Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alexandra N. Wilson"'
Autor:
James Kim, Jean Y. Tang, Ervin H. Epstein, Alexandra N. Wilson, Noelle S. Williams, Alex Lee, Vinh Trang, Baozhi Chen
Supplementary Figure S1. Structures of Triazole Antifungal Drugs; Supplementary Figure S2. Verification of Drug-resistance of SMO Mutants; Supplementary Table S1. Murine Serum Pharmacokinetic Parameters; Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c73000e684e206440828c77dad0fa25
https://doi.org/10.1158/1535-7163.22508031.v1
https://doi.org/10.1158/1535-7163.22508031.v1
Autor:
James Kim, Adi F. Gazdar, Ignacio I. Wistuba, Carmen Behrens, Hui Tian, Luc Girard, Brenda C. Timmons, Paul Yenerall, Alexandra N. Wilson, Baozhi Chen, Chunli Shao, Sahba Kasiri
This file contains additional data including additional mRNA analyses of TCGA and SPORE datasets, validation of antibodies and siRNAs, ATO dose finding studies, analyses of mutations in PI3K pathway in human cancers. The file also contains 2 tables o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d9d921df0a1249fefa52109a9da125
https://doi.org/10.1158/0008-5472.22415411.v1
https://doi.org/10.1158/0008-5472.22415411.v1
Autor:
James Kim, Adi F. Gazdar, Ignacio I. Wistuba, Carmen Behrens, Hui Tian, Luc Girard, Brenda C. Timmons, Paul Yenerall, Alexandra N. Wilson, Baozhi Chen, Chunli Shao, Sahba Kasiri
Lung squamous cell carcinoma (SCC), strongly associated with smoking, is treated primarily with traditional cytotoxic chemotherapy due to a lack of FDA-approved targeted agents available. Here, we identify the Hedgehog pathway transcription factor GL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcadf4f9837a00704b436d8d135240fa
https://doi.org/10.1158/0008-5472.c.6509279.v1
https://doi.org/10.1158/0008-5472.c.6509279.v1
Publikováno v:
Methods Mol Biol
Hedgehog Signaling ISBN: 9781071617007
Hedgehog Signaling ISBN: 9781071617007
Preclinical mouse models of lung cancer have been vital experimental tools to elucidate cancer biology and test novel therapeutic regimens. Two main models are most commonly used-genetically engineered mouse models and xenograft transplantation model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401a2d92026b54a0b85140a86a7c85ca
https://europepmc.org/articles/PMC9262117/
https://europepmc.org/articles/PMC9262117/
Autor:
Luc Girard, Sahba Kasiri, Ummay Marriam, Barbara Mino, Jashkaran Gadhvi, Katherine Luby-Phelps, Annika Reczek, Baozhi Chen, Evan Noel, Wei Lu, Simbarashe Mazambani, Justin A. Bishop, Luisa M. Solis, Alexandra N. Wilson, Jung Whan Kim, James Kim
Publikováno v:
Oncogene
Activation of the Hedgehog (Hh) signaling pathway by mutations within its components drives the growth of several cancers. However, the role of Hh pathway activation in lung cancers has been controversial. Here, we demonstrate that the canonical Hh s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2515092d625b86a7b6e3ad64679fc7e5
https://doi.org/10.1101/747915
https://doi.org/10.1101/747915
GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma
Autor:
Brenda C. Timmons, Adi F. Gazdar, Alexandra N. Wilson, James Kim, Carmen Behrens, Ignacio I. Wistuba, Baozhi Chen, Paul Yenerall, Luc Girard, Sahba Kasiri, Chunli Shao, Hui Tian
Publikováno v:
Cancer research. 77(16)
Lung squamous cell carcinoma (SCC), strongly associated with smoking, is treated primarily with traditional cytotoxic chemotherapy due to a lack of FDA-approved targeted agents available. Here, we identify the Hedgehog pathway transcription factor GL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5daa8320c354e85a259b99c36bbc377
https://pubmed.ncbi.nlm.nih.gov/28652248
https://pubmed.ncbi.nlm.nih.gov/28652248
Autor:
Zhiqun Zeng, Ummay Marriam, James Kim, Luc Girard, Baozhi Chen, Sahba Kasiri, Annika Reczek, Alexandra N. Wilson
Publikováno v:
Clinical Cancer Research. 24:B03-B03
Aberrant activation of the Hedgehog (Hh) signaling pathway drives the tumor growth of Gorlin-type cancers, but its role in other epithelial cancers, including non-small cell lung cancer (NSCLC), has been controversial. We used human lung adenocarcino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06386458ea81fd1e33c86253cc8ad8d2
https://doi.org/10.1158/1557-3265.aacriaslc18-b03
https://doi.org/10.1158/1557-3265.aacriaslc18-b03
Autor:
Ervin H. Epstein, Alexandra N. Wilson, James Kim, Alexander Lee, Vinh Trang, Noelle S. Williams, Jean Y. Tang, Baozhi Chen
Publikováno v:
Molecular cancer therapeutics. 15(5)
Deregulation of Hedgehog (Hh) pathway signaling has been associated with the pathogenesis of various malignancies, including basal cell carcinomas (BCC). Inhibitors of the Hh pathway currently available or under clinical investigation all bind and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18259af00f3ee3e0f344c8e58a5488b9
https://pubmed.ncbi.nlm.nih.gov/26823493
https://pubmed.ncbi.nlm.nih.gov/26823493
Autor:
Baozhi Chen, James Kim, Umaru Barrie, Luc Girard, Alexandra N. Wilson, Ummay Marriam, Sahba Kasiri, Zhiqun Zeng
Publikováno v:
Cancer Research. 77:2964-2964
Aberrant activation of the Hedgehog (Hh) signaling pathway, a crucial developmental pathway, drives the tumor growth of Gorlin-type cancers. However, recent data suggest that paracrine activation of the pathway is tumor suppressive rather than oncoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3c1ce23fa6d7f0b7661035498b89fb
https://doi.org/10.1158/1538-7445.am2017-2964
https://doi.org/10.1158/1538-7445.am2017-2964
Autor:
Hui Tian, Ignacio I. Wistuba, James Kim, Adi F. Gazdar, Alexandra N. Wilson, Luc Girard, Chunli Shao, Suzie K. Hight, Carmen Behrens, Paul Yenerall, Baozhi Chen, Patrick Dospoy, Sahba Kasiri
Publikováno v:
Journal of Thoracic Oncology. (2):S28
Background: The Hedgehog (Hh) signaling pathway is critical for embryonic development and its deregulation is implicated in a number of tumor types. The role of the Hh signaling pathway, however, in the initiation and growth of non-small cell lung ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f244716f008b1835753f1ebede02ce