Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexandra J. Gadiano"'
Autor:
Kathryn M. Lemberg, Rana Rais, Ranjeet Prasad Dash, Kateřina Novotná, Jesse Alt, Pavel Majer, Barbara S. Slusher, Lukáš Tenora, Alexandra J. Gadiano, Quinn R. Kirkpatrick, Jenny Lam, Vijayabhaskar Veeravalli
Publikováno v:
J Med Chem
6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist with robust anticancer efficacy; however, its therapeutic potential was hampered by its biodistribution and toxicity to normal tissues, specifically gastrointestinal (GI) tissues. To circumve
Autor:
Ewa Galaj, Zhi Bing You, Vivek Kumar, Rana Rais, Zheng-Xiong Xi, Jianjing Cao, Guo Hua Bi, Amy Hauck Newman, Barbara S. Slusher, Eliot L. Gardner, Alexandra J. Gadiano
Publikováno v:
Neuropsychopharmacology. 44:1415-1424
Prescription opioids such as oxycodone are highly effective analgesics for clinical pain management, but their misuse and abuse have led to the current opioid epidemic in the United States. In order to ameliorate this public health crisis, the develo
Autor:
Jianjing Cao, Janaina C. M. Vendruscolo, Rana Rais, Alexandra J. Gadiano, Leandro F. Vendruscolo, Brooke E. Schmeichel, Rachel D. Slack, Chelsea P. Ho, Gianluigi Tanda, Brendan J. Tunstall, Amy Hauck Newman, George F. Koob, Barbara S. Slusher
Publikováno v:
Neuropharmacology. 131:96-103
Methamphetamine (METH) is a highly addictive drug, but no pharmacological treatment is yet available for METH use disorders. Similar to METH, the wake-promoting drug (R)- modafinil (R-MOD) binds to the dopamine transporter (DAT). Unlike METH, R-MOD i
Autor:
Norman J. Haughey, Ying Wu, Jiadi Xu, Arena A. Manning, Saja H Khuder, Justin C. McArthur, Ajit G. Thomas, Barbara S. Slusher, Rana Rais, Michael T. Nedelcovych, David J. Volsky, Alexandra J. Gadiano, Seung-Wan Yoo
Publikováno v:
ACS Chemical Neuroscience. 9:809-816
Insulin delivery to the brain has emerged as an important therapeutic target for cognitive disorders associated with abnormal brain energy metabolism. Although insulin is transported across the blood–brain barrier, peripheral routes of administrati
Autor:
Abhijit A. Date, Pranjali Kanvinde, Sarah C. Zimmermann, Barbara S. Slusher, Alexandra J. Gadiano, Ajit G. Thomas, Taarika Babu, Laura M. Ensign, Rana Rais, Jairo Ortiz, Gilad Halpert
Publikováno v:
Journal of Controlled Release. 263:132-138
Here we evaluate the potential for local administration of a small molecule FOLH1/GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) as a novel treatment for inflammatory bowel disease (IBD). We found that FOLH1/GCPII enzyme activity was in
Autor:
Barbara S. Slusher, Jianjing Cao, Alexandra J. Gadiano, Rana Rais, JoLynn B. Giancola, Alessandro Bonifazi, Claus J. Loland, Mark A. Coggiano, Therese Ku, Jenny Lam, Rachel D. Slack, Gianluigi Tanda, Amy Hauck Newman
Publikováno v:
J Med Chem
Atypical dopamine transporter (DAT) inhibitors have shown therapeutic potential in preclinical models of psychostimulant abuse. In rats, 1-(4-(2-((bis(4-fluorophenyl)methyl)sulfinyl)ethyl)-piperazin-1-yl)-propan-2-ol (3b) was effective in reducing th
Autor:
Zheng-Xiong Xi, Sophie L. Cemaj, Alexandra J. Gadiano, Anver Basha Shaik, Rana Rais, Jenny Lam, Vivek Kumar, Amy Hauck Newman, Barbara S. Slusher, Adrian M. Guerrero, Alessandro Bonifazi
Publikováno v:
J Med Chem
Dopamine D(3) receptors (D(3)R) play a critical role in neuropsychiatric conditions including substance use disorders (SUD). Recently, we reported a series of N-(3-hydroxy-4-(4-phenylpiperazin-1yl)butyl)-1H-indole-2-carboxamide analogues as high affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5f4d9f85fc14b5f81fc7f0712360f6
https://europepmc.org/articles/PMC8830247/
https://europepmc.org/articles/PMC8830247/
Autor:
Guo Hua Bi, Chloe J. Jordan, Zheng-Xiong Xi, Anver Basha Shaik, Jianjing Cao, Myra Rice, Barbara S. Slusher, Rana Rais, Alessandro Bonifazi, Zhi Bing You, Alexandra J. Gadiano, Amy Hauck Newman, Bree A. Humburg
Publikováno v:
Neuropharmacology. 158:107597
Prescription opioid abuse is a global crisis. New treatment strategies for pain and opioid use disorders are urgently required. We evaluated the effects of R-VK4-40, a highly selective dopamine (DA) D3 receptor (D3R) antagonist, on the rewarding and
Autor:
Alessia Chiorazzi, Ying Wu, Rana Rais, Virginia Rodriguez-Menendez, Krystyna M. Wozniak, Michael Polydefkis, Eleonora Pozzi, Annalisa Canta, Mohamed H. Farah, Guido Cavaletti, Cristina Meregalli, Alexandra J. Gadiano, Barbara S. Slusher, Paola Alberti, Laura Monza, G Fumagalli, James J. Vornov, Ying Liu, Claudio Pietra
Publikováno v:
European journal of pharmacology. 840
Chemotherapy-Induced Peripheral Neurotoxicity (CIPN) is often dose-limiting and impacts life quality and survival of cancer patients. Ghrelin agonists have neuroprotectant effects and may have a role in treating or preventing CIPN. We evaluated the C
Autor:
Andrej Jančařík, Rana Rais, Lenka Monincová, Ranjeet Prasad Dash, Sarah C. Zimmermann, Barbara S. Slusher, Gregory J. Riggins, Jan Vávra, Pavel Majer, Alexandra J. Gadiano, Ying Wu, Lukáš Tenora, C. Ethan Slusher, Tomáš Tichý, Eva Prchalova
Publikováno v:
Journal of medicinal chemistry. 61(9)
Mebendazole (MBZ) was developed as a broad-spectrum anthelmintic but has recently shown efficacy as an anticancer agent. The use of MBZ for cancer, however, is challenging due to its poor solubility leading to poor bioavailability. Herein, we develop