Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexandra M. Kaufman"'
Autor:
Austen J. Milnerwood, Alexandra M. Kaufman, Marja D. Sepers, Clare M. Gladding, Lily Zhang, Liang Wang, Jing Fan, Ainsley Coquinco, Joy Yi Qiao, Hwan Lee, Yu Tian Wang, Max Cynader, Lynn A. Raymond
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 1, Pp 40-51 (2012)
We recently reported evidence for disturbed synaptic versus extrasynaptic NMDAR transmission in the early pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder caused by CAG repeat expansion in the gene encoding huntingti
Externí odkaz:
https://doaj.org/article/3e3327203f784f0eb5a5da74aaec921e
Autor:
Jing Fan, Clare M. Gladding, Liang Wang, Lily Y.J. Zhang, Alexandra M. Kaufman, Austen J. Milnerwood, Lynn A. Raymond
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 999-1009 (2012)
Huntington disease (HD) is a dominantly inherited neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the protein huntingtin (htt). Previous studies have shown enhanced N-methyl-d-aspartate (NMDA)-induced excitotoxicity in neuron
Externí odkaz:
https://doaj.org/article/24a07aa518fd43889c5d0738a850a1e6
Autor:
Ainsley Coquinco, Max S. Cynader, Marja D. Sepers, Lynn A. Raymond, Liang Wang, Clare M. Gladding, Lily Y. J. Zhang, Jing Fan, Alexandra M. Kaufman, Austen J. Milnerwood, Hwan Lee, Joy Yi Qiao, Yu Tian Wang
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 1, Pp 40-51 (2012)
We recently reported evidence for disturbed synaptic versus extrasynaptic NMDAR transmission in the early pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder caused by CAG repeat expansion in the gene encoding huntingti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d888f24b683961793d14ccbcd9abed1
http://www.sciencedirect.com/science/article/pii/S0969996112001994
http://www.sciencedirect.com/science/article/pii/S0969996112001994
Autor:
Ainsley Coquinco, Marja D. Sepers, Lynn A. Raymond, Alexandra M. Kaufman, Austen J. Milnerwood, Kevin She, Liang Wang, Hwan Lee, Max S. Cynader, Ann Marie Craig
Publikováno v:
The Journal of Neuroscience. 32:3992-4003
The NMDAR plays a unique and vital role in subcellular signaling. Calcium influx initiates signaling cascades important for both synaptic plasticity and survival; however, overactivation of the receptor leads to toxicity and cell death. This dichotom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0e82c4fb71cc277ddf2a58fce8bbed
https://doi.org/10.1523/jneurosci.4129-11.2012
https://doi.org/10.1523/jneurosci.4129-11.2012
Autor:
Lynn A. Raymond, Liang Wang, Alexandra M. Kaufman, Lily Y. J. Zhang, Jing Fan, Clare M. Gladding, Austen J. Milnerwood
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 999-1009 (2012)
Huntington disease (HD) is a dominantly inherited neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the protein huntingtin (htt). Previous studies have shown enhanced N-methyl-d-aspartate (NMDA)-induced excitotoxicity in neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da511b9629beaa3ef1dbd6b761be727
http://www.sciencedirect.com/science/article/pii/S0969996111003949
http://www.sciencedirect.com/science/article/pii/S0969996111003949
Autor:
Mahmoud A. Pouladi, Timothy H. Murphy, Michael R. Hayden, Rona K. Graham, Jamie D. Boyd, Rochelle M. Hines, Oana Cristina Vasuta, Lynn A. Raymond, Clare M. Gladding, Alexandra M. Kaufman, Rebecca W.Y. Ko, Austen J. Milnerwood
Publikováno v:
Neuron. (3):436
SummaryN-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs are poor therapeutic targets, due to their essential physiological ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629cb592db9b06dd966e9c3ce7a2e915