Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexandra L. Nguyen"'
Publikováno v:
Molecular Biology of the Cell
Similar to other core biological processes, the vast majority of cell division components are essential for viability across human cell lines. However, genome-wide screens have identified a number of proteins that exhibit cell line-specific essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aee78c7923bebddcfb0ccccb5cbdef1
https://doi.org/10.1091/mbc.e20-11-0751
https://doi.org/10.1091/mbc.e20-11-0751
Autor:
Alexandra L. Nguyen, Karen Schindler
Publikováno v:
Trends in Genetics. 33:349-363
The aurora kinases (AURKs) comprise an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis. While most mitotic cells express two AURK isoforms (AURKA and AURKB), mammalian germ cells also express a third, AURKC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48009cbf306ae649fb4b097017f57fa2
https://doi.org/10.1016/j.tig.2017.03.005
https://doi.org/10.1016/j.tig.2017.03.005
Autor:
Marcos Malumbres, Alexandra L. Nguyen, Berta N. Vazquez, Karen Schindler, David Drutovic, Warif El Yakoubi, Amanda S. Gentilello, Petr Solc
SUMMARY: Errors in chromosome segregation during female meiosis I occur frequently, and aneuploid embryos account for 1/3 of all miscarriages in humans [1]. Unlike mitotic cells that require two Aurora kinase (AURK) homologs to help prevent aneuploid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ae8eb961cb0d518e046c7e9fd12491
https://europepmc.org/articles/PMC6234855/
https://europepmc.org/articles/PMC6234855/
Publikováno v:
Chromosoma. 126(3)
Several aspects of meiosis are impacted by the absence of centrosomes in oocytes. Here we review four aspects of meiosis I that are significantly affected by the absence of centrosomes in oocyte spindles. One, microtubules tend to assemble around the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cebd39cc2f9665bd5b598f278c522e
https://pubmed.ncbi.nlm.nih.gov/27837282
https://pubmed.ncbi.nlm.nih.gov/27837282
Autor:
Alexandra L. Nguyen, Karen Schindler, David Drutovic, Ahmed Z. Balboula, Petr Solc, Amanda S. Gentilello, Suzanne M. Quartuccio
Publikováno v:
Journal of Cell Science.
Meiotic oocytes lack classic centrosomes and therefore, bipolar spindle assembly depends on clustering of acentriolar microtubule-organizing centers (MTOCs) into two poles. However, the molecular mechanism regulating MTOCs assembly into two poles is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3ca29273ecf473647df5e7d4fe1179
https://doi.org/10.1242/jcs.189340
https://doi.org/10.1242/jcs.189340
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Gene modification within the murine genome has become a powerful and invaluable tool to investigate development. One example of the utility of such technology is providing a method by which researchers can follow cells throughout development via the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0241a3cacbb370031cdfc4b3767bf0f2
https://doi.org/10.1002/mrd.22864
https://doi.org/10.1002/mrd.22864
Akademický článek
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Autor:
Deanne Taylor, Diego Marin, Nathan R. Treff, Anastasia Fedick, Jinchuan Xing, Karen Schindler, Yujue Wang, Alexandra L. Nguyen, Anbo Zhou
Publikováno v:
Fertility and Sterility. 106:e76-e77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::385414ade3a1b3cbcbf4a73fb2b9869c
https://doi.org/10.1016/j.fertnstert.2016.07.225
https://doi.org/10.1016/j.fertnstert.2016.07.225
Autor:
Osvaldo Américo Bogado Pascottini, Beatriz Fernandez-Fuertes, Gauthier Schang, Alexandra L. Nguyen, Samantha C. Lean
Publikováno v:
Molecular Reproduction and Development. 84:667-667
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4537cd537e52e05087573443318dbedd
https://doi.org/10.1002/mrd.22855
https://doi.org/10.1002/mrd.22855
Autor:
Jason Jay Merkin, Ronald E. Ellis, Maxim V. Dorovkov, Alexandra L. Nguyen, Hsueh-Ping Chu, James S. Novak, Robert G. Nagele, Yuriy Shymkiv, Bart P. Braeckman, David E. Harrison, Zhixian Hu, Peter M. Clifford, Alexey G. Ryazanov, Yi Liao
SummaryThe control of germline quality is critical to reproductive success and survival of a species; however, the mechanisms underlying this process remain unknown. Here, we demonstrate that elongation factor 2 kinase (eEF2K), an evolutionarily cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5e7bccd96247f2e93e46d1f47987b0
https://europepmc.org/articles/PMC4712648/
https://europepmc.org/articles/PMC4712648/