Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Alexandra M. Fajardo"'
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Akademický článek
Antioxidants Abrogate Alpha-Tocopherylquinone-Mediated Down-Regulation of the Androgen Receptor in Androgen-Responsive Prostate Cancer Cells.
Autor: Alexandra M Fajardo, Debra A MacKenzie, Sarah L Olguin, John K Scariano, Ian Rabinowitz, Todd A Thompson
Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151525 (2016)
Tocopherylquinone (TQ), the oxidation product of alpha-tocopherol (AT), is a bioactive molecule with distinct properties from AT. In this study, AT and TQ are investigated for their comparative effects on growth and androgenic activity in prostate ca
Externí odkaz: https://doaj.org/article/1fc0516e6b5d423ea55125d54d003d20
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3
Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention
Autor: Gary A. Piazza, Alexandra M. Fajardo
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 309:G59-G70
Colorectal cancer (CRC) is one of the most common human malignancies and a leading cause of cancer-related deaths in developed countries. Identifying effective preventive strategies aimed at inhibiting the development and progression of CRC is critic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9261e8cd37258a77331dc851bff317f9
https://doi.org/10.1152/ajpgi.00101.2014
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5
The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment
Autor: Gary A. Piazza, Heather N. Tinsley, Alexandra M. Fajardo
Publikováno v: Cancers, Vol 6, Iss 1, Pp 436-458 (2014)
Cancers
For more than four decades, the cyclic nucleotides cyclic AMP (cAMP) and cyclic GMP (cGMP) have been recognized as important signaling molecules within cells. Under normal physiological conditions, cyclic nucleotides regulate a myriad of biological p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6391897efa753c1a3c6a7f63755d01
https://doi.org/10.3390/cancers6010436
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6
Antioxidants Abrogate Alpha-Tocopherylquinone-Mediated Down-Regulation of the Androgen Receptor in Androgen-Responsive Prostate Cancer Cells
Autor: Debra MacKenzie, Alexandra M. Fajardo, John K. Scariano, Todd A. Thompson, Ian Rabinowitz, Sarah L. Olguin
Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151525 (2016)
PLoS ONE
Tocopherylquinone (TQ), the oxidation product of alpha-tocopherol (AT), is a bioactive molecule with distinct properties from AT. In this study, AT and TQ are investigated for their comparative effects on growth and androgenic activity in prostate ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c56a2403505571776fc05c84bb3e44f
http://europepmc.org/articles/PMC4795544?pdf=render
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7
Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives
Autor: Bernard D. Gary, Ashraf H. Abadi, Alexandra M. Fajardo, Amal H. Ali, Gary A. Piazza, Shreen M. El-Nashar, Nermin S. Ahmed, Matthias Negri, Heather N. Tinsley
Publikováno v: European Journal of Medicinal Chemistry. 57:329-343
By studying the co-crystal information of interactions between PDE5 and its inhibitors, forty new tetrahydro-β-carbolines based-analogues were synthesized, and tested for their PDE5 inhibition. Some compounds were as active as tadalafil in inhibitin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026613ed59b0883ec90e3333d82cf4d0
https://doi.org/10.1016/j.ejmech.2012.09.029
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8
The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells
Autor: David L. Vander Jagt, Marco Bisoffi, Alexandra M. Fajardo, Ming Ji, Lorraine M. Deck, Debra MacKenzie, Todd A. Thompson
Publikováno v: The Prostate. 72:612-625
BACKGROUND The androgen receptor (AR) plays a critical role in prostate cancer development and progression. Therefore, the inhibition of AR function is an established therapeutic intervention. Since the expression of the AR is retained and often incr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80458db8798849169843affb158304b3
https://doi.org/10.1002/pros.21464
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9
Quantitative and Spatial Measurements of Telomerase Reverse Transcriptase Expression within Normal and Malignant Human Breast Tissues
Autor: Jeffrey Griffith, Alexandra M. Fajardo, William C. Hines, Nancy E. Joste, Marco Bisoffi
Publikováno v: Molecular Cancer Research. 3:503-509
The enzyme telomerase catalyzes the de novo synthesis of telomere repeats, thereby maintaining telomere length, which is necessary for unlimited cellular proliferation. Telomerase reverse transcriptase (TERT), the catalytic domain of telomerase, is t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60be62fd7fea8c4218ab7348f86fd746
https://doi.org/10.1158/1541-7786.mcr-05-0031
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10
Curcumin Analogs, Oxidative Stress, and Prostate Cancer
Autor: Alexandra M. Fajardo, Marco Bisoffi
The plant natural product curcumin (diferuloylmethane) and its related naturally occurring curcuminoids are remarkable polyphenols with respect to their many biological activities of interest to human oncology, including antioxidant, anti-inflammator
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a22418a7a731bdbd6ce9679e8d3f385
https://doi.org/10.1016/b978-0-12-405205-5.00018-0
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