Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexandra Klevenz"'
Therapeutic vaccination using minimal HPV16 epitopes in a novel MHC-humanized murine HPV tumor model
Autor:
Sebastian Kruse, Marleen Büchler, Philipp Uhl, Max Sauter, Philipp Scherer, Tammy C.T. Lan, Samantha Zottnick, Alexandra Klevenz, Ruwen Yang, Frank Rösl, Walter Mier, Angelika B. Riemer
Publikováno v:
OncoImmunology, Vol 8, Iss 1 (2019)
Therapeutic vaccination as a treatment option for HPV-induced cancers is actively pursued because the two HPV proteins E6 and E7 represent ideal targets for immunotherapy, as they are non-self and expressed in all tumor stages. MHC-humanized mice are
Externí odkaz:
https://doaj.org/article/70be33e436ae4709be8dc841f40a66a6
Autor:
Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K. Grabowska, Angelika B. Riemer
Publikováno v:
OncoImmunology, Vol 6, Iss 7 (2017)
Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) compon
Externí odkaz:
https://doaj.org/article/ae6d5e86210647779ad336d1c562b115
Therapeutic vaccination using minimal HPV16 epitopes in a novel MHC-humanized murine HPV tumor model
Autor:
Philipp Scherer, Marleen Büchler, Samantha Zottnick, Max Sauter, Walter Mier, Sebastian Kruse, Tammy C.T. Lan, Frank Rösl, Ruwen Yang, Angelika B. Riemer, Philipp Uhl, Alexandra Klevenz
Publikováno v:
OncoImmunology, Vol 8, Iss 1 (2019)
Therapeutic vaccination as a treatment option for HPV-induced cancers is actively pursued because the two HPV proteins E6 and E7 represent ideal targets for immunotherapy, as they are non-self and expressed in all tumor stages. MHC-humanized mice are
Autor:
Alexandra Klevenz, Julia Ludwig, Bernd Arnold, Günter Küblbeck, Sandra Prokosch, Sabine Schmitt, Lars Nitschke, Hermann Josef Gröne, Giuseppina Federico
Publikováno v:
The Journal of Immunology. 194:2624-2634
The mechanisms responsible for the generation of a mature B1 and B2 cell compartment are still poorly understood. In this study, we demonstrated that absence of Dickkopf-3 (DKK3) led to changes in the composition of the B cell compartment, which were
Autor:
Renata Blatnik, Stephanie Hoppe, Miriam Bertrand, Alexandra Klevenz, Agnieszka K. Grabowska, Jan Winter, Magnus von Knebel Doeberitz, Alina Steinbach, Angelika B. Riemer, Miriam Reuschenbach
Publikováno v:
OncoImmunology, Vol 6, Iss 7 (2017)
Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) compon
Autor:
Gorana Hollmann, Günter Küblbeck, Gerhard Moldenhauer, Julia Ludwig, Thilo Oelert, Alexandra Klevenz, Anna Tafuri, Christof Niehrs, Bernd Arnold, Georg Pougialis, Maria Papatriantafyllou, Günter J. Hämmerling, Sabine Schmitt, Hermann Josef Gröne, Natalio Garbi
Publikováno v:
Proceedings of the National Academy of Sciences. 109:1631-1636
In healthy individuals, T cells react against incoming pathogens, but remain tolerant to self-antigens, thereby preventing autoimmune reactions. CD4 regulatory T cells are major contributors in induction and maintenance of peripheral tolerance, but a
Autor:
Sandra Prokosch, Tobias Bald, Thomas Tüting, Kun-Hui Lu, Naveen Shridhar, Bernd Arnold, Alexandra Klevenz, Amel Tounsi, Günter Küblbeck
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Frontiers in Immunology
Frontiers in Immunology
Mesenchymal stem cells (MSCs) are known to limit immune responses in vivo by multiple soluble factors. Dickkopf-3 (DKK3), a secreted glycoprotein, has recently been identified as a novel immune modulator. Since DKK3 has been reported to be produced b
Autor:
Edwige Roy, Friedhelm Bladt, Günter Küblbeck, Günter J. Hämmerling, Dieudonnée Togbe, Bernd Arnold, Frank Leithäuser, Amy D. Holdorf, Sabrina Nabti, Annette Kopp-Schneider, Alexandra Klevenz, Dmitry Trubetskoy, Peter Möller, Tony Pawson, Anna Tafuri
Publikováno v:
Proceedings of the National Academy of Sciences. 107:15529-15534
The size and sensitivity of the T-cell repertoire governs the effectiveness of immune responses against invading pathogens. Both are modulated by T-cell receptor (TCR) activity through molecular mechanisms, which remain unclear. Here, we provide gene
Autor:
Ulrike Kostezka, Frank Leithäuser, Facundo D. Batista, Sandra Prokosch, Georg Pougialis, Alexandra Klevenz, Bernd Arnold, Angelo Castello, Anna Tafuri, Sabine Schmitt, Günter Küblbeck, Kun-Hui Lu, Torsten Mattfeldt, Selina Jessica Keppler, Tony Pawson
Publikováno v:
Journal of leukocyte biology. 98(3)
Understanding the molecular mechanisms regulating T cell reactivity is required for successful reprogramming of immune responses in medical conditions, characterized by dysfunctions of the immune system. Nck proteins are cytoplasmic adaptors mediatin
Publikováno v:
Novartis Foundation Symposium 215-Immunological Tolerance
T lymphocytes with self-destructive capacity are often found in healthy individuals, indicating efficient control mechanisms that prevent autoimmunity. Recently, we were able to demonstrate the existence of peripheral tolerance in double-transgenic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4887df26b7be43fef385274eb59797de
https://doi.org/10.1002/9780470515525.ch14
https://doi.org/10.1002/9780470515525.ch14