Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexandra Indeglia"'
Autor:
Jonuelle Acosta, Qinglan Li, Nelson F. Freeburg, Nivitha Murali, Alexandra Indeglia, Grant P. Grothusen, Michelle Cicchini, Hung Mai, Amy C. Gladstein, Keren M. Adler, Katherine R. Doerig, Jinyang Li, Miguel Ruiz-Torres, Kimberly L. Manning, Ben Z. Stanger, Luca Busino, Maureen Murphy, Liling Wan, David M. Feldser
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ~90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this context is unknown. Here, using a m
Externí odkaz:
https://doaj.org/article/ff845a6444d4462dbb8f4fdf61c394b3
Autor:
Alexandra Indeglia, Jessica C. Leung, Sven A. Miller, Julia I-Ju Leu, James F. Dougherty, Nicole L. Clarke, Nicole A. Kirven, Chunlei Shao, Lei Ke, Scott Lovell, Thibaut Barnoud, David Y. Lu, Cindy Lin, Toshitha Kannan, Kevin P. Battaile, Tyler Hong Loong. Yang, Isabela Batista Oliva, Daniel T. Claiborne, Peter Vogel, Lijun Liu, Qin Liu, Yulia Nefedova, Joel Cassel, Noam Auslander, Andrew V. Kossenkov, John Karanicolas, Maureen E. Murphy
Publikováno v:
Cancer Discovery.
TP53 is the most frequently mutated gene in cancer, yet key target genes for p53-mediated tumor suppression remain unidentified. Here, we characterize a rare, African-specific, germline variant of TP53 in the DNA binding domain, Tyr107His (Y107H). NM
Autor:
Maureen E. Murphy, Donna L. George, Joseph M. Salvino, Dmitry I. Gabrilovich, David W. Speicher, Qin Liu, Andrew V. Kossenkov, Joel Cassel, Hsin-Yao Tang, Rebecca Moeller, Emilio Sanseviero, Keerthana Gnanapradeepan, Madeline Good, Tetyana Martynyuk, Alexandra Indeglia, Joshua L.D. Parris, Adi Narayana Reddy Poli, Subhasree Basu, Julia I-Ju Leu, Jessica C. Leung, Thibaut Barnoud
The protein chaperone HSP70 is overexpressed in many cancers including colorectal cancer, where overexpression is associated with poor survival. We report here the creation of a uniquely acting HSP70 inhibitor (HSP70i) that targets multiple compartme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073b2f42516291eb9829006b455b46e4
https://doi.org/10.1158/0008-5472.c.6512206.v1
https://doi.org/10.1158/0008-5472.c.6512206.v1
Autor:
Maureen E. Murphy, Donna L. George, Joseph M. Salvino, Dmitry I. Gabrilovich, David W. Speicher, Qin Liu, Andrew V. Kossenkov, Joel Cassel, Hsin-Yao Tang, Rebecca Moeller, Emilio Sanseviero, Keerthana Gnanapradeepan, Madeline Good, Tetyana Martynyuk, Alexandra Indeglia, Joshua L.D. Parris, Adi Narayana Reddy Poli, Subhasree Basu, Julia I-Ju Leu, Jessica C. Leung, Thibaut Barnoud
Supp Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca1e074aefff7268fc2dd6710e27ac5
https://doi.org/10.1158/0008-5472.22426009
https://doi.org/10.1158/0008-5472.22426009
Autor:
Maureen E. Murphy, Donna L. George, Joseph M. Salvino, Dmitry I. Gabrilovich, David W. Speicher, Qin Liu, Andrew V. Kossenkov, Joel Cassel, Hsin-Yao Tang, Rebecca Moeller, Emilio Sanseviero, Keerthana Gnanapradeepan, Madeline Good, Tetyana Martynyuk, Alexandra Indeglia, Joshua L.D. Parris, Adi Narayana Reddy Poli, Subhasree Basu, Julia I-Ju Leu, Jessica C. Leung, Thibaut Barnoud
Supplemental figures file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c207b4edfe0cb00060fb73585f765385
https://doi.org/10.1158/0008-5472.22426006
https://doi.org/10.1158/0008-5472.22426006
Autor:
Jessica C. Leung, Julia I-Ju Leu, Alexandra Indeglia, Toshitha Kannan, Nicole L. Clarke, Nicole A. Kirven, Harsh Dweep, David Garlick, Thibaut Barnoud, Andrew V. Kossenkov, Donna L. George, Maureen E. Murphy
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Missense mutations that inactivate p53 occur commonly in cancer, and germline mutations in TP53 cause Li Fraumeni syndrome, which is associated with early-onset cancer. In addition, there are over two hundred germline missense variants of p53 that re
Publikováno v:
Oncogene
The TP53 gene continues to hold distinction as the most frequently mutated gene in cancer. Since its discovery in 1979, hundreds of research groups have devoted their efforts toward understanding why this gene is so frequently selected against by tum
Autor:
Maureen Murphy, Jessica Leung, Julia Leu, Alexandra Indeglia, Nicole Clarke, Toshitha Kannan, Nicole Kirven, Thibaut Barnoud, Andrew Kossenkov, Donna L. George
Publikováno v:
The FASEB Journal. 36
Autor:
Renyta Moses, Gregory Kelly, Alexandra Indeglia, Sven Miller, John Karanicolas, Maureen Murphy, Kara Maxwell
Publikováno v:
Cancer Research. 83:2608-2608
The gene Tp53 encodes for the protein p53 which has many tumor suppressive functions. Li-Fraumeni syndrome is characterized by germline Tp53 mutations that significantly increase the risk of cancer. The p53 amino acid residue arginine 181 is one such
Autor:
Joel Cassel, Jessica C. Leung, Subhasree Basu, Hsin-Yao Tang, David W. Speicher, Rebecca A. Moeller, Adi Narayana Reddy Poli, Donna L. George, Keerthana Gnanapradeepan, Andrew V. Kossenkov, Dmitry I. Gabrilovich, Julia I-Ju Leu, Joshua L.D. Parris, Tetyana Martynyuk, Emilio Sanseviero, Qin Liu, Alexandra Indeglia, Joseph M. Salvino, Madeline Good, Maureen E. Murphy, Thibaut Barnoud
Publikováno v:
Cancer Res
The protein chaperone HSP70 is overexpressed in many cancers including colorectal cancer, where overexpression is associated with poor survival. We report here the creation of a uniquely acting HSP70 inhibitor (HSP70i) that targets multiple compartme