Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alexandra M. Williams"'
Autor:
Prajan Subedi, Christopher Gasho, Michael Stembridge, Alexandra M. Williams, Alexander Patrician, Philip N. Ainslie, James D. Anholm
Publikováno v:
Experimental Physiology, Vol 108, Iss 1, Pp 111-122 (2023)
Abstract Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being acutely reversible to potentially irreversible. Study subjects were lo
Externí odkaz:
https://doaj.org/article/14c45d9702594740a9d007e981f1c48d
Autor:
Mary P. M. Fossey, Shane J. T. Balthazaar, Jordan W. Squair, Alexandra M. Williams, Malihe-Sadat Poormasjedi-Meibod, Tom E. Nightingale, Erin Erskine, Brian Hayes, Mehdi Ahmadian, Garett S. Jackson, Diana V. Hunter, Katharine D. Currie, Teresa S. M. Tsang, Matthias Walter, Jonathan P. Little, Matt S. Ramer, Andrei V. Krassioukov, Christopher R. West
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
By combining experimental models with prospective clinical studies, the authors show that spinal cord injury causes a rapid reduction in cardiac function that precedes structural changes, and that the loss of descending sympathetic control is the maj
Externí odkaz:
https://doaj.org/article/3046aebaccdc45cdbfc10db7ef4000cf
Autor:
Alexandra M. Williams, Neda Manouchehri, Erin Erskine, Keerit Tauh, Kitty So, Katelyn Shortt, Megan Webster, Shera Fisk, Avril Billingsley, Alex Munro, Seth Tigchelaar, Femke Streijger, Kyoung-Tae Kim, Brian K. Kwon, Christopher R. West
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Clinical neuroprotective strategies for acute spinal cord injury (SCI) have largely overlooked the heart. Here the authors show cardiac contractility is immediately impaired in a porcine model of T2 SCI, and cardio-centric treatment with dobutamine o
Externí odkaz:
https://doaj.org/article/6454cf877f514bc6be1f2dab93e7dfb0
Autor:
Analisa Jia, Lisa Kuramoto, Freda M. Warner, Lisa Liu, Alexandra M. Williams, Annalijn Conklin, Christopher R. West, Jacquelyn J. Cragg
Publikováno v:
The Journal of Spinal Cord Medicine. :1-7
Publikováno v:
The Journal of Physiology. 600:4089-4104
Over the last 100 years, high-altitude researchers have amassed a comprehensive understanding of the global cardiac responses to acute, prolonged and lifelong hypoxia. When lowlanders are exposed to hypoxia, the drop in arterial oxygen content demand
Publikováno v:
Journal of Political Marketing. :1-20
Autor:
Gustavo Vizcardo-Galindo, Tony G. Dawkins, Christopher Gasho, Victoria L Meah, Michael M. Tymko, Andrew R. Steele, Alexandra M. Williams, Craig D. Steinback, Francisco C. Villafuerte, Lydia L. Simpson, Philip N. Ainslie, Mike Stembridge, Jonathan P. Moore, Rómulo Figueroa-Mujíca
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 321:R504-R512
The high-altitude maladaptation syndrome known as chronic mountain sickness (CMS) is characterized by polycythemia and is associated with proteinuria despite unaltered glomerular filtration rate. However, it remains unclear if indigenous highlanders
Publikováno v:
Neurorehabilitation and Neural Repair
Background Spinal cord injury (SCI) leads to a loss of descending motor and sympathetic control below the level of injury (LOI), which ultimately results in chronically altered cardiovascular function and remodeling. While supervised, laboratory-base
Autor:
Mehdi Ahmadian, Alexandra M. Williams, Joseph Mannozzi, Filip Konecny, Ryan L. Hoiland, Liisa Wainman, Erin Erskine, Jennifer Duffy, Neda Manouchehri, Kitty So, Keerit Tauh, Javier A. Sala‐Mercado, Katelyn Shortt, Shera Fisk, Kyoung‐Tae Kim, Femke Streijger, Glen E. Foster, Brian K. Kwon, Donal S. O'Leary, Christopher R. West
Publikováno v:
The Journal of physiology. 600(22)
The assessment of left ventricular (LV) contractility in animal models is useful in various experimental paradigms, yet obtaining such measures is inherently challenging and surgically invasive. In a cross-species study using small and large animals,
Autor:
Alexandra M. Williams, Neda Manouchehri, Keerit Tauh, Kitty So, Megan Webster, Avril Billingsley, Alexandra Munro, Seth Tigchelaar, Femke Streijger, Brian K. Kwon, Christopher R. West, Shera Fisk
Publikováno v:
The FASEB Journal. 36