Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Alexandra M. Blee"'
Autor:
Donglin Ding, Alexandra M. Blee, Jianong Zhang, Yunqian Pan, Nicole A. Becker, L. James Maher, Rafael Jimenez, Liguo Wang, Haojie Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in PCa patient specimens and this co-occurrence
Externí odkaz:
https://doaj.org/article/397f26f685f14e35b502865eb0a5564e
Autor:
Alexandra M. Blee, Haojie Huang
Publikováno v:
Asian Journal of Urology, Vol 3, Iss 1, Pp 1-3 (2016)
Externí odkaz:
https://doaj.org/article/5e4cbf7f331b46928bc2678fa50e3f08
Autor:
Connor J. Beebout, Gabriella L. Robertson, Bradley I. Reinfeld, Alexandra M. Blee, Grace H. Morales, John R. Brannon, Walter J. Chazin, W. Kimryn Rathmell, Jeffrey C. Rathmell, Vivian Gama, Maria Hadjifrangiskou
Publikováno v:
Nat Microbiol
Urinary tract infections are among the most common human bacterial infections and place a significant burden on healthcare systems due to associated morbidity, cost, and antibiotic use. Despite being a facultative anaerobe, uropathogenic Escherichia
Autor:
Jens Meiler, John A. Capra, Walter J. Chazin, Alexandra M Blee, Zachary D. Nagel, Bian Li, T J Pecen
Publikováno v:
Cancer Res
For precision medicine to reach its full potential for treatment of cancer and other diseases, protein variant effect prediction tools are needed to characterize variants of unknown significance (VUS) in a patient's genome with respect to their likel
Autor:
Haojie Huang, Wanhai Xu, Ronald A. DePinho, Y. Alan Wang, Wei-Guo Zhu, S. John Weroha, Jun Zhang, Xiaonan Hou, Joseph Dugdale, Yundong He, Tao Ma, Yuqian Yan, Yunqian Pan, Jian An, Dejie Wang, Alexandra M. Blee, Yinhui Yang
Supplementary Information. File containing Materials and Methods, references for Materials and Methods, a table of PCR primers for genotyping and RT-qPCR studies, and Supplementary Figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb3df1a5414b512cdd34564baa719fe
https://doi.org/10.1158/0008-5472.22415759.v1
https://doi.org/10.1158/0008-5472.22415759.v1
Autor:
Walter J. Chazin, John A. Capra, Zachary D. Nagel, Jens Meiler, Turner Pecen, Bian Li, Alexandra M. Blee
Supplementary Data from An Active Learning Framework Improves Tumor Variant Interpretation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4752b786fe2a6e965427911662377bde
https://doi.org/10.1158/0008-5472.22431782
https://doi.org/10.1158/0008-5472.22431782
Autor:
Haojie Huang, Wanhai Xu, Ronald A. DePinho, Y. Alan Wang, Wei-Guo Zhu, S. John Weroha, Jun Zhang, Xiaonan Hou, Joseph Dugdale, Yundong He, Tao Ma, Yuqian Yan, Yunqian Pan, Jian An, Dejie Wang, Alexandra M. Blee, Yinhui Yang
Supplementary Figure S2. In panel A, immunohistochemistry for ERG in wild-type, Foxo1pc-/-, Pb-ERG and Foxo1pc-/-; Pb-ERG mouse prostates. In panel B, immunohistochemistry for FOXO1 in wild-type, Foxo1pc-/-, Pb-ERG and Foxo1pc-/-; Pb-ERG mouse prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e7a1c4e3ca6e21ebded69c30c65873
https://doi.org/10.1158/0008-5472.22415765.v1
https://doi.org/10.1158/0008-5472.22415765.v1
Autor:
Haojie Huang, Liguo Wang, Wanhai Xu, Yu Chen, Rafael Jimenez, Manish Kohli, Emily Kuehn, Joseph Dugdale, Tao Ma, Yunqian Pan, Yuqian Yan, Zhenqing Ye, Yinhui Yang, Yundong He, Alexandra M. Blee
Purpose: Deletions or mutations in PTEN and TP53 tumor suppressor genes have been linked to lineage plasticity in therapy-resistant prostate cancer. Fusion-driven overexpression of the oncogenic transcription factor ERG is observed in approximately 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b39f0a5f1543b903948db56971ec96
https://doi.org/10.1158/1078-0432.c.6527391.v1
https://doi.org/10.1158/1078-0432.c.6527391.v1
Autor:
Haojie Huang, Wanhai Xu, Ronald A. DePinho, Y. Alan Wang, Wei-Guo Zhu, S. John Weroha, Jun Zhang, Xiaonan Hou, Joseph Dugdale, Yundong He, Tao Ma, Yuqian Yan, Yunqian Pan, Jian An, Dejie Wang, Alexandra M. Blee, Yinhui Yang
E26 transformation-specific transcription factor ERG is aberrantly overexpressed in approximately 50% of all human prostate cancer due to TMPRSS2-ERG gene rearrangements. However, mice with prostate-specific transgenic expression of prostate cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d63d9cc392de7478c56cb14720365a0
https://doi.org/10.1158/0008-5472.c.6509378
https://doi.org/10.1158/0008-5472.c.6509378
Autor:
Haojie Huang, Liguo Wang, Wanhai Xu, Yu Chen, Rafael Jimenez, Manish Kohli, Emily Kuehn, Joseph Dugdale, Tao Ma, Yunqian Pan, Yuqian Yan, Zhenqing Ye, Yinhui Yang, Yundong He, Alexandra M. Blee
Supplementary Figures and Tables. /// Supplementary Figure 1. TP53 mutation status in human prostate cancer. /// Supplementary Figure 2. Genotypic and histological characterization of Pten/Trp53/ERG-altered mouse prostates. /// Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373e5f3e270ad890f059751d1dd7cf97
https://doi.org/10.1158/1078-0432.22469922
https://doi.org/10.1158/1078-0432.22469922