Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alexandra L Ghaben"'
Autor:
Chelsea Hepler, Bo Shan, Qianbin Zhang, Gervaise H Henry, Mengle Shao, Lavanya Vishvanath, Alexandra L Ghaben, Angela B Mobley, Douglas Strand, Gary C Hon, Rana K Gupta
Publikováno v:
eLife, Vol 7 (2018)
White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional heterogeneity of adipose stromal cells has remained unresolved. We combined single-cell RNA-
Externí odkaz:
https://doaj.org/article/57648c7063664e9e832063f3c90b7ec1
Autor:
Chelsea Hepler, Mengle Shao, Jonathan Y Xia, Alexandra L Ghaben, Mackenzie J Pearson, Lavanya Vishvanath, Ankit X Sharma, Thomas S Morley, William L Holland, Rana K Gupta
Publikováno v:
eLife, Vol 6 (2017)
Visceral adiposity confers significant risk for developing metabolic disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (WAT) appears protective. Unlike subcutaneous WAT, visceral WAT is resistant to adopting a pro
Externí odkaz:
https://doaj.org/article/a1deae3e19564b3796959deac5eab293
Autor:
Thomas S. Morley, Clair Crewe, Yu An, Ruth Gordillo, Joshua A. Johnson, Alexandra L. Ghaben, Ricardo J. Samms, Nolwenn Joffin, Toshiharu Onodera, Philipp E. Scherer, Christine M. Kusminski, William L. Holland, Andrew C. Adams
Publikováno v:
Diabetes
Obesity-associated type 2 diabetes mellitus (T2DM) entails insulin resistance and loss of β-cell mass. Adipose tissue mitochondrial dysfunction is emerging as a key component in the etiology of T2DM. Identifying approaches to preserve mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87058a97126de601f66ace31fe0c3063
https://doi.org/10.2337/db19-0327
https://doi.org/10.2337/db19-0327
Publikováno v:
Nature Reviews Molecular Cell Biology. 20:242-258
Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion. The expansion of adipose depots can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18610b855b379795ea17f2ab142def21
https://doi.org/10.1038/s41580-018-0093-z
https://doi.org/10.1038/s41580-018-0093-z
Autor:
Clair Crewe, Alexandra L. Ghaben, Christy M. Gliniak, Philipp E. Scherer, Yucel Akgul, Jan-Bernd Funcke, Nolwenn Joffin, Dmitri Samovski, Yu An, Shiuhwei Chen, Christine M. Kusminski, Hesham A. Sadek, Pamela Fischer-Posovszky, Ruth Gordillo, Shujuan Li, Samuel Klein
Publikováno v:
Cell Metab
Adipocytes undergo intense energetic stress in obesity resulting in loss of mitochondrial mass and function. We have found that adipocytes respond to mitochondrial stress by rapidly and robustly releasing small extracellular vesicles (sEVs). These sE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b936f56ea7c634a8389ca2fc898e18
https://pubmed.ncbi.nlm.nih.gov/35211656
https://pubmed.ncbi.nlm.nih.gov/35211656
Autor:
Yingfeng Deng, Zhuzhen Zhang, Shangang Zhao, Qingzhang Zhu, May-Yun Wang, Laurent Gautron, Yi Zhu, Zhenzhen Zi, Philipp E. Scherer, Shiuhwei Chen, Jan-Bernd Funcke, Prithvi Raj, Clair Crewe, Christine M. Kusminski, Charlotte E. Lee, Luke J. Engelking, Alexandra L. Ghaben, Ruth Gordillo, Na Li, Leon G. Straub, Yu An
Publikováno v:
Cell Metab
Iron overload is positively associated with diabetes risk. However, the role of iron in adipose tissue remains incompletely understood. Here, we report that transferrin-receptor-1-mediated iron uptake is differentially required for distinct subtypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbe35d161f6feea5fb483ccba5ca43b
https://pubmed.ncbi.nlm.nih.gov/34348093
https://pubmed.ncbi.nlm.nih.gov/34348093
Autor:
Yunguan Wang, Cigall Kadoch, Philipp E. Scherer, Tao Wang, Yuemeng Jia, Jordan E. Otto, Jiyoung Park, Clayton K. Collings, Shunli Shen, Zixi Wang, Alexandra L. Ghaben, Cemre Celen, Jen Chieh Chuang, Xuxu Sun, Ibrahim Nassour, Xin Luo, Lin Li, Hao Zhu, Sam C. Wang
SummaryThe dynamic regulation of β-cell abundance is poorly understood. Since chromatin remodeling plays critical roles in liver regeneration, these mechanisms could be generally important for regeneration in other tissues. Here we show that the ARI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0be870315d8b3fe1b0f4a6a079708f
https://doi.org/10.1101/2020.02.10.942615
https://doi.org/10.1101/2020.02.10.942615
Autor:
Ruth Gordillo, Kai Sun, William L. Holland, Jonathan Y. Xia, Christine M. Kusminski, Rana K. Gupta, Chelsea Hepler, Yu An, Thomas S. Morley, Philipp E. Scherer, Alexandra L. Ghaben, Andrew C. Adams
Publikováno v:
Diabetologia. 61:932-941
AIM/HYPOTHESIS: Adiponectin (APN), a circulating hormone secreted by mature adipocytes, has been extensively studied because it has beneficial metabolic effects. While many studies have focused on the congenital loss of APN and its effects on systemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20ad32b807dadfd884afaba90dabeeb
https://doi.org/10.1007/s00125-017-4516-8
https://doi.org/10.1007/s00125-017-4516-8
Autor:
Chao Xing, Shangang Zhao, Fang Zhang, Mengle Shao, Ruth Gordillo, Olga Zagnitko, Hua V. Lin, Yang Li, Ping Xu, Philipp E. Scherer, Yi Zhu, Bei B. Zhang, Yingfeng Deng, Alexandra L. Ghaben, Huachuan Cao, Rana K. Gupta, David Scott
Publikováno v:
Diabetes
Transcripts of key enzymes in the Leloir pathway of galactose metabolism in mouse livers are significantly increased after chronic high-fat/high-sucrose feeding. UDP-galactose-4-epimerase (GALE) is the last enzyme in this pathway that converts UDP-ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8495ac1dfb96d729ef214458a20cf2
http://europepmc.org/articles/PMC5652600
http://europepmc.org/articles/PMC5652600
Autor:
Chelsea Hepler, Yingfeng Deng, Ashwani Kumar, Laurent Gautron, Qingzhang Zhu, May-Yun Wang, Chao Xing, Clair Crewe, Yu An, Qiong A. Wang, Philipp E. Scherer, Lavanya Vishvanath, Toshiharu Onodera, Christine M. Kusminski, Na Li, Zhenzhen Zi, Alexandra L. Ghaben, Mengle Shao, Shangang Zhao, Yi Zhu, Rana K. Gupta, Ilja L. Kruglikov, Nolwenn Joffin, Zhuzhen Zhang, Ruth Gordillo
Dermal adipose tissue (also known as dermal white adipose tissue and herein referred to as dWAT) has been the focus of much discussion in recent years. However, dWAT remains poorly characterized. The fate of the mature dermal adipocytes and the origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83be4617e3e229a4e05fde28422d475f
https://europepmc.org/articles/PMC6877341/
https://europepmc.org/articles/PMC6877341/