Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexandra M Whiteley"'
Autor:
Holly H Black, Jessica L Hanson, Julia E Roberts, Shannon N Leslie, Will Campodonico, Christopher C Ebmeier, G Aaron Holling, Jian Wei Tay, Autumn M Matthews, Elizabeth Ung, Cristina I Lau, Alexandra M Whiteley
Publikováno v:
eLife, Vol 12 (2023)
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS cases are caused by mutation of the proteasome shuttle factor Ubiquilin 2 (UBQLN2), but the mole
Externí odkaz:
https://doaj.org/article/496be42dc5534e3d8968e84acdbd3556
Autor:
Alexandra M Whiteley, Miguel A Prado, Ivan Peng, Alexander R Abbas, Benjamin Haley, Joao A Paulo, Mike Reichelt, Anand Katakam, Meredith Sagolla, Zora Modrusan, Dong Yun Lee, Merone Roose-Girma, Donald S Kirkpatrick, Brent S McKenzie, Steven P Gygi, Daniel Finley, Eric J Brown
Publikováno v:
eLife, Vol 6 (2017)
Ubiquilins (Ubqlns) are a family of ubiquitin receptors that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation. We carried out a proteomic analysis of a B cell lymphoma-derived cell line, BJAB
Externí odkaz:
https://doaj.org/article/42dd1cf6a73646cb83c9e311eb97172a
Autor:
Jessica L Hanson, Holly H Black, Julia E Roberts, Shannon N Leslie, Will Campodonico, Christopher C Ebmeier, G Aaron Holling, Jian Wei Tay, Autumn M Matthews, Elizabeth Ung, Cristina I Lau, Alexandra M Whiteley
Publikováno v:
eLife. 12
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS cases are caused by mutation of the proteasome shuttle factor Ubiquilin 2 (UBQLN2), but the mole
Autor:
Jessica L Hanson, Holly H Black, Julia E Roberts, Shannon N Leslie, Will Campodonico, Christopher C Ebmeier, G Aaron Holling, Jian Wei Tay, Autumn M Matthews, Elizabeth Ung, Cristina I Lau, Alexandra M Whiteley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b772ddc09366e450a0adf9b20bd11fe7
https://doi.org/10.7554/elife.79452.sa2
https://doi.org/10.7554/elife.79452.sa2
Transposable elements can cause catastrophic genomic instability and are tightly regulated by the host through multiple restriction pathways. Domesticated elements are derived from these ancestors and have evolved adaptive roles but may retain pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12cb637a5a71f5e27f299b1e5b16be55
https://doi.org/10.1101/2023.02.03.527044
https://doi.org/10.1101/2023.02.03.527044
Autor:
Holly H. Black, Julia E. Roberts, Shannon N. Leslie, Will Campodonico, Christopher C. Ebmeier, Cristina I. Lau, Alexandra M. Whiteley
SummaryAmyotrophic Lateral Sclerosis (ALS) is a fatal, neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS is caused by mutation of the proteasome shuttle factor Ubiquilin 2 (UBQLN2), but the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::727eb3bd016c2b6cd4f3fe9bf5d810bf
https://doi.org/10.1101/2022.03.25.485837
https://doi.org/10.1101/2022.03.25.485837
Autor:
Ashley Cai, Richard L.M. Faull, Maurice A. Curtis, Daniel Finley, Nicole R. Higgins, Josephine J. Wu, Emma L. Scotter, Cong Fan, Mervyn J. Monteiro, Miguel A. Prado, Christopher Shaw, Jessie E. Greenslade, Alexandra M. Whiteley, Teepu Siddique, Micaela Tatman, Birger Dieriks, Nhat T. T. Le
Publikováno v:
Proceedings of the National Academy of Sciences. 117:15230-15241
Mutations in UBQLN2 cause amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerations. However, the mechanism by which the UBQLN2 mutations cause disease remains unclear. Alterations in proteins involved in autoph
Autor:
Marissa Ashton, Martin Weber, Mark P. Jedrychowski, Thimo Kurz, Daniel Finley, Hai Ngu, Eric J. Brown, Alexandra M. Whiteley, Stefanie A. H. de Poot, Mervyn J. Monteiro, Amy Easton, John Szpyt, Sara L. Dominguez, Steven P. Gygi, Joao A. Paulo, Miguel A. Prado
Publikováno v:
The Journal of Biological Chemistry
Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that act on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4817136e59d4fb8136c5a4764e71e673
https://doi.org/10.1101/2020.02.22.956524
https://doi.org/10.1101/2020.02.22.956524
Autor:
Alexandra M. Whiteley, Benjamin Haley, Dong Yun Lee, Merone Roose-Girma, Steven P. Gygi, Daniel Finley, Anand Kumar Katakam, Meredith Sagolla, Donald S. Kirkpatrick, Eric J. Brown, Zora Modrusan, Brent S. McKenzie, Alexander R. Abbas, Ivan Peng, Mike Reichelt, Joao A. Paulo, Miguel A. Prado
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::330b1488412278eafd49fe53673b581b
https://doi.org/10.7554/elife.26435.026
https://doi.org/10.7554/elife.26435.026
Autor:
Alexander R. Abbas, Donald S. Kirkpatrick, Daniel Finley, Steven P. Gygi, Benjamin Haley, Eric J. Brown, Meredith Sagolla, Joao A. Paulo, Alexandra M. Whiteley, Anand Kumar Katakam, Mike Reichelt, Dong Yun Lee, Merone Roose-Girma, Zora Modrusan, Ivan Peng, Miguel A. Prado, Brent S. McKenzie
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Ubiquilins (Ubqlns) are a family of ubiquitin receptors that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation. We carried out a proteomic analysis of a B cell lymphoma-derived cell line, BJAB