Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexandra L. Lane"'
Autor:
George W. J. Fleet, David R. Brown, Helen Ardron, Thomas Martin Krulle, Benjamin L. Davis, Neil A. Hindle, Daniel G. Marquess, Daniel D. Long, Alexandra L. Lane, Colin Smith, David J. Watkin
Displacement of α-triflates of 2,3,4-all cis-substituted γ-lactones by sodium azide in DMF gives kinetically an azide with inversion of configuration at the C-2 of the lactone; under the reaction conditions, the initially formed azide epimerises to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7bc39733cd0fa1b2dcadbfade593f7
https://doi.org/10.1039/cc9960001271
https://doi.org/10.1039/cc9960001271
Autor:
Juan C. Estévez, Alexandra L. Lane, Sarah Crook, Gurdyal S. Besra, David J. Watkin, Martin D. Smith, Patrick J. Brennan, Robert J. Nash, George W. J. Fleet
An α-azidocarboxylate of a tetrahydrofuran derived from l -rhamnose may be used as a divergent intermediate for a wide range of mimics of l -rhamnofuranose, which contain a constituent α-amino acid moiety at the anomeric position, and include anome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50a42fbef732912b5f0d29b3727ce66
https://doi.org/10.1016/0957-4166(96)00013-4
https://doi.org/10.1016/0957-4166(96)00013-4
Autor:
Bryan Winchester, Sarah Crook, Yves Blériot, Alexandra L. Lane, George W. J. Fleet, Joanne Charlwood, Christian F. Masaguer, David J. Watkin
Syntheses of the two epimeric 6C-methylglucoses from D-glucuronolactone rely on a non-stereoselective reduction of an intermediate lactol. A highly stereoselective reduction of a silylated lactol, which is accompanied by a silyl migration, gives easy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96671b74701aa3993235f370fdec8e8
https://ora.ox.ac.uk/objects/uuid:8a1649b9-51bc-4841-aa25-6a144b9fd75b
https://ora.ox.ac.uk/objects/uuid:8a1649b9-51bc-4841-aa25-6a144b9fd75b
Autor:
Sean M. Lynn, Kathryn H. Smelt, Keith Biggadike, Alexandra L. Lane, George W. J. Fleet, David J. Watkin, Yves Blériot
Publikováno v:
Tetrahedron Letters. 40:3255-3258
Photobromination of a rigid bicyclic α-L-fucose analogue, affords a single crystalline monobromide, the structure of which is confirmed by X-ray crystallography. Displacement of this bromide with azide proceeds with inversion to a single crystalline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48e4acd984df2379c1a881384d91756
https://doi.org/10.1016/s0040-4039(99)00377-9
https://doi.org/10.1016/s0040-4039(99)00377-9
Autor:
Clifford R. Veighey, David J. Watkin, Kathryn H. Smelt, Yves Blériot, Willy Stalmans, Matthias Müller, Joan A. Cadefau, George W. J. Fleet, Keith Biggadike, Alexandra L. Lane
Publikováno v:
Tetrahedron: Asymmetry. 7:2761-2772
The synthesis of the epimeric 6- C -phenylglucoses is reported; these are the first compounds with one of the prochiral methylene hydrogens on C-6 of a hexose being replaced by an aryl group. Both isomers inhibit glucokinase and provide further indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f3da0171508925c157e9cb83f587c56
https://doi.org/10.1016/0957-4166(96)00356-4
https://doi.org/10.1016/0957-4166(96)00356-4
Autor:
Keith Biggadike, Kathryn H. Smelt, Matthias Mueller, C. R. Veighey, Alexandra L. Lane, David J. Watkin, Yves Blériot, George W. J. Fleet, J. Cadefau, W. Stalmans
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494d93743f6815b9b7834c8effb3d452
https://doi.org/10.1002/chin.199703258
https://doi.org/10.1002/chin.199703258
Autor:
Alexandra L. Lane, Martin D. Smith, Patrick J. Brennan, George W. J. Fleet, Sarah Crook, David J. Watkin, Gurdyal S. Besra, Juan C. Estévez, Robert J. Nash
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb495008c53daeaa3a848ad54fbd7ae6
https://doi.org/10.1002/chin.199627226
https://doi.org/10.1002/chin.199627226
Autor:
Louise N. Johnson, W. Stalmans, Kathryn H. Smelt, Mathieu Bollen, Nikos G. Oikonomakos, David J. Watkin, Keith Biggadike, Sarah Crook, Joan A. Cadefau, Alexandra L. Lane, Yves Blériot, George W. J. Fleet
Publikováno v:
ChemInform. 28
Short efficient syntheses of epimeric C6- C -methyl glucoses are described. One C-6 epimer activates glycogen synthase while the other epimer inactivates the enzyme; C6 R -C-methyl glucose 3 is the first example of a specific inhibitor of glucose-6-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3047ab41f179a2cc6cf7710a9339887e
https://doi.org/10.1002/chin.199701275
https://doi.org/10.1002/chin.199701275
Autor:
Yves Blériot, George W. J. Fleet, Sarah Crook, Christian F. Masaguer, J. Charlwood, Bryan Winchester, Alexandra L. Lane, David J. Watkin
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ba353bd078a76337ae1151f55a295b9
https://doi.org/10.1002/chin.199807229
https://doi.org/10.1002/chin.199807229
Autor:
George W. J. Fleet, Daniel G. Marquess, Signe M. Frederiksen, Alexandra L. Lane, Daniel D. Long, David J. Watkin, David A. Winkler
Publikováno v:
TETRAHEDRON LETTERS. 39(33)
Bicyclic 2 and monocyclic 6 2-amino-1,4-lactones provide divergent intermediates for subsequent incorporation of polyhydroxylated prolines into combinatorial amide libraries. The X-ray crystal structure of an azidolactone, combined with molecular mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b560e7962d6f542f4d18d357e6f795b
http://ora.ox.ac.uk/objects/uuid:078f0384-7135-41ef-a76a-0ed75d54128a
http://ora.ox.ac.uk/objects/uuid:078f0384-7135-41ef-a76a-0ed75d54128a