Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexandra L. Mattei"'
Autor:
Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, Julie Donaghey, Kendell Clement, Hongcang Gu, Arman W. Mohammad, Elena K. Stamenova, Davide Cacchiarelli, Sven Klages, Bernd Timmermann, Tobias Cantz, Hans R. Schöler, Andreas Gnirke, Michael J. Ziller, Alexander Meissner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Catalytically inactive Cas9 fused to a methyltransferase has emerged as a promising epigenome modifying tool. Here the authors generate a methylation depleted but maintenance competent mouse ES cell line and find ubiquitous off-target activity.
Externí odkaz:
https://doaj.org/article/facfcb998fb94a91ab5dd5199cd3a1b4
Publikováno v:
Trends in Genetics
In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance was not intuitive for several decades. After this initial lag, the ubiquitous presence of this methylated base emerged across all domains of life and reveale
Autor:
Sara Hetzel, Alexandra L. Mattei, Helene Kretzmer, Chunxu Qu, Xiang Chen, Yiping Fan, Gang Wu, Kathryn G. Roberts, Selina Luger, Mark Litzow, Jacob Rowe, Elisabeth Paietta, Wendy Stock, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Charles G. Mullighan, Alexander Meissner
Publikováno v:
Nature Cancer
DNA methylation is tightly regulated during development and is stably maintained in healthy cells. In contrast, cancer cells are commonly characterized by a global loss of DNA methylation co-occurring with CpG island hypermethylation. In acute lympho
Autor:
Alessa R. Ringel, Quentin Szabo, Andrea M. Chiariello, Konrad Chudzik, Robert Schöpflin, Patricia Rothe, Alexandra L. Mattei, Tobias Zehnder, Dermot Harnett, Verena Laupert, Simona Bianco, Sara Hetzel, Juliane Glaser, Mai H.Q. Phan, Magdalena Schindler, Daniel M. Ibrahim, Christina Paliou, Andrea Esposito, Cesar A. Prada-Medina, Stefan A. Haas, Peter Giere, Martin Vingron, Lars Wittler, Alexander Meissner, Mario Nicodemi, Giacomo Cavalli, Frédéric Bantignies, Stefan Mundlos, Michael I. Robson
Publikováno v:
Cell
Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and functions during evolution. Here, we investigated how a placental mammal-specific gene, Zfp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e9142d1b2b33cf90aa22817b71f0ee
https://hdl.handle.net/11588/902575
https://hdl.handle.net/11588/902575
Autor:
Quentin Szabo, M. Phan, Giacomo Cavalli, Cesar Augusto Prada-Medina, Christina Paliou, Sara Hetzel, Michael I. Robson, K. Chudzik, Andrea M. Chiariello, Stephan Haas, Tobias Zehnder, Daniel M. Ibrahim, Alexander Meissner, Andrea Esposito, R. Schoepflin, P. Giere, P. Rothe, Simona Bianco, Martin Vingron, V. Laupert, Dermot Harnett, Stefan Mundlos, Frédéric Bantignies, Alessa R. Ringel, Lars Wittler, Alexandra L. Mattei, Mario Nicodemi, Magdalena Schindler
Publikováno v:
bioRxiv
SUMMARYCohesin loop extrusion facilitates precise gene expression by continuously driving promoters to sample all enhancers located within the same topologically-associated domain (TAD). However, many TADs contain multiple genes with divergent expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4599ee2b7ed6fc682687ac1ce79055ae
https://doi.org/10.1101/2021.10.08.463672
https://doi.org/10.1101/2021.10.08.463672
Autor:
Alexander Meissner, Seher Ipek Gassaloglu, Rui Chen, Maximilian Stötzel, René Buschow, Aydan Bulut-Karslioglu, Jesse V. Veenvliet, Alexandra L. Mattei, Sara Hetzel, Ronald Maitschke-Rajasekharan, Iiris Virta, Burak Koksal, Derya Atilla, Marina Typou, Natalia López-Anguita, David Meierhofer, Ivan Bedzhov
The cellular microenvironment together with intrinsic regulators shapes stem cell identity and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and appear to benefit from hypoxic culture in vitro. Yet, components of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4267c62cdf303f791a2d60344d95445a
https://doi.org/10.1101/2021.07.21.452906
https://doi.org/10.1101/2021.07.21.452906
Autor:
David Meierhofer, Raha Weigert, Nina Bailly, Claudia Giesecke-Thiel, Judith Gottfreund, Chuck Haggerty, Alexander Meissner, Jörn Walter, Christina Galonska, Abhishek Sampath Kumar, Thorsten Mielke, Franz-Josef Müller, Björn Brändl, Pascal Giehr, Helene Kretzmer, Bernd Timmermann, Lars Wittler, Ferdinand von Meyenn, René Buschow, Christina Riemenschneider, Alexandra L. Mattei, Melissa B. Pappalardi, Pay Giesselmann, Michael T. McCabe
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology, 28 (7)
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology, 28 (7)
DNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the de novo Dnmts, 3a and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e4b7af8005f3f8745559b53e7b4eaa
Autor:
Kendell Clement, Hans R. Schöler, Alexandra L. Mattei, Elena K. Stamenova, Julie Donaghey, Andreas Gnirke, Hongcang Gu, Alexander Meissner, Bernd Timmermann, Christina Galonska, Arman W. Mohammad, Jocelyn Charlton, Tobias Cantz, Sven Klages, Michael J. Ziller, Davide Cacchiarelli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications
In normal mammalian development cytosine methylation is essential and is directed to specific regions of the genome. Despite notable advances through mapping its genome-wide distribution, studying the direct contribution of DNA methylation to gene an
Autor:
Nina Bailly, Andreas Gnirke, Alexander Meissner, Elena K. Stamenova, Eric J. Martin, Franz-Josef Müller, Jocelyn Charlton, Björn Brändl, Zachary D. Smith, Alexandra L. Mattei, Evangelos Kiskinis, Jing Liao, Pay Giesselmann, Eunmi J. Jung
Publikováno v:
Nature genetics
Nature Genetics
Nature Genetics
Mammalian cells stably maintain high levels of DNA methylation despite expressing both positive (DNMT3A/B) and negative (TET1–3) regulators. Here, we used wildtype and TET triple knockout human embryonic stem cells (ESCs), generated DNMT3-null as w
Publikováno v:
Proceedings of the National Academy of Sciences. 112:8475-8480
Physiological changes in females during and after mating are triggered by seminal fluid components in conjunction with female-derived molecules. In insects, these changes include increased egg production, storage of sperm, and changes in muscle contr