Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Alexandra L Joyner"'
Autor:
Ryan T Willett, N Sumru Bayin, Andrew S Lee, Anjana Krishnamurthy, Alexandre Wojcinski, Zhimin Lao, Daniel Stephen, Alberto Rosello-Diez, Katherine L Dauber-Decker, Grant D Orvis, Zhuhao Wu, Marc Tessier-Lavigne, Alexandra L Joyner
Publikováno v:
eLife, Vol 8 (2019)
For neural systems to function effectively, the numbers of each cell type must be proportioned properly during development. We found that conditional knockout of the mouse homeobox genes En1 and En2 in the excitatory cerebellar nuclei neurons (eCN) l
Externí odkaz:
https://doaj.org/article/dac5953036a24d41a919545b03161f3f
Autor:
Andrew K Lawton, Tyler Engstrom, Daniel Rohrbach, Masaaki Omura, Daniel H Turnbull, Jonathan Mamou, Teng Zhang, J M Schwarz, Alexandra L Joyner
Publikováno v:
eLife, Vol 8 (2019)
Models based in differential expansion of elastic material, axonal constraints, directed growth, or multi-phasic combinations have been proposed to explain brain folding. However, the cellular and physical processes present during folding have not be
Externí odkaz:
https://doaj.org/article/559ea937f3904648b54e0398dd315aa1
Autor:
N Sumru Bayin, Alexandre Wojcinski, Aurelien Mourton, Hiromitsu Saito, Noboru Suzuki, Alexandra L Joyner
Publikováno v:
eLife, Vol 7 (2018)
Outside of the neurogenic niches of the brain, postmitotic neurons have not been found to undergo efficient regeneration. We demonstrate that mouse Purkinje cells (PCs), which are born at midgestation and are crucial for development and function of c
Externí odkaz:
https://doaj.org/article/0d3997780886410a8199e611bd72599a
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2005086 (2018)
Catch-up growth after insults to growing organs is paramount to achieving robust body proportions. In fly larvae, injury to individual tissues is followed by local and systemic compensatory mechanisms that allow the damaged tissue to regain normal pr
Externí odkaz:
https://doaj.org/article/495083437bb048468a8d2e2553cc2e7b
Publikováno v:
eLife, Vol 6 (2017)
Regulation of organ growth is a poorly understood process. In the long bones, the growth plates (GPs) drive elongation by generating a scaffold progressively replaced by bone. Although studies have focused on intrinsic GP regulation, classic and rece
Externí odkaz:
https://doaj.org/article/4cf39bee6ecf4b6d9bf537b941c6dd56
Autor:
Reeti Mayur Sanghrajka, Richard Koche, Hector Medrano, Salsabiel El Nagar, Daniel N. Stephen, Zhimin Lao, N. Sumru Bayin, Kai Ge, Alexandra L. Joyner
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107831- (2023)
Summary: The major cause of treatment failure and mortality among medulloblastoma patients is metastasis intracranially or along the spinal cord. The molecular mechanisms driving tumor metastasis in Sonic hedgehog-driven medulloblastoma (SHH-MB) pati
Externí odkaz:
https://doaj.org/article/0ff602ca0cc44d9cb6da3c5af8918d2e
Autor:
Harikrishna Rallapalli, N. Sumru Bayin, Hannah Goldman, Dragan Maric, Brian J. Nieman, Alan P. Koretsky, Alexandra L. Joyner, Daniel H. Turnbull
Publikováno v:
NeuroImage, Vol 276, Iss , Pp 120198- (2023)
Magnetic Resonance Imaging (MRI) resolution continues to improve, making it important to understand the cellular basis for different MRI contrast mechanisms. Manganese-enhanced MRI (MEMRI) produces layer-specific contrast throughout the brain enablin
Externí odkaz:
https://doaj.org/article/f5291e0394464c1ea3b1b8d620ae031f
Autor:
Alexandra L. Joyner, N. Sumru Bayin
Publikováno v:
Development (Cambridge, England). 149(18)
ABSRACT The cerebellum has a simple cytoarchitecture consisting of a folded cortex with three cell layers that surrounds a nuclear structure housing the output neurons. The excitatory neurons are generated from a unique progenitor zone, the rhombic l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f083b6b7578e003afa0960ae37c8d44e
https://pubmed.ncbi.nlm.nih.gov/36172987
https://pubmed.ncbi.nlm.nih.gov/36172987
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 1, Pp 39-52 (2017)
It is widely appreciated that reactive stroma or carcinoma-associated fibroblasts can influence epithelial tumor progression. In prostate cancer (PCa), the second most common male malignancy worldwide, the amount of reactive stroma is variable and ha
Externí odkaz:
https://doaj.org/article/e6f6f902ee1e4c45b0e290eb57ba765c
Publikováno v:
Contemporary Clinical Neuroscience ISBN: 9783031231032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9084387c2e813a79d473db4dcbb4190
https://doi.org/10.1007/978-3-031-23104-9_3
https://doi.org/10.1007/978-3-031-23104-9_3
