Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alexandra Hicks"'
Autor:
Samuel Lessard, Pauline Rimmelé, Hui Ling, Kevin Moran, Benjamin Vieira, Yi-Dong Lin, Gaurav Manohar Rajani, Vu Hong, Andreas Reik, Richard Boismenu, Ben Hsu, Michael Chen, Bettina M. Cockroft, Naoya Uchida, John Tisdale, Asif Alavi, Lakshmanan Krishnamurti, Mehrdad Abedi, Isobelle Galeon, David Reiner, Lin Wang, Anne Ramezi, Pablo Rendo, Mark C. Walters, Dana Levasseur, Robert Peters, Timothy Harris, Alexandra Hicks
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract BIVV003 is a gene-edited autologous cell therapy in clinical development for the potential treatment of sickle cell disease (SCD). Hematopoietic stem cells (HSC) are genetically modified with mRNA encoding zinc finger nucleases (ZFN) that ta
Externí odkaz:
https://doaj.org/article/eeb0c50036ba4eed80ba42d7f6cae1af
Autor:
Claus Bachert, Alexandra Hicks, Simon Gane, Anju T. Peters, Philippe Gevaert, Scott Nash, Julie E. Horowitz, Harry Sacks, Juby A. Jacob-Nara
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chronic rhinosinusitis with nasal polyps (CRSwNP) is predominantly a type 2 inflammatory disease associated with type 2 (T2) cell responses and epithelial barrier, mucociliary, and olfactory dysfunction. The inflammatory cytokines interleukin (IL)-4,
Externí odkaz:
https://doaj.org/article/07680387bb2f4661b246cb0f136e66af
Autor:
Hongwei Han, Sheila Cummings, Kai-Ting C. Shade, Jennifer Johnson, George Qian, Joseph Gans, Srinivas Shankara, Javier Escobedo, Erik Zarazinski, Renee Bodinizzo, Dinesh Bangari, Paul Bryce, Alexandra Hicks
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Ocular surface diseases, including conjunctivitis, are recognized as common comorbidities in atopic dermatitis (AD) and occur at an increased frequency in patients with AD treated with biologics targeting IL-4 receptor α (IL-4Rα) or IL-13. However,
Externí odkaz:
https://doaj.org/article/39c1aafcc7e24ff0baf544fbefe43bba
Autor:
Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180870 (2017)
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune
Externí odkaz:
https://doaj.org/article/a511e5553a1e4c19982a055d21745012
Autor:
Peter J Stivers, Lauren Harmonay, Alexandra Hicks, Huseyin Mehmet, Melody Morris, Gain M Robinson, Peter R Strack, Mary J Savage, Dennis M Zaller, Izabela Zwierzynski, Philip E Brandish
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145151 (2015)
Glucocorticoid signaling regulates target genes by multiple mechanisms, including the repression of transcriptional activities of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) though direct protein-protein interactions and subs
Externí odkaz:
https://doaj.org/article/38e20953737e4617ae4904e635032021
Autor:
Yannis Hara, Viktor T. Lemgart, Nis Halland, Kiana Mahdaviani, Jean-Antoine Ribeil, Samuel Lessard, Alexandra Hicks, David R. Light
Publikováno v:
Blood Advances. 7:2317-2323
Autor:
Rayudu Gopalakrishna, Charlotte Y. Lin, Andrew Oh, Calvin Le, Seolyn Yang, Alexandra Hicks, Mark S. Kindy, William J. Mack, Narayan R. Bhat
Publikováno v:
FEBS Letters. 596:2914-2927
Autor:
Yannis Hara, Emily Kawabata, Viktor T. Lemgart, Paola G. Bronson, Alexandra Hicks, Robert Peters, Sriram Krishnamoorthy, Jean-Antoine Ribeil, Lisa J. Schmunk, Jennifer Eglinton, Nicholas A. Watkins, David J. Roberts, Emanuele Di Angelantonio, John Danesh, William J. Astle, Dirk S. Paul, Samuel Lessard, Adam S. Butterworth
Sickle cell disease (SCD) remains a major health burden with limited treatment options. Despite promising gene-editing clinical trials, there is an unmet need for cost-effective therapies. As induction of fetal hemoglobin (HbF) is an established ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f4c9d9c955b0ba3db33b5cf1ae487d8
https://doi.org/10.1101/2023.03.14.23287244
https://doi.org/10.1101/2023.03.14.23287244
Autor:
Yannis Hara, Emily Kawabata, Viktor T. Lemgart, Paola G. Bronson, Alexandra Hicks, Sriram Krishnamoorthy, Nicholas Watkins, Robert Peters, David J. Roberts, Emanuele Di Angelantonio, John Danesh, William Astle, Dirk S. Paul, Samuel Lessard, Adam S. Butterworth
Publikováno v:
Blood. 140:952-953