Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alexandra Lenard"'
Autor:
Jessica Haladyna, Kathrin M. Bernt, Simone S. Riedel, Clara Libbrecht, Fatemeh Alikarami, Alexandra Lenard, Gerard M. McGeehan, Hongbo Xie, Patricia Ernst, Molly C. Kingsley
Publikováno v:
Leukemia
Translocations of Meningioma-1 (MN1) occur in a subset of acute myeloid leukemias (AML) and result in high expression of MN1, either as a full-length protein, or as a fusion protein that includes most of the N-terminus of MN1. High levels of MN1 corr
Autor:
Simone S. Riedel, Alexandra Lenard, Nan Zhu, Taylor Pastuer, Molly C. Kingsley, Tobias Neff, Zuo-Fei Yuan, Tyler Shank, Clara Libbrecht, Hongbo Michael Xie, Kathrin M. Bernt
Publikováno v:
Exp Hematol
Inhibition of the H3K79 histone methyltransferase DOT1L has exhibited encouraging preclinical and early clinical activity in KMT2A (MLL)-rearranged leukemia, supporting the development of combinatorial therapies. Here, we investigated two novel combi
Autor:
Fatemeh Alikarami, Robert B. Faryabi, Jun Qi, Eugene Khandros, Bin Lu, Alexandra Lenard, Hua Huang, Kathrin M. Bernt, Yeqiao Zhou, Krista A. Budinich, Molly C. Kingsley, Will Bailis, Aoi Wakabayashi, Qingzhou Chen, Junwei Shi, Martin Carroll, Zhendong Cao, Zhen Zhang, Gerd A. Blobel, Diqiu Ren, Shelley L. Berger, Yu-Han Huang
Publikováno v:
Molecular cell. 81(17)
Summary The transformed state in acute leukemia requires gene regulatory programs involving transcription factors and chromatin modulators. Here, we uncover an IRF8-MEF2D transcriptional circuit as an acute myeloid leukemia (AML)-biased dependency. W
Autor:
Bin Lu, Alexandra Lenard, Martin Carroll, Bianca Pingul, Gerd A. Blobel, Jun Qi, Junwei Shi, Kathrin M. Bernt, Zhendong Cao, Zhen Zhang, Shelley L. Berger, Hua Huang, Molly C. Kingsley, Yeqiao Zhou, Yu-Han Huang, Robert B. Faryabi, Krista A. Budinich, Diqiu Ren
Publikováno v:
Cancer Research. 81:LB205-LB205
The transformed state in acute leukemia requires gene regulatory programs involving transcription factors (TFs) and chromatin modulators. Here, we uncover an IRF8-MEF2D TF regulatory circuit as an acute myeloid leukemia (AML)-specific dependency. We
Autor:
Nan Zhu, Hongbo Michael Xie, Zuo-Fei Yuan, Simone S. Riedel, Alexandra Lenard, Tobias Neff, Kathrin M. Bernt
Inhibition of the histone methyl-transferase DOT1L (KMT4) has shown encouraging activity in preclinical models of KMT2A (MLL)-rearranged leukemia. The DOT1L inhibitor pinometostat (EPZ5676) was well tolerated in early phase clinical trials and showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e51e7644b434a40376e3bb33058292c