Cancer-specific loss of

Autor: Alexandra M, Amen, Christof, Fellmann, Katarzyna M, Soczek, Shawn M, Ren, Rachel J, Lew, Gavin J, Knott, Jesslyn E, Park, Andrew M, McKinney, Andrew, Mancini, Jennifer A, Doudna, Joseph F, Costello

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Glioblastoma is a highly lethal form of brain cancer with no current treatment options that substantially improve patient outcomes. A key therapeutic challenge is the identification of methods that reduce tumor burden while leaving norma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e48ad2ec993b0fb3f763a1e03d0cf22
https://pubmed.ncbi.nlm.nih.gov/33758097

Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

Autor: Christof Fellmann, Joseph F. Costello, Andrew McKinney, Alexandra M. Amen, Andrew Mancini, Gavin J. Knott, Rachel J. Lew, Shawn M. Ren, Jesslyn E. Park, Katarzyna M. Soczek, Jennifer A. Doudna

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 13

Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase reverse transcriptase (TERT) promoter. TERT promoter mutations create a binding site for a GA binding protein (GABP) transcription factor complex, whose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a472cc8b42a7d114da1be5e2d57934
https://doi.org/10.1101/2020.04.25.061606

CSIG-24. GABP LINKS AMPK SIGNALING TO TERT REGULATION IN A TERT PROMOTER MUTATION DEPENDENT MANNER

Autor: Nicholas Stevers, Andrew McKinney, Joseph F. Costello, Alexandra M. Amen

Publikováno v: Neuro Oncol

Over 90% of human tumors achieve immortality by reactivating telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase. Two mutually exclusive, heterozygous mutations that activate the TERT promoter (TERTp) occur in a wide range of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966b6ab9ff0085e9b684d65fa5f7f286
https://europepmc.org/articles/PMC6846942/

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner

Autor: Josie Hayes, Kyle M. Walsh, Joseph F. Costello, Christof Fellmann, Michael Gapinske, Robert J.A. Bell, Jennifer A. Doudna, Wendy S. Woods, Bruno M. Costa, Chibo Hong, Kien Thiet Nguyen, Pablo Perez-Pinera, Ana Xavier-Magalhães, Alexandra M. Amen, Andrew McKinney, Andrew Mancini, Lindsey E Jones, Jun S. Song

Publikováno v: Cancer cell, vol 34, iss 3
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

TERT promoter mutations reactivate telomerase, allowing for indefinite telomere maintenance and enabling cellular immortalization. These mutations specifically recruit the multimeric ETS factor GABP, which can form two functionally independent transc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f945b41aa8e15375b3f46c87d207658
https://pubmed.ncbi.nlm.nih.gov/30205042

Pilot Controlled Trial of Mindfulness Meditation and Education for Dementia Caregivers

Autor: Helané Wahbeh, James B. Lane, Barry Oken, Daniel P. Zajdel, Mitchell Haas, Alexandra M. Amen, Irina Fonareva

Publikováno v: The Journal of Alternative and Complementary Medicine. 16:1031-1038

The objectives of this study were to evaluate whether a mindfulness meditation intervention may be effective in caregivers of close relatives with dementia and to help refine the protocol for future larger trials.The design was a pilot randomized tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a859380cd3270c135d54b3e03d09377e
https://doi.org/10.1089/acm.2009.0733