Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alexandra K Brooks"'
Autor:
Alexandra K Brooks, Marcus A Lawson, Jennifer L Rytych, Kevin C Yu, Tiffany M Janda, Andrew J Steelman, Robert H McCusker
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Elevated levels of circulating pro-inflammatory cytokines are associated with symptomology of several psychiatric disorders, notably major depressive disorder. Symptomology has been linked to inflammation/cytokine-dependent induction of the Kynurenin
Externí odkaz:
https://doaj.org/article/e620107f2afb4c94a02034380d2bcf0f
Autor:
Colin K.W. Lim, Michael Gapinske, Alexandra K. Brooks, Wendy S. Woods, Jackson E. Powell, M. Alejandra Zeballos C., Jackson Winter, Pablo Perez-Pinera, Thomas Gaj
Publikováno v:
Mol Ther
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal disorder that can be caused by mutations in the superoxide dismutase 1 (SOD1) gene. Although ALS is currently incurable, CRISPR base editors hold the potential to treat the disease throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad39aef6113c3b3ae2a68010bba5a83
https://doi.org/10.1016/j.ymthe.2020.01.005
https://doi.org/10.1016/j.ymthe.2020.01.005
Autor:
Gregory G. Freund, Robert H. McCusker, Alexandra K. Brooks, Andrew J. Steelman, Albert E. Towers, M. Juda
Publikováno v:
Epilepsia. 60:626-635
OBJECTIVE Viral encephalitis increases the risk for developing seizures and epilepsy. Indoleamine 2,3-dioxygenase 1 (Ido1) is induced by inflammatory cytokines and functions to metabolize tryptophan to kynurenine. Kynurenine can be further metabolize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38904b817a5a9ed341bb3acf08867a88
https://doi.org/10.1111/epi.14675
https://doi.org/10.1111/epi.14675
Autor:
Thomas Gaj, Alexandra K. Brooks
Publikováno v:
Current opinion in biotechnology. 52
CRISPR-Cas9 is a versatile tool for genome engineering that has revolutionized biotechnology and is poised to impact medicine. Recent advances in the identification of unique CRISPR systems, as well as the re-engineering of the Cas9 protein for expan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a79e8ac6a423823c512736d06658b4
https://pubmed.ncbi.nlm.nih.gov/29626736
https://pubmed.ncbi.nlm.nih.gov/29626736
Autor:
Robert H. McCusker, Alexandra K. Brooks, Gregory G. Freund, Andrew J. Steelman, Marcus A. Lawson
Publikováno v:
Brain, Behavior, and Immunity. 81:44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beb46aee7b174818c4b6cb0941374ca1
https://doi.org/10.1016/j.bbi.2019.08.146
https://doi.org/10.1016/j.bbi.2019.08.146
Autor:
Marcus A. Lawson, Alexandra K. Brooks, Jennifer L. Rytych, Robin A. Smith, Cecilia Ocampo-Solis, Tiffany M. Janda, Robert H. McCusker
Publikováno v:
Brain, behavior, and immunity. 62
Abundant evidence connects depression symptomology with immune system activation, stress and subsequently elevated levels of kynurenine. Anti-depressants, such as the tricyclic norepinephrine/serotonin reuptake inhibitor desipramine (Desip), were dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8df2ee0325264058fc952aef6fa26a
https://pubmed.ncbi.nlm.nih.gov/28212884
https://pubmed.ncbi.nlm.nih.gov/28212884
Autor:
Gregory G. Freund, Andrew J. Steelman, M. Juda, Robert H. McCusker, Alexandra K. Brooks, Albert E. Towers
Publikováno v:
Brain, Behavior, and Immunity. 57:e42
Viral encephalitis (VE) is a life-threatening condition that can be triggered by infection with a multitude of different viruses including members of Picornaviridae. There are few treatment options for VE and the mechanisms that influence prognosis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a0527cf056816df0340f00756500cf1
https://doi.org/10.1016/j.bbi.2016.07.138
https://doi.org/10.1016/j.bbi.2016.07.138
Autor:
Keith W. Kelley, Marcus A. Lawson, Alexandra K. Brooks, Tiffany M. Janda, Robert H. McCusker, Robin A. Smith
Publikováno v:
Journal of Neuroinflammation
Background Increased tryptophan metabolism towards the production of kynurenine via indoleamine/tryptophan-2,3-dioxygenases (DOs: Ido1, Ido2, and Tdo2) is strongly associated with the prevalence of major depressive disorder in patients and the induct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e377a93e9fd2faf433df2e2c55fa2386