Výsledky vyhledávání - "Alexandra Maria Pietersen"

Gene therapy with Apoptin induces regression of xenografted human hepatomas

Autor: Marjolijn M. van der Eb, Mathieu H.M. Noteborn, Cornelis J.H. van de Velde, Frank M. Speetjens, Peter J. K. Kuppen, Alexandra Maria Pietersen, Rob C. Hoeben

Publikováno v: Cancer Gene Therapy. 9:53-61

The chicken anemia virus-derived Apoptin protein shows remarkable specificity; namely, it induces apoptosis in tumor cells, but not in normal diploid cells. We have exploited the Apoptin gene for use in cancer gene therapy. Here we demonstrate that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912c91241d75524dff81cb21028ca44c
https://doi.org/10.1038/sj.cgt.7700397

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Specific tumor-cell killing with adenovirus vectors containing the apoptin gene

Autor: Rob C. Hoeben, Alexandra Maria Pietersen, H J Rademaker, C.J.H. van de Velde, Mathieu H.M. Noteborn, H. van Ormondt, Martijn J. W. E. Rabelink, D Masman, Peter J. K. Kuppen, J. H. Van Dierendonck, A. J. Van Der Eb, M. M. Van Der Eb, D J M van den Wollenberg

Publikováno v: Gene Therapy. 6:882-892

Specificity is an essential prerequisite for cancer gene therapy. Recently we described that apoptin, a protein of 121 amino acids which is derived from the chicken anemia virus, induces programmed cell death or apoptosis in transformed and malignant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ceeda3ee802273c23479273ef82d8f
https://doi.org/10.1038/sj.gt.3300876

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Activation of the tumor-specific death effector apoptin and its kinase by an N-terminal determinant of simian virus 40 large T antigen

Autor: Mathieu H.M. Noteborn, Jennifer L. Rohn, Klaas Kooistra, Alexandra Maria Pietersen, Ying-Hui Zhang

Publikováno v: Journal of virology. 78(18)

Apoptin, a viral death protein derived from chicken anemia virus, displays a number of tumor-specific behaviors. In particular, apoptin is phosphorylated, translocates to the nucleus, and induces apoptosis specifically in tumor or transformed cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca8dea91c8fd5966451ce4ee5c7d195
https://pubmed.ncbi.nlm.nih.gov/15331730

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