Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Alexandra J. Harvey"'
Publikováno v:
Fertility & Reproduction, Vol 04, Iss 03n04, Pp 162-162 (2022)
Background: Embryo culture and cryopreservation causes detrimental effects on blastocyst gene expression. While combined antioxidants (acetyl-L-carnitine/N-acetyl-L-cysteine/[Formula: see text]-lipoic acid (A3)) in culture and vitrification media hav
Externí odkaz:
https://doaj.org/article/713a0bcf3b434d9ab46b39b72eeb560b
Publikováno v:
Fertility & Reproduction, Vol 04, Iss 03n04, Pp 168-168 (2022)
Background: Diet-induced nutritional changes in the maternal reproductive tract stimulate embryonic adaptations to maintain growth and survival, directly impacting child and adult health via developmental programming. This is plausibly facilitated by
Externí odkaz:
https://doaj.org/article/7f868f5ff85c4b17b4ada2ac86116914
Publikováno v:
Fertility & Reproduction, Vol 04, Iss 03n04, Pp 134-134 (2022)
Background: At the time of implantation, the blastocyst produces a significant amount of lactic acid (LA), creating a microenvironment characterized by high lactate and low pH. Historically considered a ‘by-product’ of metabolism, studies have re
Externí odkaz:
https://doaj.org/article/f7180d97d3ea40a798fc87cd106453f7
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Reprogramming to pluripotency involves drastic restructuring of both metabolism and the epigenome. However, induced pluripotent stem cells (iPSC) retain transcriptional memory, epigenetic memory, and metabolic memory from their somatic cells of origi
Externí odkaz:
https://doaj.org/article/0ffc2e0bc8424c67aab1e40e58847142
Autor:
Jarmon G. Lees, Timothy S. Cliff, Amanda Gammilonghi, James G. Ryall, Stephen Dalton, David K. Gardner, Alexandra J. Harvey
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Metabolism has been shown to alter cell fate in human pluripotent stem cells (hPSC). However, current understanding is almost exclusively based on work performed at 20% oxygen (air), with very few studies reporting on hPSC at physiological oxygen (5%
Externí odkaz:
https://doaj.org/article/d4ec25afe2aa43ad8936bfbf4d7a5ecd
Autor:
Jarmon G. Lees, Anne M. Kong, Yi C. Chen, Priyadharshini Sivakumaran, Damián Hernández, Alice Pébay, Alexandra J. Harvey, David K. Gardner, Shiang Y. Lim
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Human induced pluripotent stem cells (iPSCs) can be differentiated in vitro into bona fide cardiomyocytes for disease modelling and personalized medicine. Mitochondrial morphology and metabolism change dramatically as iPSCs differentiate into mesoder
Externí odkaz:
https://doaj.org/article/85ccbf95dccf420887dafb2aa41ba1df
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. The significance of altered nutrient availabilit
Externí odkaz:
https://doaj.org/article/0e812618dc394fffac4192d7d3df70bf
Publikováno v:
Stem Cells International, Vol 2016 (2016)
The differentiation of pluripotent stem cells is associated with extensive changes in metabolism, as well as widespread remodeling of the epigenetic landscape. Epigenetic regulation is essential for the modulation of differentiation, being responsibl
Externí odkaz:
https://doaj.org/article/e7baa5fec9184a56958d0e1f3082a763
Publikováno v:
Reproductive BioMedicine Online. 46:20-33
Does the ketone acetoacetate (AcAc) alone, or combined with β-hydroxybutyrate (βOHB), impact mouse embryo development, metabolism, histone acetylation and viability?Pronucleate mouse oocytes were cultured in vitro in G1/G2 media supplemented with k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e464620dfe44d55ebb0fd4ad85cfa8e8
https://doi.org/10.1016/j.rbmo.2022.09.018
https://doi.org/10.1016/j.rbmo.2022.09.018
Publikováno v:
Reproductive BioMedicine Online. 44:393-410
What is the effect on mouse fetal gene expression of combined antioxidants (acetyl-L-carnitine, N-acetyl-L-cysteine and alpha-lipoic acid; A3) when used in culture media and vitrification/warming solutions?A laboratory-based analysis of an animal mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800d91daa00ce8de44861b3576305c4c
https://doi.org/10.1016/j.rbmo.2021.11.013
https://doi.org/10.1016/j.rbmo.2021.11.013