Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alexandra Hockla"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of protein
Externí odkaz:
https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a
Autor:
Jyotica Batra, Jessica Robinson, Christine Mehner, Alexandra Hockla, Erin Miller, Derek C Radisky, Evette S Radisky
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50028 (2012)
Excess proteolytic activity of matrix metalloproteinases (MMPs) contributes to the development of arthritis, cardiovascular diseases and cancer progression, implicating these enzymes as therapeutic targets. While many small molecule inhibitors of MMP
Externí odkaz:
https://doaj.org/article/3c3cbb103e984d14a89493ad8be73394
Supplementary Figure 1 from PRSS3/Mesotrypsin Is a Therapeutic Target for Metastatic Prostate Cancer
Autor:
Evette S. Radisky, Derek C. Radisky, John A. Copland, Moh'd A. Salameh, Erin Miller, Alexandra Hockla
PDF file - 226K, Figure demonstrating that silencing of PRSS3 in prostate cancer cells significantly reduced migration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c504ab6e97ce93979460f76326a3e04
https://doi.org/10.1158/1541-7786.22517250
https://doi.org/10.1158/1541-7786.22517250
Publikováno v:
Journal of Molecular Biology. 435:168095
Matrix metalloproteinases (MMPs) are key drivers of various diseases, including cancer. While several antibodies against MMPs are in development, our goal is to construct therapeutic anti-MMP inhibitors based on a natural broad MMP inhibitor, tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a077062fa7d71b9895de1cf099f38d3f
https://doi.org/10.1101/2022.12.29.522231
https://doi.org/10.1101/2022.12.29.522231
Autor:
Erin Miller, Mathew A. Coban, S. John Weroha, Derek C. Radisky, Christine Mehner, Alexandra Hockla, Evette S. Radisky
Publikováno v:
Oncogene
A major clinical challenge of ovarian cancer is the development of malignant ascites accompanied by widespread peritoneal metastasis. In ovarian clear cell carcinoma (OCCC), a challenging subtype of ovarian cancer, this problem is compounded by near-
Autor:
Christine Mehner, Alexandra Hockla, Mathew Coban, Benjamin Madden, Rosendo Estrada, Derek C. Radisky, Evette S. Radisky
Publikováno v:
The Journal of biological chemistry. 298(8)
Ovarian clear cell carcinoma (OCCC) is an understudied poor prognosis subtype of ovarian cancer lacking in effective targeted therapies. Efforts to define molecular drivers of OCCC malignancy may lead to new therapeutic targets and approaches. Among
Autor:
Anat Shahar, Itay Cohen, Alexandra Hockla, Shiran Lacham, Niv Papo, Matt Coban, Banumathi Sankaran, Thomas R. Caulfield, Evette S. Radisky
Publikováno v:
The Journal of biological chemistry, vol 294, iss 13
Serine protease inhibitors of the Kunitz-bovine pancreatic trypsin inhibitor (BPTI) family are ubiquitous biological regulators of proteolysis. These small proteins are resistant to proteolysis, but can be slowly cleaved within the protease-binding l