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Autor:
Alexandra J, Willis, Radek, Indra, Laura E, Wohak, Osman, Sozeri, Kerstin, Feser, Iveta, Mrizova, David H, Phillips, Marie, Stiborova, Volker M, Arlt
Publikováno v:
Toxicology
Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. The effect of different p53-activating chemotherapeutic drugs on CYP1A1 expression, and the resultant effect on BaP m