Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alexandra Khitun"'
Publikováno v:
Bio-Protocol, Vol 13, Iss 1 (2023)
RIBO-seq and proteogenomics have revealed that mammalian genomes harbor thousands of unannotated small and alternative open reading frames (smORFs, 100 amino acids, respectively). Several dozen mammalian smORF-encoded proteins (SEPs) and alt-ORF-enco
Externí odkaz:
https://doaj.org/article/79c181306be44cc48ee5b28e4c24dae8
Autor:
Xiongwen Cao, Alexandra Khitun, Yang Luo, Zhenkun Na, Thitima Phoodokmai, Khomkrit Sappakhaw, Elizabeth Olatunji, Chayasith Uttamapinant, Sarah A. Slavoff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Many alternative ORFs are co-encoded with characterized proteins, but their function is often not understood. Here, the authors discover that ribosomal protein L36 is co-encoded with alternative protein, which they identify as an upstream regulator o
Externí odkaz:
https://doaj.org/article/091905a115924482b3ee4fbf7e8b7e99
Autor:
Erin E. Duffy, Benjamin Finander, GiHun Choi, Ava C. Carter, Iva Pritisanac, Aqsa Alam, Victor Luria, Amir Karger, William Phu, Maxwell A. Sherman, Elena G. Assad, Naomi Pajarillo, Alexandra Khitun, Elizabeth E. Crouch, Sanika Ganesh, Jin Chen, Bonnie Berger, Nenad Sestan, Anne O’Donnell-Luria, Eric J. Huang, Eric C. Griffith, Julie D. Forman-Kay, Alan M. Moses, Brian T. Kalish, Michael E. Greenberg
Publikováno v:
Nature neuroscience, vol 25, iss 10
The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although several studies have profiled transcription in the developing human brain, there is a gap in understanding of accompanying trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f1812dea783a335dcb51a8256cbbf1
https://escholarship.org/uc/item/6gc2q79k
https://escholarship.org/uc/item/6gc2q79k
Autor:
Sarah A. Slavoff, Matthew D. Simon, Sowndarya Muthukumar, Alexandra Khitun, Yang Luo, Jeremy A. Schofield, Zhenkun Na, Stephanie Smelyansky, Eugene Valkov
Publikováno v:
Biochemistry
Proteogenomic identification of translated small open reading frames in human has revealed thousands of microproteins, or polypeptides of fewer than 100 amino acids, that were previously invisible to geneticists. Hundreds of microproteins have been s
Autor:
Sanika Ganesh, William Phu, Aqsa Alam, Julie D. Forman-Kay, Eric J. Huang, Alexandra Khitun, Elizabeth E. Crouch, Eric C. Griffith, Elena G. Assad, GiHun Choi, Anne H. O’Donnell-Luria, Nenad Sestan, Maxwell A. Sherman, Ava C. Carter, Alan M. Moses, Amir Karger, Bonnie Berger, Brian T. Kalish, Victor Luria, Iva Pritišanac, Benjamin Finander, Erin E. Duffy, Michael E. Greenberg
The precise regulation of gene expression is fundamental to neurodevelopment, plasticity, and cognitive function. While several studies have deeply profiled mRNA dynamics in the developing human brain, there is a fundamental gap in our understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08d1af5dee3c958061ffb62801358533
https://doi.org/10.1101/2021.10.22.465170
https://doi.org/10.1101/2021.10.22.465170
Autor:
Cecelia M. Harold, Sarah A. Slavoff, Alexandra Khitun, Xiongwen Cao, Susan J. Baserga, Carson J. Bryant, Shu-Jian Zheng
Many unannotated microproteins and alternative proteins (alt-proteins) have recently been found to be co-encoded with canonical proteins, but few of their functions are known. Motivated by the hypothesis that alt-proteins undergoing active or stress-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2855dbe3113137f7a93116343b8fcbd8
https://doi.org/10.21203/rs.3.rs-871945/v1
https://doi.org/10.21203/rs.3.rs-871945/v1
Autor:
Xiongwen Cao, Alexandra Khitun, Cecelia M. Harold, Carson J. Bryant, Shu-Jian Zheng, Susan J. Baserga, Sarah A. Slavoff
Publikováno v:
Nature chemical biology. 18(6)
Many unannotated microproteins and alternative proteins (alt-proteins) are coencoded with canonical proteins, but few of their functions are known. Motivated by the hypothesis that alt-proteins undergoing regulated synthesis could play important cell
Autor:
Alexandra Khitun, Stephanie Smelyansky, Yang Luo, D.S. Cui, Sarah A. Slavoff, J. Patrick Loria, Zhenkun Na
Publikováno v:
J Am Chem Soc
Proteogenomic identification of translated small open reading frames in humans has revealed thousands of microproteins, or polypeptides of fewer than 100 amino acids, that were previously invisible to geneticists. Hundreds of microproteins have been
Autor:
J. Patrick Loria, DanicaS. Cui, Stephanie Smelyansky, Sarah A. Slavoff, Alexandra Khitun, Zhenkun Na, Yang Luo
This study reports detection of specific phosphorylation sites installed on a small open reading frame-encoded polypeptide or microprotein called NBDY. NBDY phosphorylation sites were mapped using phosphoproteomics and antibody-based validation. NBDY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb57555523f2d201779b9a061d2a5d83
https://doi.org/10.26434/chemrxiv.14632611
https://doi.org/10.26434/chemrxiv.14632611
Autor:
Mathias H. Skadow, Angel G. Solis, Abigail Jarret, J Richard Brewer, Alexandra Khitun, Holly R. Steach, Omair Khan, Will Bailis, Richard A. Flavell, Autumn G. York, Lina Kroehling, Ruaidhri Jackson, Christian C. D. Harman, Piotr Bielecki, Lelina Chang, Coco Duizer, Sarah A. Slavoff
Publikováno v:
Nature
The annotation of the mammalian protein coding genome is incomplete. Arbitrary open reading frame (ORF) size restriction and the absolute requirement for a methionine codon as the sole initiator of translation, have constrained identification of pote