Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Alexandra K. Kiemer"'
Autor:
Vida Mashayekhi, Annika Schomisch, Sari Rasheed, Ernesto Aparicio-Puerta, Timo Risch, Daniela Yildiz, Marcus Koch, Simon Both, Nicole Ludwig, Thierry M. Legroux, Andreas Keller, Rolf Müller, Gregor Fuhrmann, Jessica Hoppstädter, Alexandra K. Kiemer
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-25 (2024)
Abstract Background Tumor cells release extracellular vesicles (EVs) that contribute to the polarization of macrophages towards tumor-associated macrophages (TAMs). High expression levels of the RNA binding protein IGF2BP2/IMP2 are correlated with in
Externí odkaz:
https://doaj.org/article/52238bc27ac04c37bc483fbc3f29b0e9
Autor:
Thierry M. Legroux, Hanna S. Schymik, Gilles Gasparoni, Saeed Mohammadi, Jörn Walter, Claude Libert, Britta Diesel, Jessica Hoppstädter, Alexandra K. Kiemer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Glucocorticoids, which have long served as fundamental therapeutics for diverse inflammatory conditions, are still widely used, despite associated side effects limiting their long-term use. Among their key mediators is glucocorticoid-induced leucine
Externí odkaz:
https://doaj.org/article/aa245194554e4575ad448d13c8c14fd7
Autor:
Anne S. Boewe, Selina Wrublewsky, Jessica Hoppstädter, Claudia Götz, Alexandra K. Kiemer, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102120- (2024)
Nerve/glial antigen (NG)2 is highly expressed in glioblastoma multiforme (GBM). However, the underlying mechanisms of its upregulated expression are largely unknown. In silico analyses reveal that the tumor-suppressive miR-29b targets NG2. We used GB
Externí odkaz:
https://doaj.org/article/46ee46c139cf4f2ca688679e893a28a9
Autor:
Ranjan Kumar Maji, Beate Czepukojc, Michael Scherer, Sascha Tierling, Cristina Cadenas, Kathrin Gianmoena, Nina Gasparoni, Karl Nordström, Gilles Gasparoni, Stephan Laggai, Xinyi Yang, Anupam Sinha, Peter Ebert, Maren Falk-Paulsen, Sarah Kinkley, Jessica Hoppstädter, Ho-Ryun Chung, Philip Rosenstiel, Jan G. Hengstler, Jörn Walter, Marcel H. Schulz, Sonja M. Kessler, Alexandra K. Kiemer
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known
Externí odkaz:
https://doaj.org/article/08abcdc296d74786a777114970ddef43
Autor:
Sandra Kendzia, Susanne Franke, Tarek Kröhler, Nicole Golob-Schwarzl, Caroline Schweiger, Anna M. Toeglhofer, Christina Skofler, Stefan Uranitsch, Amin El-Heliebi, Julia Fuchs, Andreas Punschart, Philipp Stiegler, Marlen Keil, Jens Hoffmann, David Henderson, Hans Lehrach, Marie-Laure Yaspo, Christoph Reinhard, Reinhold Schäfer, Ulrich Keilholz, Christian Regenbrecht, Rudolf Schicho, Peter Fickert, Sigurd F. Lax, Frank Erdmann, Marcel H. Schulz, Alexandra K. Kiemer, Johannes Haybaeck, Sonja M. Kessler
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Aim Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC chemoresistance was investigated using in silico, in vitro, and in vi
Externí odkaz:
https://doaj.org/article/8de696616f90444eab4aecca58af009f
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/6252113efdd9459ba50592c0a9d3a416
Autor:
Shilpee Chanda, Konstantin Lepikhov, Charlotte Dahlem, Hanna S. Schymik, Jessica Hoppstädter, An-Kristin Geber, Konrad Wagner, Sonja M. Kessler, Martin Empting, Alexandra K. Kiemer
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 41 (2024)
Background: The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is an oncofetal protein that is overexpressed in several cancer entities. Employing IMP2 knockout colorectal cancer cells, we could show the important role of IMP2 in several hallmarks of ca
Externí odkaz:
https://doaj.org/article/89d6e122b66b49bd99ed274709c6606a
Autor:
Salma Al-Fityan, Britta Diesel, Thorben Fischer, Emmanuel Ampofo, Annika Schomisch, Vida Mashayekhi, Marc Schneider, Alexandra K. Kiemer
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1895 (2023)
Macrophages (MΦs) in their pro-inflammatory state (M1) suppress tumour growth, while tumour-associated MΦs (TAMs) can promote tumour progression. The aim of this study was to test the hypothesis that targeted delivery of the immune activator poly(I
Externí odkaz:
https://doaj.org/article/73a87c15b9b542889769c634b9392297
Autor:
Amanda A. Wiesenthal, Thierry M. Legroux, Chris Richter, Björn H. Junker, Anne Hecksteden, Sonja M. Kessler, Jessica Hoppstädter, Alexandra K. Kiemer
Publikováno v:
Biology, Vol 12, Iss 4, p 530 (2023)
(1) Background: Aging is linked to an altered immune response and metabolism. Inflammatory conditions, such as sepsis, COVID-19, and steatohepatitis are more prevalent in the elderly and steatosis is linked both to severe COVID-19 and sepsis. We hypo
Externí odkaz:
https://doaj.org/article/d05e3fc0216743668f237d5ed44b68aa
Autor:
Charlotte Dahlem, Shilpee Chanda, Jan Hemmer, Hanna S. Schymik, Michael Kohlstedt, Christoph Wittmann, Alexandra K. Kiemer
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Natural products have been shown to serve as promising starting points for novel anti-cancer drugs. In this study, the anti-cancer activities of the purple compound violacein, initially isolated from Chromobacterium violaceum, were investigated. To h
Externí odkaz:
https://doaj.org/article/e9761f6f239f474088ddfc997384fc7f