Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alexandra L. Bey"'
Publikováno v:
Neurobiology of Disease, Vol 110, Iss , Pp 12-19 (2018)
Epilepsy is prevalent and often medically intractable in Angelman syndrome (AS). AS mouse model (Ube3am−/p+) shows reduced excitatory neurotransmission but lower seizure threshold. The neural mechanism linking the synaptic dysfunction to the seizur
Externí odkaz:
https://doaj.org/article/0082dc84acac421492c82f07cf46503c
Autor:
Xiaoming Wang, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, Sunil Kumar, Stephen D. Mague, Samuel W. Hulbert, Nisha Dutta, Volodya Hayrapetyan, Chunxiu Yu, Erin Gaidis, Shengli Zhao, Jin-Dong Ding, Qiong Xu, Leeyup Chung, Ramona M. Rodriguiz, Fan Wang, Richard J. Weinberg, William C. Wetsel, Kafui Dzirasa, Henry Yin, Yong-hui Jiang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
SHANK3 mutations have been linked to autism spectrum disorders, although the underlying mechanisms remain unclear. Here, the authors generate a complete knockout Shank3 mouse model, identifying ASD-like behaviours associated with impaired mGluR5-Home
Externí odkaz:
https://doaj.org/article/31226ec3e0a84099b658a1cc0d12be11
Autor:
Andrew Yuan, Maura Sabatos-DeVito, Alexandra L Bey, Samantha Major, Kimberly LH Carpenter, Lauren Franz, Jill Howard, Saritha Vermeer, Ryan Simmons, Jesse Troy, Geraldine Dawson
Publikováno v:
Autism. :136236132311695
Autistic children’s play provides insights into social, communication, and other skills; however, methods for measuring these observations can be labor-intensive and rely on subjective judgment. This study explored whether children’s movement and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c41c5d50274a2a8ff26d12a01e31d84
https://doi.org/10.1177/13623613231169546
https://doi.org/10.1177/13623613231169546
Autor:
Stephen D. Mague, Austin Talbot, Cameron Blount, Kathryn K. Walder-Christensen, Lara J. Duffney, Elise Adamson, Alexandra L. Bey, Nkemdilim Ndubuizu, Gwenaëlle E. Thomas, Dalton N. Hughes, Yael Grossman, Rainbo Hultman, Saurabh Sinha, Alexandra M. Fink, Neil M. Gallagher, Rachel L. Fisher, Yong-Hui Jiang, David E. Carlson, Kafui Dzirasa
Publikováno v:
Neuron. 110(10)
The architecture whereby activity across many brain regions integrates to encode individual appetitive social behavior remains unknown. Here we measure electrical activity from eight brain regions as mice engage in a social preference assay. We then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315cd3f0fabfe118f424fae4cd741efa
https://pubmed.ncbi.nlm.nih.gov/35588713
https://pubmed.ncbi.nlm.nih.gov/35588713
Autor:
Elise Adamson, Saurabh R. Sinha, Rachel L. Fisher, Cameron Blount, Dalton Hughes, Alexandra L. Bey, Stephen D. Mague, Austin Talbot, Yong-hui Jiang, David E. Carlson, Kafui Dzirasa, Gwenaёlle Thomas, Alexandra M. Fink, Neil M. Gallagher, Nkemdilim Ndubuizu, Kathryn K. Walder-Christensen, Lara J. Duffney
Many cortical and subcortical regions contribute to complex social behavior; nevertheless, the network level architecture whereby the brain integrates this information to encode appetitive socioemotional behavior remains unknown. Here we measure elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87bda9fe2bbbfa5c881280d61c898135
https://doi.org/10.1101/2020.07.01.181347
https://doi.org/10.1101/2020.07.01.181347
Background: The developmental origins of Autism Spectrum Disorder (ASD) remain largely unknown. To begin to answer this question, a few studies have implemented conditional gene expression technology to induce or rescue ASD-causing mutations at diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad9a63588bdc03ea6b29dc299dbaf9b4
https://doi.org/10.21203/rs.3.rs-31397/v1
https://doi.org/10.21203/rs.3.rs-31397/v1
Autor:
Teresa M. Kohlenberg, William Gallentine, Jennifer Frankovich, Mark P. Gorman, Yong-hui Jiang, Keith Van Haren, Alexandra L. Bey
Publikováno v:
Pediatrics. 145
Phenotypic and biological characterization of rare monogenic disorders represents 1 of the most important avenues toward understanding the mechanisms of human disease. Among patients with SH3 and multiple ankyrin repeat domains 3 (SHANK3) mutations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90cb4c40820f5d4a09f698c313938f28
https://doi.org/10.1542/peds.2019-1490
https://doi.org/10.1542/peds.2019-1490
Publikováno v:
Neurobiology of Disease, Vol 110, Iss, Pp 12-19 (2018)
Epilepsy is prevalent and often medically intractable in Angelman syndrome (AS). AS mouse model (Ube3am−/p+) shows reduced excitatory neurotransmission but lower seizure threshold. The neural mechanism linking the synaptic dysfunction to the seizur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fb2a6d9b0e927cb5091994823f3e6a
http://www.sciencedirect.com/science/article/pii/S0969996117302425
http://www.sciencedirect.com/science/article/pii/S0969996117302425
Autor:
Kathryn K. Walder-Christensen, Kafui Dzirasa, David E. Carlson, Elise Adamson, Stephen D. Mague, Noah Lanier, Alexandra L. Bey, Jack Goffinet
Publikováno v:
Journal of the American Academy of Child & Adolescent Psychiatry. 60:S167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ce9a1e4bfc5025e92cc106f6a9b17d
https://doi.org/10.1016/j.jaac.2021.09.101
https://doi.org/10.1016/j.jaac.2021.09.101
Publikováno v:
PLoS Genetics, Vol 3, Iss 8, p e132 (2007)
MUS81 is conserved among plants, animals, and fungi and is known to be involved in mitotic DNA damage repair and meiotic recombination. Here we present a functional characterization of the Arabidopsis thaliana homolog AtMUS81, which has a role in bot
Externí odkaz:
https://doaj.org/article/aa347bef663545208dd07fb02cde897d