Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexandra L. Crampton"'
Autor:
Arja Ray, Mackenzie K. Callaway, Nelson J. Rodríguez-Merced, Alexandra L. Crampton, Marjorie Carlson, Kenneth B. Emme, Ethan A. Ensminger, Alexander A. Kinne, Jonathan H. Schrope, Haley R. Rasmussen, Hong Jiang, David G. DeNardo, David K. Wood, Paolo P. Provenzano
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Pancreatic ductal adenocarcinoma (PDA) is an extremely metastatic and lethal disease. Here, in both murine and human PDA, we demonstrate that extracellular matrix architecture regulates cell extrusion and subsequent invasion from intact ductal struct
Externí odkaz:
https://doaj.org/article/bcdf632fadae49d698cc8059eaed9db9
Autor:
Alex T Larsson, Himanshi Bhatia, Ana Calizo, Kai Pollard, Xiaochun Zhang, Eric Conniff, Justin F Tibbitts, Elizabeth Rono, Katherine Cummins, Sara H Osum, Kyle B Williams, Alexandra L Crampton, Tyler Jubenville, Daniel Schefer, Kuangying Yang, Yang Lyu, James C Pino, Jessica Bade, John M Gross, Alla Lisok, Carina A Dehner, John S A Chrisinger, Kevin He, Sara J C Gosline, Christine A Pratilas, David A Largaespada, David K Wood, Angela C Hirbe
Publikováno v:
Neuro-Oncology.
Background Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that often develop in patients with neurofibromatosis type 1 (NF1). To address the critical need for novel therapeutics in MPNST, we aimed to establish an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6039c6fd8a56c7fa88ceae08ddd8c926
https://doi.org/10.1093/neuonc/noad097
https://doi.org/10.1093/neuonc/noad097
Publikováno v:
Gene Expr
Human liver models that are three-dimensional (3D) in architecture are indispensable for compound metabolism/toxicity screening, to model liver diseases for drug discovery, and for cell-based therapies; however, further development of such models is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade4fb3e8b4208a2743ef09adfe1369b
https://doi.org/10.3727/105221620x15868728381608
https://doi.org/10.3727/105221620x15868728381608
Human liver models that are 3-dimensional (3D) in architecture are proving to be indispensable for diverse applications, including compound metabolism and toxicity screening during preclinical drug development, to model human liver diseases for the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70442940c6ea2af34e9ecd0f41d5fb11
Publikováno v:
TECHNOLOGY. :80-87
The objective of this study was to create a method for studying cell–matrix interactions in a physiologically relevant 3D protein-based tissue construct that could be scaled up to perform large-scale screens, study cell–matrix interactions on a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a251c0659555521cd2e23607dffa8de
https://doi.org/10.1142/s2339547816400094
https://doi.org/10.1142/s2339547816400094
Publikováno v:
Tissue engineering. Part C, Methods. 25(1)
Changes to the cellular microenvironment are an integral characteristic of numerous pathologies, including cancer, fibrosis, and autoimmune disease. Current in vitro methodologies available to study three-dimensional tissue remodeling are ill-suited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc3d980b00e3b3f32a1230dff725553
https://pubmed.ncbi.nlm.nih.gov/31166828
https://pubmed.ncbi.nlm.nih.gov/31166828
Publikováno v:
Integrative biology : quantitative biosciences from nano to macro. 10(9)
A critical role of vascular endothelium is as a semi-permeable barrier, dynamically regulating the flux of solutes between blood and the surrounding tissue. Existing platforms that quantify endothelial function in vitro are either significantly throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ecc781d79a28295ef407ac224dd9ce
https://pubmed.ncbi.nlm.nih.gov/30140833
https://pubmed.ncbi.nlm.nih.gov/30140833
Publikováno v:
Tissue Engineering Part C: Methods. 25:446-446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f81920a3efe49b0c2169590e202118
https://doi.org/10.1089/ten.tec.2018.0290.correx
https://doi.org/10.1089/ten.tec.2018.0290.correx
Autor:
Kathleen Powers, Alexandra L. Crampton, Shon Vanhoozer, Nathan Basisty, Matthew S. O'Connor, Natalie Friedricks, Amutha Boominathan, Birgit Schilling, Xiaobin Wang, Martin D. Brand
Publikováno v:
Nucleic Acids Research
We explore the possibility of re-engineering mitochondrial genes and expressing them from the nucleus as an approach to rescue defects arising from mitochondrial DNA mutations. We have used a patient cybrid cell line with a single point mutation in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c918fab16cb7f58235c59603ecc808af
https://doi.org/10.1093/nar/gkw756
https://doi.org/10.1093/nar/gkw756