Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alexandra Madelaine Tichy"'
Autor:
Fangmin Zhou, Alexandra-Madelaine Tichy, Bibi Nusreen Imambocus, Shreyas Sakharwade, Francisco J. Rodriguez Jimenez, Marco González Martínez, Ishrat Jahan, Margarita Habib, Nina Wilhelmy, Vanessa Burre, Tatjana Lömker, Kathrin Sauter, Charlotte Helfrich-Förster, Jan Pielage, Ilona C. Grunwald Kadow, Harald Janovjak, Peter Soba
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Neuromodulatory signaling via G protein-coupled receptors (GPCRs) plays a pivotal role in regulating neural network function and animal behavior. The recent development of optogenetic tools to induce G protein-mediated signaling provides the
Externí odkaz:
https://doaj.org/article/1c2a5808f1fc4753ab1db2e542681121
Autor:
Alvaro Ingles-Prieto, Nikolas Furthmann, Samuel H Crossman, Alexandra-Madelaine Tichy, Nina Hoyer, Meike Petersen, Vanessa Zheden, Julia Biebl, Eva Reichhart, Attila Gyoergy, Daria E Siekhaus, Peter Soba, Konstanze F Winklhofer, Harald Janovjak
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009479 (2021)
Optogenetics has been harnessed to shed new mechanistic light on current and future therapeutic strategies. This has been to date achieved by the regulation of ion flow and electrical signals in neuronal cells and neural circuits that are known to be
Externí odkaz:
https://doaj.org/article/4dfa5c91f4984c73a153ca31c9329c12
Autor:
Maurizio Morri, Inmaculada Sanchez-Romero, Alexandra-Madelaine Tichy, Stephanie Kainrath, Elliot J. Gerrard, Priscila P. Hirschfeld, Jan Schwarz, Harald Janovjak
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
G-protein coupled receptors (GPCRs) represent the largest receptor family and are prime drug targets, but many orphan GPCRs are poorly characterized. Here authors engineer human orphan GPCRs to be activated by light which allows studying the receptor
Externí odkaz:
https://doaj.org/article/6261fce9394843269dc20223e9a3d059
Autor:
Daniel Čapek, Michael Smutny, Alexandra-Madelaine Tichy, Maurizio Morri, Harald Janovjak, Carl-Philipp Heisenberg
Publikováno v:
eLife, Vol 8 (2019)
Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tiss
Externí odkaz:
https://doaj.org/article/55294d5d287f45b0901b9d4d1dc4b696
Optimized design andin vivoapplication of optogenetically functionalizedDrosophiladopamine receptors
Autor:
Fangmin Zhou, Alexandra-Madelaine Tichy, Bibi Nusreen Imambocus, Francisco J. Rodriguez Jimenez, Marco González Martínez, Ishrat Jahan, Margarita Habib, Nina Wilhelmy, Vanessa Bräuler, Tatjana Lömker, Kathrin Sauter, Charlotte Helfrich-Förster, Jan Pielage, Ilona C. Grunwald Kadow, Harald Janovjak, Peter Soba
Neuromodulatory signalingviaG protein-coupled receptor (GPCRs) plays a pivotal role in regulating neural network function and animal behavior. Recent efforts have led to the development of optogenetic tools to induce G protein-mediated signaling, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb00cd4599bece55e141d1d17afdb00
https://doi.org/10.1101/2023.05.20.541404
https://doi.org/10.1101/2023.05.20.541404
Publikováno v:
Structure (London, England : 1993). 30(8)
G-protein-coupled receptors (GPCRs) are the largest human receptor family and involved in virtually every physiological process. One hallmark of their function is specific coupling to selected signaling pathways. The ability to tune this coupling wou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df85d56141cc0ac2d8e07137133cd1a
https://pubmed.ncbi.nlm.nih.gov/35931057
https://pubmed.ncbi.nlm.nih.gov/35931057
G-protein coupled receptors (GPCRs) are the largest human receptor family and involved in virtually every physiological process. One hallmark of GPCR function is the specific coupling of activated receptors to selected downstream signaling pathways.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6e1df5e2f7c336a765d6e1b5cebc48d
https://doi.org/10.1101/2021.12.13.472518
https://doi.org/10.1101/2021.12.13.472518
Autor:
Elliot Gerrard, Harald Janovjak, Alexandra Madelaine Tichy, Robin M. Hobbs, Julien M. D. Legrand
Publikováno v:
Journal of Molecular Biology. 431:3046-3055
Optogenetics enables the spatio-temporally precise control of cell and animal behavior. Many optogenetic tools are driven by light-controlled protein-protein interactions (PPIs) that are repurposed from natural light-sensitive domains (LSDs). Applyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c351d1c1fb96e3c6a341a607e6ac051a
https://doi.org/10.1016/j.jmb.2019.05.033
https://doi.org/10.1016/j.jmb.2019.05.033
Autor:
Konstanze F. Winklhofer, Samuel H. Crossman, Alexandra Madelaine Tichy, Harald Janovjak, Peter Soba, Eva Reichhart, Nina Hoyer, Nikolas Furthmann, Alvaro Ingles-Prieto, Vanessa Zheden, Julia Biebl, Attila Gyoergy, Daria E Siekhaus, Meike Petersen
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 4, p e1009479 (2021)
PLoS Genetics, Vol 17, Iss 4, p e1009479 (2021)
Optogenetics has been harnessed to shed new mechanistic light on current and future therapeutic strategies. This has been to date achieved by the regulation of ion flow and electrical signals in neuronal cells and neural circuits that are known to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b776cb20d3a38d7b5922e5c7c0eedb82
http://europepmc.org/articles/PMC8049241
http://europepmc.org/articles/PMC8049241
Publikováno v:
Current opinion in structural biology. 57
Light-activated chimeric GPCRs, termed OptoXRs, can elicit cell signalling responses with the high spatial and temporal precision of light. In recent years, an expanding OptoXR toolkit has been applied to, for example, dissect neural circuits in awak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674b579694f7cbc4c4d16c3c47c1adf5
https://pubmed.ncbi.nlm.nih.gov/31207383
https://pubmed.ncbi.nlm.nih.gov/31207383