Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alexandra L Condurat"'
Autor:
Prasidda Khadka, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M. Carvalho, Juliann Shih, Shu Zhang, Noah F. Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G. Miller, Alexandra L. Condurat, Elizabeth M. Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E. Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E. Guerra Garcia, Claire E. Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S. Persky, David E. Root, Angel M. Carcaboso, Benjamin L. Ebert, Christine Fuller, Ozgun Babur, Mark W. Kieran, Chris Jones, Hasmik Keshishian, Keith L. Ligon, Steven A. Carr, Timothy N. Phoenix, Pratiti Bandopadhayay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract The role of PPM1D mutations in de novo gliomagenesis has not been systematically explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas and find that truncating mutations in PPM1D that increase the stability of
Externí odkaz:
https://doaj.org/article/05d88dcae9c94b0ba00bbf84c4d8c770
Autor:
Zachary J. Reitman, Brenton R. Paolella, Guillaume Bergthold, Kristine Pelton, Sarah Becker, Robert Jones, Claire E. Sinai, Hayley Malkin, Ying Huang, Leslie Grimmet, Zachary T. Herbert, Yu Sun, Jessica L. Weatherbee, John A. Alberta, John F. Daley, Orit Rozenblatt-Rosen, Alexandra L. Condurat, Kenin Qian, Prasidda Khadka, Rosalind A. Segal, Daphne Haas-Kogan, Mariella G. Filbin, Mario L. Suva, Aviv Regev, Charles D. Stiles, Mark W. Kieran, Liliana Goumnerova, Keith L. Ligon, Alex K. Shalek, Pratiti Bandopadhayay, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.
Externí odkaz:
https://doaj.org/article/751f4dad2db84b0f893ba0445a18b1bd
Autor:
Timothy N. Phoenix, Pratiti Bandopadhayay, David T.W. Jones, Henry Long, Claudia L. Kleinman, Volker Hovestadt, Keith L. Ligon, Stefan M. Pfister, Olaf Witt, Nada Jabado, François Aguet, Gad Getz, James M. McFarland, Jinghui Zhang, Suzanne J. Baker, Stefan Bielack, Michaela Nathrath, Christof M. Kramm, Gnana Prakash Balasubramanian, Natalie Jager, Uta Dirksen, David S. Ziegler, Maria Tsoli, J'Ya Hunter, Dana Novikov, Rushil Kumbhani, Jeromy J. Digiacomo, Madison S. Chacon, Elizabeth M. Gonzalez, Sophie D. Lu, Kevin N. Zhou, Sarah E. Dixon-Clarke, Alexandra L. Condurat, Xiaolong Chen, Audrey Baguette, Cecilia Sousa, Jayne Vogelzang, Kristine Pelton, Alexander Crane, Frank P.B. Dubois, Sudeepa Syamala, Ningxuan Zhou, Xin Wei, Phonepasong Arounleut, David W. Wu, Smruti Patel, Dayle K. Wang, Paloma Cejas, Jessica W. Tsai
Forkhead box R2 (FOXR2) is a forkhead transcription factor located on the X chromosome whose expression is normally restricted to the testis. In this study, we performed a pan-cancer analysis of FOXR2 activation across more than 10,000 adult and pedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::741da86f253c6e42c0401531e9509b90
https://doi.org/10.1158/0008-5472.c.6514136.v1
https://doi.org/10.1158/0008-5472.c.6514136.v1
Autor:
Timothy N. Phoenix, Pratiti Bandopadhayay, David T.W. Jones, Henry Long, Claudia L. Kleinman, Volker Hovestadt, Keith L. Ligon, Stefan M. Pfister, Olaf Witt, Nada Jabado, François Aguet, Gad Getz, James M. McFarland, Jinghui Zhang, Suzanne J. Baker, Stefan Bielack, Michaela Nathrath, Christof M. Kramm, Gnana Prakash Balasubramanian, Natalie Jager, Uta Dirksen, David S. Ziegler, Maria Tsoli, J'Ya Hunter, Dana Novikov, Rushil Kumbhani, Jeromy J. Digiacomo, Madison S. Chacon, Elizabeth M. Gonzalez, Sophie D. Lu, Kevin N. Zhou, Sarah E. Dixon-Clarke, Alexandra L. Condurat, Xiaolong Chen, Audrey Baguette, Cecilia Sousa, Jayne Vogelzang, Kristine Pelton, Alexander Crane, Frank P.B. Dubois, Sudeepa Syamala, Ningxuan Zhou, Xin Wei, Phonepasong Arounleut, David W. Wu, Smruti Patel, Dayle K. Wang, Paloma Cejas, Jessica W. Tsai
Supplementary Figure from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c77d20498973705d006fee266ee01a
https://doi.org/10.1158/0008-5472.22432439.v1
https://doi.org/10.1158/0008-5472.22432439.v1
Autor:
Timothy N. Phoenix, Pratiti Bandopadhayay, David T.W. Jones, Henry Long, Claudia L. Kleinman, Volker Hovestadt, Keith L. Ligon, Stefan M. Pfister, Olaf Witt, Nada Jabado, François Aguet, Gad Getz, James M. McFarland, Jinghui Zhang, Suzanne J. Baker, Stefan Bielack, Michaela Nathrath, Christof M. Kramm, Gnana Prakash Balasubramanian, Natalie Jager, Uta Dirksen, David S. Ziegler, Maria Tsoli, J'Ya Hunter, Dana Novikov, Rushil Kumbhani, Jeromy J. Digiacomo, Madison S. Chacon, Elizabeth M. Gonzalez, Sophie D. Lu, Kevin N. Zhou, Sarah E. Dixon-Clarke, Alexandra L. Condurat, Xiaolong Chen, Audrey Baguette, Cecilia Sousa, Jayne Vogelzang, Kristine Pelton, Alexander Crane, Frank P.B. Dubois, Sudeepa Syamala, Ningxuan Zhou, Xin Wei, Phonepasong Arounleut, David W. Wu, Smruti Patel, Dayle K. Wang, Paloma Cejas, Jessica W. Tsai
Supplementary Table from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010b86034115df2220900de572ba0818
https://doi.org/10.1158/0008-5472.22432385
https://doi.org/10.1158/0008-5472.22432385
Autor:
Jessica W. Tsai, Paloma Cejas, Marissa Coppola, Dayle K. Wang, Smruti Patel, David W. Wu, Phonepasong Arounleut, Xin Wei, Ningxuan Zhou, Sudeepa Syamala, Frank P. Dubois, Kristine Pelton, Jayne Vogelzang, Cecilia Sousa, Audrey Baguette, Xiaolong Chen, Alexandra L. Condurat, Sarah E. Dixon-Clarke, Annarah Charles, Kevin N. Zhou, Sophie D. Lu, Elizabeth M. Gonzalez, Madison S. Chacon, Jeromy J. Digiacomo, Rushil Kumbhani, Dana Novikov, Maria Tsoli, David S. Ziegler, Uta Dirksen, Natalie Jager, Gnana Prakash Balasubramanian, Christof M. Kramm, Michaela Nathrath, Stefan Bielack, Suzanne J. Baker, Jinghui Zhang, James M. McFarland, Gad Getz, Francois Aguet, Nada Jabado, Olaf Witt, Stefan M. Pfister, Keith L. Ligon, Volker Hovestadt, Claudia Kleinman, Henry Long, David T. Jones, Pratiti Bandopadhayay, Timothy N. Phoenix
Publikováno v:
Cancer Research. 83:3562-3562
Background: Diffuse midline gliomas (DMGs) are a universally fatal brain tumor of childhood. While histone mutations are a critical tumor initiating event, they are insufficient to drive gliomagenesis. Histone mutations co-occur with somatic alterati
FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
Autor:
Jessica W. Tsai, Paloma Cejas, Dayle K. Wang, Smruti Patel, David W. Wu, Phonepasong Arounleut, Xin Wei, Ningxuan Zhou, Sudeepa Syamala, Frank P.B. Dubois, Alexander Crane, Kristine Pelton, Jayne Vogelzang, Cecilia Sousa, Audrey Baguette, Xiaolong Chen, Alexandra L. Condurat, Sarah E. Dixon-Clarke, Kevin N. Zhou, Sophie D. Lu, Elizabeth M. Gonzalez, Madison S. Chacon, Jeromy J. Digiacomo, Rushil Kumbhani, Dana Novikov, J'Ya Hunter, Maria Tsoli, David S. Ziegler, Uta Dirksen, Natalie Jager, Gnana Prakash Balasubramanian, Christof M. Kramm, Michaela Nathrath, Stefan Bielack, Suzanne J. Baker, Jinghui Zhang, James M. McFarland, Gad Getz, François Aguet, Nada Jabado, Olaf Witt, Stefan M. Pfister, Keith L. Ligon, Volker Hovestadt, Claudia L. Kleinman, Henry Long, David T.W. Jones, Pratiti Bandopadhayay, Timothy N. Phoenix
Publikováno v:
Cancer Res
Forkhead box R2 (FOXR2) is a forkhead transcription factor located on the X chromosome whose expression is normally restricted to the testis. In this study, we performed a pan-cancer analysis of FOXR2 activation across more than 10,000 adult and pedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b04fde1eafeb27aba2cd478be2c63a8
https://europepmc.org/articles/PMC9437574/
https://europepmc.org/articles/PMC9437574/
Autor:
Jessica W. Tsai, Paloma Cejas, Dayle K. Wang, Smruti Patel, David W. Wu, Phonepasong Arounleut, Xin Wei, Ningxuan Zhou, Sudeepa Syamala, Frank P. Dubois, Kristine Pelton, Jayne Vogelzang, Cecilia Sousa, Audrey Baguette, Xiaolong Chen, Alexandra L. Condurat, Sarah E. Dixon-Clarke, Kevin N. Zhou, Sophie D. Lu, Elizabeth M. Gonzalez, Madison S. Chacon, Jeromy J. Digiacomo, Rushil Kumbhani, Dana Novikov, J'Ya Hunter, Maria Tsoli, David S. Ziegler, Uta Dirksen, Natalie Jager, Gnana Prakash Balasubramanian, Christof M. Kramm, Michaela Nathrath, Stefan Bielack, Suzanne J. Baker, Jinghui Zhang, James M. McFarland, Gad Getz, Francois Aguet, Nada Jabado, Olaf Witt, Stefan M. Pfister, Keith L. Ligon, Claudia Kleinman, Henry Long, David T. Jones, Pratiti Bandopadhayay, Timothy N. Phoenix
Publikováno v:
Cancer Research. 82:5730-5730
Background: Understanding how aberrant transcription factors (TFs) hijack normal development to induce oncogenesis is a critical question in oncology. Forkhead box (FOX) proteins are a superfamily of transcriptional regulators characterized by a fork
Autor:
Jessica W Tsai, Paloma Cejas, Dayle K Wang, Smruti Patel, David W Wu, Phonepasong Arounleut, Xin Wei, Ningxuan Zhou, Sudeepa Syamala, Frank P B Dubois, Alexander Crane, Kristine Pelton, Jayne Vogelzang, Cecilia Sousa, Audrey Baguette, Xiaolong Chen, Alexandra L Condurat, Sarah E Dixon-Clarke, Kevin N Zhou, Sophie D Lu, Elizabeth M Gonzalez, Madison S Chacon, Jeromy J Digiacomo, Rushil Kumbhani, Dana Novikov, J'Ya Hunter, Maria Tsoli, David S Ziegler, Uta Dirksen, Natalie Jager, Gnana Prakash Balasubramanian, Christof M Kramm, Michaela Nathrath, Stefan Bielack, Suzanne J Baker, Jinghui Zhang, James M McFarland, Gad Getz, Francois Aguet, Nada Jabado, Olaf Witt, Stefan M Pfister, Keith L Ligon, Claudia L Kleinman, Henry Long, David T W Jones, Pratiti Bandopadhayay, Timothy N Phoenix
BACKGROUND: Understanding how aberrant transcription factors (TFs) hijack normal development to induce oncogenesis is a critical question in oncology. Forkhead box (FOX) proteins are a superfamily of transcriptional regulators characterized by a fork
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d62d7fc7e751a4d28899955a247a5d
Autor:
Michelle Boisvert, Ashwyn A Perera, Alexandra L Condurat, John Jeang, Jessica W Tsai, Dana Novikov, Kevin Zhou, Madison Chacon, Jeromy DiGiacomo, Rushil Kumbhani, Dayle Wang, Michael D Taylor, Jordan R Hansford, Louise Ludlow, Nada Jabado, Keith L Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, David T W Jones
Publikováno v:
Neuro-Oncology. 24:i101-i102
Pediatric low-grade gliomas (pLGGs) are the most frequent brain tumors in children and comprise a heterogeneous group of tumors with different locations, histologic subtypes, ages at presentation, and clinical behavior. Tumors frequently respond to t