Phinikoula S. Katsamba, Jason Gorman, Gabriele Cerutti, Micah Rapp, Tongqing Zhou, Peter D. Kwong, Mallika Sastry, Wei Shi, Gwo-Yu Chuang, Jude Bimela, Shuishu Wang, Arne Schön, Jonathan Stuckey, David D. Ho, Pengfei Wang, Richard A. Friesner, Adam S. Olia, Jeffrey C. Boyington
Publikováno v:
SSRN Electronic Journal.
The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the ACE2 receptor and to facilitate virus entry. But what controls RBD positioning? As SARS-CoV-2 utilizes endosomal pathways as a major mode of entry, we investigated the
Autor:
Irene M. Francino Urdániz, Timothy A. Whitehead, Ahmed S. Fahad, Bailey B. Banach, Adam S. Olia, Phinikoula S. Katsamba, Sheila N. Lopez Acevedo, Lihong Liu, Manoj S. Nair, Alexandra Nazzari, Yaoxing Huang, Jacy R. Wolfe, Amy D. Laflin, Bharat Madan, Xiaoli Pan, Matheus Oliveira de Souza, Jude Bimela, David D. Ho, Pengfei Wang, Kwok-Yung Yuen, I-Ting Teng, Jian Yu, Yaroslav Tsybovsky, Eswar R. Reddem, Rajani Nimrania, Lawrence Shapiro, Brandon J. DeKosky, Gabriele Cerutti, Peter D. Kwong, Paul J. Steiner, Matias Gutiérrez-González, Yang Luo, Chen-Hsiang Shen, Tongqing Zhou
Publikováno v:
SSRN Electronic Journal.
SummaryUnderstanding protective mechanisms of antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We discovered a new antibody, 910-30, that targets the SARS-CoV-2 ACE2 receptor binding site as a member of a public
Autor:
Gabriele Cerutti, Yaroslav Tsybovsky, Bharat Madan, Bailey B. Banach, Matheus Oliveira de Souza, Adam S. Olia, Tongqing Zhou, I-Ting Teng, Yaoxing Huang, Jacy R. Wolfe, Phinikoula S. Katsamba, Peter D. Kwong, Pengfei Wang, Manoj S. Nair, Timothy A. Whitehead, Chen-Hsiang Shen, Ahmed S. Fahad, David D. Ho, Kwok-Yung Yuen, Irene M. Francino-Urdaniz, Brandon J. DeKosky, Jude Bimela, Lihong Liu, Eswar R. Reddem, Amy D. Laflin, Xiaoli Pan, Rajani Nimrania, Lawrence Shapiro, Jian Yu, Alexandra Nazzari, Sheila N. Lopez Acevedo, Paul J. Steiner, Matias Gutiérrez-González, Yang Luo
Publikováno v:
Cell Reports
bioRxiv
Cell Reports, Vol 37, Iss 1, Pp 109771-(2021)
bioRxiv
Cell Reports, Vol 37, Iss 1, Pp 109771-(2021)
Understanding mechanisms of protective antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We report a monoclonal antibody, 910-30, targeting the SARS-CoV-2 receptor-binding site for ACE2 as a member of a public ant