Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Alexandra Lebedeva"'
1
Akademický článek
Evaluation of blood MSI burden dynamics to trace immune checkpoint inhibitor therapy efficacy through the course of treatment
Autor: Egor Veselovsky, Alexandra Lebedeva, Olesya Kuznetsova, Daria Kravchuk, Ekaterina Belova, Anastasia Taraskina, Tatiana Grigoreva, Alexandra Kavun, Victoria Yudina, Laima Belyaeva, Vladislav Nikulin, Vladislav Mileyko, Alexey Tryakin, Mikhail Fedyanin, Maxim Ivanov
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Analysis of serial liquid biopsy (LB) samples has been found to be a promising approach for the monitoring of tumor dynamics in the course of therapy for patients with colorectal cancer (CRC). Currently, somatic mutations are used for tracin
Externí odkaz: https://doaj.org/article/9cca0cfa19eb4dbb9444304fd76b5d69
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2
Akademický článek
Evidence blocks for effective presentation of genomic findings at molecular tumor boards: Single institution experience
Autor: Alexandra Lebedeva, Olesya Kuznetsova, Maxim Ivanov, Alexandra Kavun, Egor Veselovsky, Ekaterina Belova, Vladislav Mileyko, Valentina Yakushina, Polina Shilo, Alexey Tryakin, Alexey Rumyantsev, Fedor Moiseenko, Mikhail Fedyanin, Dmitry Nosov
Publikováno v: Heliyon, Vol 10, Iss 9, Pp e30303- (2024)
Genomic profiling, or molecular profiling of the tumor, is becoming a key component of therapeutic decision making in clinical oncology, and is typically carried out via next generation sequencing. However, the interpretation of the results and evalu
Externí odkaz: https://doaj.org/article/7718f5a3b252465981cb2c0b26fb09e4
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3
Akademický článek
Case Report: Progressive disease of BRCA2-mutant colon adenocarcinoma following talazoparib therapy
Autor: Elizaveta Polyanskaya, Alexandra Lebedeva, Olesya Kuznetsova, Ekaterina Belova, Alexandra Kavun, Maxim Ivanov, Mikhail Fedyanin, Alexey Tryakin, Vladislav Mileyko, Dmitry Nosov
Publikováno v: Frontiers in Oncology, Vol 13 (2023)
Colorectal cancer (CRC) is currently one of the most common tumor types diagnosed worldwide. In the early stages, the disease responds well to surgical and chemotherapeutic treatment, but in the later stages when therapeutic options are exhausted, co
Externí odkaz: https://doaj.org/article/1d2c8448ae5e4200969af1ec70e054f3
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4
Akademický článek
Incidental germline findings during molecular profiling of tumor tissues for precision oncology: molecular survey and methodological obstacles
Autor: Alexandra Lebedeva, Yulia Shaykhutdinova, Daria Seriak, Ekaterina Ignatova, Ekaterina Rozhavskaya, Divyasphoorthi Vardhan, Sofia Manicka, Margarita Sharova, Tatiana Grigoreva, Ancha Baranova, Vladislav Mileyko, Maxim Ivanov
Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background A fraction of patients referred for complex molecular profiling of biopsied tumors may harbor germline variants in genes associated with the development of hereditary cancer syndromes (HCS). Neither the bioinformatic analysis nor
Externí odkaz: https://doaj.org/article/9b680c109ac444c3a3dd89445ab64863
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6
Microsatellite Instability: A Review of Molecular Epidemiology and Implications for Immune Checkpoint Inhibitor Therapy
Autor: Alexandra Kavun, Egor Veselovsky, Alexandra Lebedeva, Ekaterina Belova, Olesya Kuznetsova, Valentina Yakushina, Tatiana Grigoreva, Vladislav Mileyko, Mikhail Fedyanin, Maxim Ivanov
Publikováno v: Cancers. 15:2288
Microsatellite instability (MSI) is one of the most important molecular characteristics of a tumor, which occurs among various tumor types. In this review article, we examine the molecular characteristics of MSI tumors, both sporadic and Lynch-associ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1742c66453b08d77564c67298163ade4
https://doi.org/10.3390/cancers15082288
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7
Incidental germline findings during molecular profiling of tumor tissues for precision oncology: molecular survey and methodological obstacles
Autor: Alexandra Lebedeva, Yulia Shaykhutdinova, Daria Seriak, Ekaterina Ignatova, Ekaterina Rozhavskaya, Divyasphoorthi Vardhan, Sofia Manicka, Margarita Sharova, Tatiana Grigoreva, Ancha Baranova, Vladislav Mileyko, Maxim Ivanov
Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Background A fraction of patients referred for complex molecular profiling of biopsied tumors may harbor germline variants in genes associated with the development of hereditary cancer syndromes (HCS). Neither the bioinformatic analysis nor the repor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2596f68beb67a381a9c30ee9c5edb3
https://pubmed.ncbi.nlm.nih.gov/35033101
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9
Importance of critical evaluation of genomic findings reported following comprehensive tumor molecular profiling (CTMP) for discussion within molecular tumor boards (MTB)
Autor: Alexandra Lebedeva, Maxim Ivanov, Olesya Kuznetsova, Margarita Sharova, Ekaterina Ignatova, Alexey Tryakin, Vladislav Mileyko, Mikhail Fedyanin, Dmitry Nosov
Publikováno v: Journal of Clinical Oncology. 40:e18623-e18623
e18623 Background: As precision oncology evolves, a growing number of physicians refer cancer patients for CTMP. Oftentimes, CTMP cannot be performed at local centers and patients turn to third-party facilities or commercial solutions. CTMP findings
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57d873cc27299c7b6f84589d4b44e3b2
https://doi.org/10.1200/jco.2022.40.16_suppl.e18623
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