Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alexandra N Goodman"'
Autor:
Allison J. Li, Alexandra N Goodman, Andrew G. Evans, Mark W. LaMere, Jane L. Liesveld, Sophia R. Balderman, Laura M. Calvi, Michael W. Becker, Mary A. Georger, Benjamin J. Frisch, Corey M. Hoffman
Publikováno v:
Blood. 127:616-625
In vitro evidence suggests that the bone marrow microenvironment (BMME) is altered in myelodysplastic syndromes (MDSs). Here, we study the BMME in MDS in vivo using a transgenic murine model of MDS with hematopoietic expression of the translocation p
Autor:
Alexandra N Goodman, Daniel K. Byun, Mary A. Georger, Rhonda J. Staversky, Michael W. Becker, Laura M. Calvi, Benjamin J. Frisch, Brandon J. Zaffuto
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In murine models of chronic myelogenous leukemia (CML), CCL3 is critical for the maintenance of a leukemia stem cell population
Autor:
Alexandra N. Goodman, Benjamin J. Frisch, Michael W. Becker, Laura M. Calvi, Lila Yang, Rhonda J. Staversky, Mary A. Georger
Publikováno v:
Blood. 128:1482-1482
Background/Rationale: Hematologic malignancies are known to remodel the bone marrow microenvironment, reducing support for normal hematopoiesis while increasing support for the malignant clone. The chemokine CCL3 has been demonstrated to play a role
Autor:
Benjamin J. Frisch, Olga Bromberg, Teresita Bellido, Rhonda J. Staversky, Alexandra N. Goodman, Laura M. Calvi, Xiaolin Tu
Publikováno v:
Blood. 126:1199-1199
The bone marrow microenvironment, including osteolineage cells, regulates hematopoietic stem cell (HSC) fate choices. Intermittent pharmacologic treatment of mice with parathyroid hormone, PTH (1-34), indirectly increases HSCs through their niche, as
Autor:
Alexandra N Goodman, Benjamin J. Frisch, Sophia R. Balderman, Laura M. Calvi, Mark W. LaMere, Michael W. Becker
Publikováno v:
Blood. 124:4359-4359
In vitro data provide evidence of an altered bone marrow microenvironment (BMME) in the myelodysplastic syndromes (MDS). To assess the role of the BMME in MDS in vivo, we used a well-established transgenic murine model with expression of the transloc
Publikováno v:
Blood. 124:772-772
Osteoblasts (OBs) and the bone marrow (BM) vasculature constitute hematopoietic stem and progenitor cell (HSC/HSPC) niches. Immature perivascular osteolineage cells enforce HSC quiescence while signals from mature OBs are capable of bone and vascular
Autor:
Alexandra N Goodman, Michael W. Becker, Benjamin J. Frisch, Sophia R. Balderman, Mark W. LaMere, Laura M. Calvi
Publikováno v:
Blood. 122:2756-2756
Myelodysplastic Syndromes (MDS) are a group of clonal disorders characterized by ineffective hematopoiesis. Recently, data have emerged supporting a role of the bone marrow microenvironment (BMME ) in the initiation of MDS. We and others have previou