Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexandra J. Machen"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, in
Externí odkaz:
https://doaj.org/article/3f8e058c49e347208faec432f78c2113
Autor:
Pierce T. O'Neil, Alexandra J. Machen, Benjamin C. Deatherage, Caleb Trecazzi, Alexander Tischer, Venkata R. Machha, Matthew T. Auton, Michael R. Baldwin, Tommi A. White, Mark T. Fisher
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
The nucleotide-free chaperonin GroEL is capable of capturing transient unfolded or partially unfolded states that flicker in and out of existence due to large-scale protein dynamic vibrational modes. In this work, three short vignettes are presented
Externí odkaz:
https://doaj.org/article/a870c8a57acf4a8c80dd837c14933afb
Autor:
Alexandra J. Machen, Narahari Akkaladevi, Caleb Trecazzi, Pierce T. O’Neil, Srayanta Mukherjee, Yifei Qi, Rebecca Dillard, Wonpil Im, Edward P. Gogol, Tommi A. White, Mark T. Fisher
Publikováno v:
Toxins, Vol 9, Iss 10, p 298 (2017)
The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease. To better understa
Externí odkaz:
https://doaj.org/article/fede19d32f3a48ffa74c7d3b15e73737
Autor:
Chamandi S. Dampalla, Harry Nhat Nguyen, Athri D. Rathnayake, Yunjeong Kim, Krishani Dinali Perera, Trent K. Madden, Hayden A. Thurman, Alexandra J. Machen, Maithri M. Kashipathy, Lijun Liu, Kevin P. Battaile, Scott Lovell, Kyeong-Ok Chang, William C. Groutas
Publikováno v:
ACS Pharmacology & Translational Science. 6:181-194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dfd5a98cb044d01fc1d704fa8f0de58
https://doi.org/10.1021/acsptsci.2c00206
https://doi.org/10.1021/acsptsci.2c00206
Autor:
Chamandi S. Dampalla, Matthew J. Miller, Yunjeong Kim, Alexandria Zabiegala, Harry Nhat Nguyen, Trent K. Madden, Hayden A. Thurman, Alexandra J. Machen, Anne Cooper, Lijun Liu, Kevin P. Battaile, Scott Lovell, Kyeong-Ok Chang, William C. Groutas
Publikováno v:
European Journal of Medicinal Chemistry. 254:115376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a75b9580fac49a9aab4eb1d9fc74881
https://doi.org/10.1016/j.ejmech.2023.115376
https://doi.org/10.1016/j.ejmech.2023.115376
Autor:
Alexandra J Machen, Mark T. Fisher, Wendy A. Lea, Karen R. Khar, Matthew Auton, Alexander Tischer, Pierce T. O’Neil, Subhashchandra Naik, Tapan Chaudhri, Wesley Mcginn-Straub, John Karanicolas, Joshua R. Burns, Michael R. Baldwin
Publikováno v:
Biochemistry. 55:4885-4908
Stabilizing the folded state of metastable and/or aggregation-prone proteins through exogenous ligand binding is an appealing strategy for decreasing disease pathologies caused by protein folding defects or deleterious kinetic transitions. Current me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96424c6b9eef2d3519b3cee8899fe9ed
https://doi.org/10.1021/acs.biochem.6b00293
https://doi.org/10.1021/acs.biochem.6b00293
Autor:
Mark T. Fisher, Alexandra J Machen, John Karanicolas, Quyen Q. Hoang, Wei Wang, Michael R. Baldwin, Karen R. Khar, Jackie A. Thompson, Pierce T. O’Neil
Publikováno v:
Methods in Molecular Biology ISBN: 9781493988198
Methods to assess the kinetic stability of proteins, particularly those that are aggregation prone, are very useful in establishing ligand induced stabilizing effects. Because aggregation prone proteins are by nature difficult to work with, most solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a33d0f641464e3ab5855db3f1528bde
https://doi.org/10.1007/978-1-4939-8820-4_19
https://doi.org/10.1007/978-1-4939-8820-4_19
Autor:
Bradley L. Pentelute, Alexandra J Machen, Mark T. Fisher, Pierce T. O’Neil, Maria T. Villar, Antonio Artigues
Publikováno v:
Journal of Visualized Experiments (JOVE)
In vivo, proteins are often part of large macromolecular complexes where binding specificity and dynamics ultimately dictate functional outputs. In this work, the pre-endosomal anthrax toxin is assembled and transitioned into the endosomal complex. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b4cfa3b43b0b8417f70f6902dc3aa5
https://doi.org/10.3791/57902-v
https://doi.org/10.3791/57902-v
Autor:
Edward P. Gogol, Alexandra J Machen, Yifei Qi, Srayanta Mukherjee, Tommi A. White, Rebecca Dillard, Caleb Trecazzi, Wonpil Im, Pierce T. O’Neil, Narahari Akkaladevi, Mark T. Fisher
Publikováno v:
Toxins, Vol 9, Iss 10, p 298 (2017)
Toxins
Toxins; Volume 9; Issue 10; Pages: 298
Toxins
Toxins; Volume 9; Issue 10; Pages: 298
The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease. To better understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dda37b6ac697553b1451c0e848dcba
https://www.mdpi.com/2072-6651/9/10/298
https://www.mdpi.com/2072-6651/9/10/298
Publikováno v:
Microscopy and Microanalysis. 23:1256-1257
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9068ed68410286c065b4b44086944c7
https://doi.org/10.1017/s1431927617006948
https://doi.org/10.1017/s1431927617006948