Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexandra Hinniger"'
Autor:
Melusine Bleu, Fanny Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Marianne Bachmann Salvy, Rui Lopes, Inês Amorim Monteiro Barbosa, Cecile Delmas, Alexandra Hinniger, Suzanne Chau, Markus Kaufmann, Simon Haenni, Karolin Berneiser, Maria Wahle, Ivana Moravec, Alexandra Vissières, Tania Poetsch, Erik Ahrné, Nathalie Carte, Johannes Voshol, Elisabeth Bechter, Jacques Hamon, Marco Meyerhofer, Dirk Erdmann, Matteo Fischer, Therese Stachyra, Felix Freuler, Sascha Gutmann, César Fernández, Tobias Schmelzle, Ulrike Naumann, Guglielmo Roma, Kate Lawrenson, Cristina Nieto-Oberhuber, Amanda Cobos-Correa, Stephane Ferretti, Dirk Schübeler, Giorgio Giacomo Galli
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extrace
Externí odkaz:
https://doaj.org/article/e459f346777c48fab385e6b2235f6c4c
Autor:
Andreas Boettcher, Alexandra Hinniger, Christopher J. Farady, Sandra Kapps-Fouthier, Nicola Hughes, Henri Mattes, Carien Dekker, Jörg Eder, Angela Mackay, Nikolaus Stiefl, Michael Wright, P. Erbel
Publikováno v:
Journal of molecular biology. 433(24)
The NLRP3 inflammasome assembles in response to a variety of pathogenic and sterile danger signals, resulting in the production of interleukin-1β and interleukin-18. NLRP3 is a key component of the innate immune system and has been implicated as a d
Autor:
Johannes Voshol, Therese Stachyra, Alexandra Vissieres, Elisabeth Bechter, Verena Apfel, Erik Ahrné, Maria Wahle, Suzanne Chau, Ivana Moravec, Karolin Fiona Berneiser, Nathalie Carte, Tania Poetsch, Rui Lopes, Dirk Schübeler, Simon Haenni, Markus Kaufmann, Stephane Ferretti, Dirk Erdmann, Alexandra Hinniger, Marianne Bachmann Salvy, Jacques Hamon, Guglielmo Roma, Amanda Cobos-Correa, Ulrike Naumann, César Fernández, Louise Barys, Cristina Nieto-Oberhuber, Giorgio G. Galli, Melusine Bleu, Matteo Fischer, Felix Freuler, Sascha Gutmann, Kate Lawrenson, Fanny Mermet-Meillon, Tobias Schmelzle, Cecile Delmas, Laura Holzer, Marco Meyerhofer, Ines Barbosa
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The transcription factor PAX8 is critical for the development of the thyroid and urogenital system. Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian cancers. While a plethora of PAX8-regula
Autor:
Enrico G. Funhoff, Daniela Angst, Philipp Janser, Anna Vulpetti, Alexandra Hinniger, Robert Alexander Pulz, Sascha Gutmann, Bruno Cenni, Amanda Littlewood-Evans, François Gessier, Clemens Scheufler, Janet Dawson, Rudolf Wälchli, Grazyna Wieczorek, Alfred Zimmerlin, Christian Beerli, Barbara Nuesslein-Hildesheim
Publikováno v:
Journal of medicinal chemistry. 63(10)
Bruton's tyrosine kinase (BTK), a cytoplasmic tyrosine kinase, plays a central role in immunity and is considered an attractive target for treating autoimmune diseases. The use of currently marketed covalent BTK inhibitors is limited to oncology indi
Autor:
Nina Ripin, Julien Boudet, Malgorzata M. Duszczyk, Alexandra Hinniger, Michael Faller, Miroslav Krepl, Abhilash Gadi, Robert J. Schneider, Jiří Šponer, Nicole C. Meisner-Kober, Frédéric H.-T. Allain
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116 (8)
Proceedings of the National Academy of Sciences of the United States of America, 116 (8)
Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3′ untranslated regions, targeting these mRNAs for rapid degradation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7720f9e294b2ac4d90e555d58b530bd3
Autor:
Silvio Roggo, Cecile Delmas, Nathalie Bürstner, Matthias Rottmann, Jason Murphy, Manuel Mihalic, Jutta Blank, Dominik Pistorius, Nils Ostermann, Dominic Hoepfner, Alexandra Hinniger, Brigitta Liechty, Esther K. Schmitt, Markus Schirle, Jason R. Thomas, Felix Freuler, Bernd Gerhartz
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(17)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a screen for antiplasmodial compounds by using a natu
Autor:
Niko Schmiedeberg, Gabriele Fendrich, Ralf Glatthar, Henrik Möbitz, André Strauss, Sascha Gutmann, Silvio Ofner, Peter Drückes, Sylvie Antz, Aleksandar Stojanovic, Helmut Sparrer, S. Rieffel, Henri Mattes, Alexandra Hinniger, Troxler Thomas J
Publikováno v:
The Journal of biological chemistry. 290(24)
Macrophages are important cellular effectors in innate immune responses and play a major role in autoimmune diseases such as rheumatoid arthritis. Cancer Osaka thyroid (COT) kinase, also known as mitogen-activated protein kinase kinase kinase 8 (MAP3
Autor:
Jason R. Thomas, Silvio Roggo, Jutta Blank, Felix Freuler, Manuel Mihalic, Markus Schirle, Cecile Delmas, Nathalie Bürstner, Jason Murphy, Dominic Hoepfner, Dominik Pistorius, Alexandra Hinniger, Brigitta Liechty, Esther K. Schmitt, Bernd Gerhartz, Nils Ostermann, Matthias Rottmann
Publikováno v:
ChemBioChem. 16:2406-2406
Autor:
Wolfgang Jahnke, Alexandra Hinniger, César Fernández, Alvar D. Gossert, Sascha Gutmann, André Strauss
Publikováno v:
Journal of biomolecular NMR. 51(4)
An easy to use and robust approach for amino acid type selective isotope labeling in insect cells is presented. It relies on inexpensive commercial media and can be implemented in laboratories without sophisticated infrastructure. In contrast to prev