Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Alexandra M Ochsenbein"'
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Akademický článek
Chronic high-fat diet impairs collecting lymphatic vessel function in mice.
Autor: Katrin S Blum, Sinem Karaman, Steven T Proulx, Alexandra M Ochsenbein, Paola Luciani, Jean-Christophe Leroux, Christian Wolfrum, Michael Detmar
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94713 (2014)
Lymphatic vessels play an essential role in intestinal lipid uptake, and impairment of lymphatic vessel function leads to enhanced adipose tissue accumulation in patients with lymphedema and in genetic mouse models of lymphatic dysfunction. However,
Externí odkaz: https://doaj.org/article/7baad07cb68148a7a2f2c73f584562a3
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2
Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling
Autor: Steven T. Proulx, Alexandra M. Ochsenbein, Athanasia Dasargyri, Jyothi Chittazhathu, E. Richard Stanley, Chloé Chong, Michael Detmar, Jean-Christophe Leroux, Sinem Karaman, Rhea Goldmann
Publikováno v: Angiogenesis
Ochsenbein, Alexandra M; Karaman, Sinem; Proulx, Steven T; Goldmann, Rhea; Chittazhathu, Jyothi; Dasargyri, Athanasia; Chong, Chloé; Leroux, Jean-Christophe; Stanley, E Richard; Detmar, Michael (2016). Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling. Angiogenesis, 19(4), pp. 513-524. Springer Netherlands 10.1007/s10456-016-9523-8
Lymphatic vessels play important roles in fluid drainage and in immune responses, as well as in pathological processes including cancer progression and inflammation. While the molecular regulation of the earliest lymphatic vessel differentiation and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbab56949dfbb7b468189b4757251532
http://europepmc.org/articles/PMC5026726
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3
Endothelial cell-derived semaphorin 3A inhibits filopodia formation by blood vascular tip cells
Autor: Steven T. Proulx, Michaela Berchtold, Giorgia Jurisic, Michael Detmar, Esther T. Stoeckli, Sinem Karaman, Alexandra M. Ochsenbein
Publikováno v: Development
Vascular endothelial growth factor (VEGF)-A is a well-known major chemoattractant driver of angiogenesis – the formation of new blood vessels from pre-existing ones. However, the repellent factors that fine-tune this angiogenic process remain poorl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5275f46244af30c5433ea19596cb9331
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5
An Unexpected Role of Semaphorin3A–Neuropilin-1 Signaling in Lymphatic Vessel Maturation and Valve Formation
Autor: Annamari Alitalo, Tatiana V. Petrova, Michael Detmar, Hélène Maby-El Hajjami, Carlos Ochoa Pereira, Sinem Karaman, Shoib S. Siddiqui, Giorgia Jurisic, Alexandra M. Ochsenbein
Publikováno v: Circulation research
Circulation Research, vol. 111, no. 4, pp. 426-436
Rationale: Lymphatic vasculature plays important roles in tissue fluid homeostasis maintenance and in the pathology of human diseases. Yet, the molecular mechanisms that control lymphatic vessel maturation remain largely unknown. Objective: We analyz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f533fd7962f8abe644d16134d89897
https://doi.org/10.1161/circresaha.112.269399
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6
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes
Autor: Esben Pedersen, Klemens Rottner, Astrid L. Basse, Zhipeng Wang, Alexandra M. Ochsenbein, Jolanda van Hengel, Cord Brakebusch, Tine Lefever, Alanna Stanley, Fabio Quondamatteo, Karine Peyrollier, Ben Jackson, Klaus Aktories, Gudula Schmidt, Richard Karlsson, Markus Ladwein
Publikováno v: Molecular Biology of the Cell
RhoA is a small GTPase shown to be crucial for cytokinesis, stress fiber formation, and epithelial cell–cell contacts. Analyzing mice with a keratinocyte-restricted deletion of the RhoA gene, we find that RhoA is not required for skin development a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e339244a359b854959472d64018601c
https://doi.org/10.1091/mbc.e09-10-0859
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7
Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet
Autor: Michael Detmar, Maija Hollmén, Harri Nurmi, Bettina Morf, Alexandra M. Ochsenbein, Christian Wolfrum, Sinem Karaman, Marius R. Robciuc, Kari Alitalo, Dorina Buschle, Annamari Alitalo, H. Furkan Alkan
Publikováno v: Molecular Metabolism
Molecular Metabolism, 4 (2)
Objective: Elevated serum levels of the lymphangiogenic factors VEGF-C and -D have been observed in obese individuals but their relevance for the metabolic syndrome has remained unknown. Methods: K14-VEGFR-3-Ig (sR3) mice that constitutively express
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5174c02b571bdd64d67b9e970638240e
http://hdl.handle.net/10138/175977
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8
The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation
Autor: Alexandra M. Ochsenbein, Michael Detmar, Sinem Karaman, Giorgia Jurisic
Publikováno v: Advances in Anatomy, Embryology and Cell Biology
Developmental Aspects of the Lymphatic Vascular System ISBN: 9783709116456
During development, the lymphatic and the blood vascular system form highly branched networks that show extensive architectural similarities with the peripheral nervous system. Increasing evidence suggests that the vascular and the nervous systems sh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae0c8cab2a703efe836948ffbb1382e
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9
The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation
Autor: Alexandra M, Ochsenbein, Sinem, Karaman, Giorgia, Jurisic, Michael, Detmar
Publikováno v: Advances in anatomy, embryology, and cell biology. 214
During development, the lymphatic and the blood vascular system form highly branched networks that show extensive architectural similarities with the peripheral nervous system. Increasing evidence suggests that the vascular and the nervous systems sh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::97ab40b8448a65f86405d2207e2f6a2a
https://pubmed.ncbi.nlm.nih.gov/24276892
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