Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Alexandra M Binder"'
Autor:
Kimberly C Paul, Alexandra M Binder, Steve Horvath, Cynthia Kusters, Qi Yan, Irish Del Rosario, Yu Yu, Jeff Bronstein, Beate Ritz
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Aging and inflammation are important components of Parkinson’s disease (PD) pathogenesis and both are associated with changes in hematopoiesis and blood cell composition. DNA methylation (DNAm) presents a mechanism to investigat
Externí odkaz:
https://doaj.org/article/64f238afeebf48a38f75f5c1e5ecd9ea
Autor:
Alexandra M Binder, Leah T Stiemsma, Kristen Keller, Sanne D van Otterdijk, Verónica Mericq, Ana Pereira, José L Santos, John Shepherd, Karin B Michels
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Abstract Background Estrogen receptor-α (ER-α) is a transcriptional regulator, which mediates estrogen-dependent breast development, as well as breast tumorigenesis. The influence of epigenetic regulation of ER-α on adolescent breast composition h
Externí odkaz:
https://doaj.org/article/a2f803dfab9e450487fc62b7d64de388
Autor:
Sanne D van Otterdijk, Alexandra M Binder, Katarzyna Szarc Vel Szic, Julia Schwald, Karin B Michels
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180955 (2017)
The prevalence of type 2 diabetes (T2D) and the metabolic syndrome (MetS) is increasing and several studies suggested an involvement of DNA methylation in the development of these metabolic diseases. This study was designed to investigate if differen
Externí odkaz:
https://doaj.org/article/300b571e821945d29f6c2c7fd2608c84
Autor:
Karin B. Michels, Alexandra M. Binder
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTFolate is an essential mediator in one-carbon metabolism, which provides methyl groups for DNA synthesis and methylation. The availability of active methyl groups can be influenced by the uptake of folic acid. We conducted a randomized interv
Externí odkaz:
https://doaj.org/article/423caddaed6445b5890254cd05da6d37
Autor:
En Cheng, Bette J. Caan, Peggy M. Cawthon, William J. Evans, Marc K. Hellerstein, Mahalakshmi Shankaran, Kristin L. Campbell, Alexandra M. Binder, Barbara Sternfeld, Jeffrey A. Meyerhardt, Kathryn H. Schmitz, Elizabeth M. Cespedes Feliciano
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 6, Pp 2768-2778 (2023)
Abstract Background Low skeletal muscle mass (myopenia) is common in cancer populations and is associated with functional decline and mortality, but prior oncology studies did not assess total body skeletal muscle mass. Instead, they measured surroga
Externí odkaz:
https://doaj.org/article/2d60ccf5f7264903bfc6650d7af16625
Autor:
Diana Ponce, Fernando Rodríguez, José P. Miranda, Alexandra M. Binder, José L. Santos, Karin B. Michels, Gordon B. Cutler, Ana Pereira, Germán Iñiguez, Verónica Mericq
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyperinsulinemia, dyslipidemia, and polycystic ovary syndrome.
Externí odkaz:
https://doaj.org/article/7428a6c1936f4beaa926de779c9b4405
Autor:
Claire E. Kim, Alexandra M. Binder, Camila Corvalan, Ana Pereira, John Shepherd, Antonia M. Calafat, Julianne C. Botelho, John M. Hampton, Amy Trentham-Dietz, Karin B. Michels
Publikováno v:
Environment International, Vol 181, Iss , Pp 108241- (2023)
Introduction: High mammographic density is among the strongest and most established predictors for breast cancer risk. Puberty, the period during which breasts undergo exponential mammary growth, is considered one of the critical stages of breast dev
Externí odkaz:
https://doaj.org/article/3939ba11d43a46ecbac428829a203c73
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Tumor subtype and menopausal status are strong predictors of breast cancer (BC) prognosis. We aimed to find and validate subtype- or menopausal-status-specific changes in tumor DNA methylation (DNAm) associated with all-cause mortality or BC progress
Externí odkaz:
https://doaj.org/article/07b62eb1ac094364a96b7a99049fd53d
Autor:
Victor Yuan, E. Magda Price, Giulia Del Gobbo, Sara Mostafavi, Brian Cox, Alexandra M. Binder, Karin B. Michels, Carmen Marsit, Wendy P. Robinson
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Background The influence of genetics on variation in DNA methylation (DNAme) is well documented. Yet confounding from population stratification is often unaccounted for in DNAme association studies. Existing approaches to address confounding
Externí odkaz:
https://doaj.org/article/02c4ae74a7e34e4682b3456b469c8329
Autor:
Alexandra M. Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B. Michels
Publikováno v:
Epigenetics, Vol 13, Iss 1, Pp 85-94 (2018)
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal
Externí odkaz:
https://doaj.org/article/5ed7d26eaf9045098bb667506555021b