Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Alexandra N. Olson"'
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Deep mutational analysis of elongation factor eEF2 residues implicated in human disease to identify functionally important contacts with the ribosome
Autor: Alexandra N. Olson, Serena Song, Jonathan D. Dinman
Publikováno v: The Journal of biological chemistry. 299(1)
An emerging body of research is revealing mutations in elongation factor eEF2 that are implicated in both inherited and de novo neurodevelopmental disorders. Previous structural analysis has revealed that most pathogenic amino acid substitutions map
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426622037cd5caacd28dadfff9078a61
https://pubmed.ncbi.nlm.nih.gov/36470424
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4
Two Ribosomes Are Better Than One... Sometimes
Autor: Jonathan D. Dinman, Alexandra N. Olson
Publikováno v: Molecular Cell. 79:541-543
In this issue of Molecular Cell, Meydan and Guydosh present an elegant and rigorous addition to the exciting investigation of the roles played by ribosome collisions in eukaryotic translation and cellular homeostasis.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da850959122a8a9ba938b68143a77ba7
https://doi.org/10.1016/j.molcel.2020.07.022
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5
De Novo variants in EEF2 cause a neurodevelopmental disorder with benign external hydrocephalus
Autor: Rolph Pfundt, Jonathan D. Dinman, Arjan P.M. de Brouwer, Grace Yoon, Maria J. Nabais Sá, Alexandra Schneider, Michèl A.A.P. Willemsen, Graeme A.M. Nimmo, Alexandra N. Olson, Christopher M. Gomez, Bert B.A. de Vries, Francisca Millan
Publikováno v: Human Molecular Genetics, 29, 24, pp. 3892-3899
Human Molecular Genetics, 29, 3892-3899
Hum Mol Genet
Contains fulltext : 231523.pdf (Publisher’s version ) (Closed access) Eukaryotic translation elongation factor 2 (eEF2) is a key regulatory factor in gene expression that catalyzes the elongation stage of translation. A functionally impaired eEF2,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c9988ce0f17a33c6281af29dccbc50
https://hdl.handle.net/2066/231523
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6
Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)
Autor: Josue San Emeterio, Jonathan D. Dinman, Michael T. Woodside, Jamie A. Kelly, Sneha Munshi, Krishna Neupane, Lois Pollack, Alexandra N. Olson
Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry
bioRxiv
article-version (status) pre
article-version (number) 2
Approximately 17 years after the severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic, the world is currently facing the COVID-19 pandemic caused by SARS corona virus 2 (SARS-CoV-2). According to the most optimistic projections, it will
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e39aa366e33078e7e7fccb95baef12
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7
Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS-CoV-2
Autor: Josue San Emeterio, Alexandra N. Olson, Jonathan D. Dinman, Jamie A. Kelly, Sneha Munshi, Michael T. Woodside, Lois Pollack, Krishna Neupane
17 years after the SARS-CoV epidemic, the world is facing the COVID-19 pandemic. COVID-19 is caused by a coronavirus named SARS-CoV-2. Given the most optimistic projections estimating that it will take over a year to develop a vaccine, the best short
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887eade9a49395fdf5f88cc629ccfe42
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8
Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism
Autor: Marianna Penzo, Riekelt H. Houtkooper, Marjolijn C.J. Jongmans, Alexandra Nin-Velez, Carolina Marques dos Santos Vieira, Evelien Zonneveld-Huijssoon, Alexandra N. Olson, Roland P. Kuiper, Anne-Marie Hesse, Marie-Françoise O'Donohue, Marc Bierings, Hyung L. Elfrink, Michel van Weeghel, Marco Lezzerini, Manon Saby, Peter G. J. Nikkels, Alyson W. MacInnes, Lydie Da Costa, Illja J. Diets, Pierre-Emmanuel Gleizes, Jonathan D. Dinman, Marc Gastou, Lorenzo Montanaro, Yohann Couté, Thierry Leblanc, GuangJun Zhang, Marcin W. Wlodarski, Jutte van der Werff ten Bosch
Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2020, 48 (2), pp.770-787. ⟨10.1093/nar/gkz1042⟩
Nucleic acids research, 48(2), 770-787. Oxford University Press
Nucleic Acids Research, 48(2), 770-787. Oxford University Press
Nucleic Acids Research, 48, 770-787
Nucleic Acids Research, Oxford University Press, 2020, 48 (2), pp.770-787. ⟨10.1093/nar/gkz1042⟩
Nucleic Acids Research, 48, 2, pp. 770-787
Contains fulltext : 218593.pdf (Publisher’s version ) (Open Access) Variants in ribosomal protein (RP) genes drive Diamond-Blackfan anemia (DBA), a bone marrow failure syndrome that can also predispose individuals to cancer. Inherited and sporadic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa16e196f68a14dd6e43d49d8991d4fc
https://doi.org/10.1093/nar/gkz1042
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