Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alexandra Kegler"'
Autor:
Liliana R. Loureiro, Lydia Hoffmann, Christin Neuber, Luise Rupp, Claudia Arndt, Alexandra Kegler, Manja Kubeil, Christoph E. Hagemeyer, Holger Stephan, Marc Schmitz, Anja Feldmann, Michael Bachmann
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies. Yet, their effectiveness is limited when tackling solid tumors, where immune cell infilt
Externí odkaz:
https://doaj.org/article/40cdac5b7b9a489091bc53905b399ab5
Autor:
Karla E. G. Soto, Liliana R. Loureiro, Tabea Bartsch, Claudia Arndt, Alexandra Kegler, Nicola Mitwasi, Laura Drewitz, Lydia Hoffmann, Haidy A. Saleh, Eugenia Crespo, Maria Mehnert, Cansu Daglar, Hinrich Abken, Frank Momburg, Michael Bachmann, Anja Feldmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Despite the success of chimeric antigen receptor (CAR) T-cells especially for treating hematological malignancies, critical drawbacks, such as “on-target, off-tumor” toxicities, need to be addressed to improve safety in translating to clinical ap
Externí odkaz:
https://doaj.org/article/504decca751c445b97cdaa60cf18debc
Autor:
Alexandra Kegler, Laura Drewitz, Claudia Arndt, Cansu Daglar, Liliana Rodrigues Loureiro, Nicola Mitwasi, Christin Neuber, Karla Elizabeth González Soto, Tabea Bartsch, Larysa Baraban, Holger Ziehr, Markus Heine, Annabel Nieter, Andres Moreira-Soto, Arne Kühne, Jan Felix Drexler, Barbara Seliger, Markus Laube, Domokos Máthé, Bernadett Pályi, Polett Hajdrik, László Forgách, Zoltán Kis, Krisztián Szigeti, Ralf Bergmann, Anja Feldmann, Michael Bachmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to millions of infections and deaths worldwide. As this virus evolves rapidly, there is a high need for treatment options that
Externí odkaz:
https://doaj.org/article/6f9dbf914b914345892894df2414c939
Autor:
Haidy A. Saleh, Nicola Mitwasi, Martin Ullrich, Manja Kubeil, Magali Toussaint, Winnie Deuther-Conrad, Christin Neuber, Claudia Arndt, Liliana R. Loureiro, Alexandra Kegler, Karla Elizabeth González Soto, Birgit Belter, Claudia Rössig, Jens Pietzsch, Marcus Frenz, Michael Bachmann, Anja Feldmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Glioblastoma (GBM) is still an incurable tumor that is associated with high recurrence rate and poor survival despite the current treatment regimes. With the urgent need for novel therapeutic strategies, immunotherapies, especially chimeric antigen r
Externí odkaz:
https://doaj.org/article/869c24c8ece440448383f3d31672b966
Autor:
Diana Lindner, Claudia Arndt, Liliana Rodrigues Loureiro, Anja Feldmann, Alexandra Kegler, Stefanie Koristka, Nicole Berndt, Nicola Mitwasi, Ralf Bergmann, Marcus Frenz, Michael P. Bachmann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7922 (2022)
Radiation of tumor cells can lead to the selection and outgrowth of tumor escape variants. As radioresistant tumor cells are still sensitive to retargeting of T cells, it appears promising to combine radio- with immunotherapy keeping in mind that the
Externí odkaz:
https://doaj.org/article/2c4bf13138b44996817bbaeb1cfed308
Autor:
Nicola Mitwasi, Claudia Arndt, Liliana R. Loureiro, Alexandra Kegler, Frederick Fasslrinner, Nicole Berndt, Ralf Bergmann, Vaclav Hořejší, Claudia Rössig, Michael Bachmann, Anja Feldmann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4920 (2022)
Chimeric antigen receptor (CAR)-expressing T-cells are without a doubt a breakthrough therapy for hematological malignancies. Despite their success, clinical experience has revealed several challenges, which include relapse after targeting single ant
Externí odkaz:
https://doaj.org/article/e3db933984b54b74941f83245e288cf4
Autor:
Claudia Arndt, Liliana R. Loureiro, Anja Feldmann, Justyna Jureczek, Ralf Bergmann, Domokos Máthé, Nikolett Hegedüs, Nicole Berndt, Stefanie Koristka, Nicola Mitwasi, Frederick Fasslrinner, Chris Lamprecht, Alexandra Kegler, Anja Hoffmann, Tabea Bartsch, Ayşe Sedef Köseer, Gary Egan, Marc Schmitz, Vaclav Hořejší, Mechthild Krause, Anna Dubrovska, Michael Bachmann
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Induction or selection of radioresistant cancer (stem) cells following standard radiotherapy is presumably one of the major causes for recurrence of metastatic disease. One possibility to prevent tumor relapse is the application of targeted immunothe
Externí odkaz:
https://doaj.org/article/e9bde3c3ab474cab96ef8a34e0e398cf
Autor:
Anja Feldmann, Anja Hoffmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Claudia Arndt, Liliana Rodrigues Loureiro, Enrico Kittel-Boselli, Nicola Mitwasi, Alexandra Kegler, Chris Lamprecht, Karla Elizabeth González Soto, Michael Bachmann
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Chimeric antigen receptor (CAR) T cells show remarkable therapeutic effects in some hematological malignancies. However, CAR T cells can also cause life-threatening side effects. In order to minimize off-target and on-target/off-tumor reactions, impr
Externí odkaz:
https://doaj.org/article/bc91c804ed64427db2befd76169ff87f
Autor:
Claudia Arndt, Anja Feldmann, Stefanie Koristka, Martin Schäfer, Ralf Bergmann, Nicola Mitwasi, Nicole Berndt, Dominik Bachmann, Alexandra Kegler, Marc Schmitz, Edinson Puentes-Cala, Javier Andrés Soto, Gerhard Ehninger, Jens Pietzsch, Christos Liolios, Gerd Wunderlich, Jörg Kotzerke, Klaus Kopka, Michael Bachmann
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Chimeric antigen receptor (CAR) T cells have shown impressive therapeutic potential. Due to the lack of direct control mechanisms, therapy-related adverse reactions including cytokine release- and tumor lysis syndrome can even become life-threatening
Externí odkaz:
https://doaj.org/article/548a1789fc034041a40e5322349578b0
Autor:
Tabea Bartsch, Claudia Arndt, Liliana R. Loureiro, Alexandra Kegler, Edinson Puentes-Cala, Javier Andrés Soto, Biji T. Kurien, Anja Feldmann, Nicole Berndt, Michael P. Bachmann
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 12046 (2021)
The anti-La mab 312B, which was established by hybridoma technology from human-La transgenic mice after adoptive transfer of anti-human La T cells, immunoprecipitates both native eukaryotic human and murine La protein. Therefore, it represents a true
Externí odkaz:
https://doaj.org/article/81bdb80441084ae9a22ff72a15acbb10