Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Alexandra Haase"'
Autor:
Kevin Ullmann, Felix Manstein, Wiebke Triebert, Nils Kriedemann, Annika Franke, Jana Teske, Mira Mertens, Victoria Lupanow, Gudrun Göhring, Alexandra Haase, Ulrich Martin, Robert Zweigerdt
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Background Human pluripotent stem cells (hPSCs) have an enormous therapeutic potential, but large quantities of cells will need to be supplied by reliable, economically viable production processes. The suspension culture (three-dimensional;
Externí odkaz:
https://doaj.org/article/68aa172d3c3c41398fe5f1d1b2655b03
Autor:
Chaohui Lin, Edmund Osei Kuffour, Nina V. Fuchs, Christoph G.W. Gertzen, Jesko Kaiser, Maximilian Hirschenberger, Xiao Tang, Haifeng C. Xu, Oliver Michel, Ronny Tao, Alexandra Haase, Ulrich Martin, Thomas Kurz, Ingo Drexler, Boris Görg, Philipp A. Lang, Tom Luedde, Konstantin M.J. Sparrer, Holger Gohlke, Renate König, Carsten Münk
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113277- (2023)
Summary: Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal transduction and regulation of this cascade is achieved by post-translat
Externí odkaz:
https://doaj.org/article/a3e194c999a94c19ad46494fc14d84d4
Autor:
Hannah Heseding, Kirsten Jahn, Björn Brändl, Alexandra Haase, Ian O. Shum, Tim Kohrn, Stefan Bleich, Helge Frieling, Ulrich Martin, Franz-Josef Müller, Stephanie Wunderlich, Maximilian Deest
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103143- (2023)
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by loss of paternal expression of imprinted genes on chromosome 15q11-q13. We established a human induced pluripotent stem cell line (hiPSC), ZIPi021-A, from fibroblasts of a 4-year-
Externí odkaz:
https://doaj.org/article/3af5809a4a3547f581464dae471edb82
Autor:
Sylvia Merkert, Alexandra Haase, Julia Dahlmann, Gudrun Göhring, Fakhar H. Waqas, Frank Pessler, Ulrich Martin, Ruth Olmer
Publikováno v:
Stem Cell Research, Vol 69, Iss , Pp 103090- (2023)
The nuclear factor erythroid 2-related factor 2 (NFE2L2, known as NRF2) regulates the expression of antioxidative and anti-inflammatory proteins. In order to investigate its impact during viral infections and testing of antiviral compounds, we applie
Externí odkaz:
https://doaj.org/article/8e6814b4fbde47d2b87e5fb062e24452
Autor:
Reto Eggenschwiler, Thomas Gschwendtberger, Christian Felski, Christopher Jahn, Florian Langer, Jared Sterneckert, Andreas Hermann, Jonathan Lühmann, Doris Steinemann, Alexandra Haase, Ulrich Martin, Susanne Petri, Tobias Cantz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract CRISPR prime-editors are emergent tools for genome editing and offer a versatile alternative approach to HDR-based genome engineering or DNA base-editors. However, sufficient prime-editor expression levels and availability of optimized trans
Externí odkaz:
https://doaj.org/article/0135844e7f1c4db4843fcf46ee926ef6
Autor:
Felix Manstein, Kevin Ullmann, Christina Kropp, Caroline Halloin, Wiebke Triebert, Annika Franke, Clara‐Milena Farr, Anais Sahabian, Alexandra Haase, Yannik Breitkreuz, Michael Peitz, Oliver Brüstle, Stefan Kalies, Ulrich Martin, Ruth Olmer, Robert Zweigerdt
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 1063-1080 (2021)
Abstract To harness the full potential of human pluripotent stem cells (hPSCs) we combined instrumented stirred tank bioreactor (STBR) technology with the power of in silico process modeling to overcome substantial, hPSC‐specific hurdles toward the
Externí odkaz:
https://doaj.org/article/c7121fae9196446f87e88d0aaf778d3a
Autor:
Maria Elena Ricci Signorini, Monika Szepes, Anna Melchert, Mine Bakar, Sylvia Merkert, Alexandra Haase, Gudrun Göhring, Ulrich Martin, Ina Gruh
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102697- (2022)
Calcium plays a key role in cardiomyocytes (CMs) for the translation of the electrical impulse of an action potential into contraction forces. A rapid, not-invasive fluorescence imaging technology allows for the monitoring of calcium transients in hu
Externí odkaz:
https://doaj.org/article/523c01723dc14a74ba038e208cc2b18d
Autor:
Abdulai Usman, Alexandra Haase, Sylvia Merkert, Gudrun Göhring, Georg Hansmann, Henning Gall, Ralph Schermuly, Ulrich Martin, Ruth Olmer
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102488- (2021)
Loss-of-function mutations in the bone morphogenetic protein receptor 2 (BMPR2) gene are common in heritable or idiopathic pulmonary arterial hypertension (PAH), and can result in functional impairment of both endothelial and vascular smooth muscle c
Externí odkaz:
https://doaj.org/article/b9d99ba811ea4e87824f6f41e41cd4f8
Autor:
Alexandra Haase, Tim Kohrn, Veronika Fricke, Maria Elena Ricci Signorini, Merlin Witte, Gudrun Göhring, Ina Gruh, Ulrich Martin
Publikováno v:
Stem Cell Research, Vol 52, Iss , Pp 102206- (2021)
Transgenic hiPSC lines carrying reporter genes represent valuable tools for functional characterization of iPSC derivatives, disease modelling and clinical evaluation of cell therapies. Here, the hiPSC line ‘Phoenix’ (Haase et al., 2017) was gene
Externí odkaz:
https://doaj.org/article/52dd4a2589b041949e6c518afe5ad4b6
Autor:
Elisabeth Stelling, Melanie Ricke-Hoch, Sergej Erschow, Steve Hoffmann, Anke Katharina Bergmann, Maren Heimerl, Stefan Pietzsch, Karin Battmer, Alexandra Haase, Britta Stapel, Michaela Scherr, Jean-Luc Balligand, Ofer Binah, Denise Hilfiker-Kleiner
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3000739 (2020)
Cardiac levels of the signal transducer and activator of transcription factor-3 (STAT3) decline with age, and male but not female mice with a cardiomyocyte-specific STAT3 deficiency conditional knockout (CKO) display premature age-related heart failu
Externí odkaz:
https://doaj.org/article/865e8d203dec44ada45be7c08db29fb5