Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alexandra H. Nirschl"'
Autor:
Pancras C. Wong, Ruth R. Wexler, Xiaojun Zhang, Joseph M. Luettgen, Alan R. Rendina, Anzhi Wei, Swanee Jacutin-Porte, Robert M. Knabb, Jiang Wen, Gang Luo, Timothy M. Harper, Xuhong Cheng, Peter W. Glunz, Yan Zou, Rushith Kumar Anumula, E. Scott Priestley, Daniel L. Cheney, Alexandra H. Nirschl, Nicholas R. Wurtz
Publikováno v:
ACS Medicinal Chemistry Letters. 5:188-192
Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine
Autor:
Mark R. Harpel, Carolyn A. Weigelt, Pancras C. Wong, Rushith Kumar Anumula, Xuhong Cheng, Anzhi Wei, Xiaojun Zhang, Alan R. Rendina, Delucca Indawati, Guanglin Luo, Ruth R. Wexler, Peter W. Glunz, Robert M. Knabb, Eldon Scott Priestley, Yan Zou, Joseph M. Luettgen, Alexandra H. Nirschl, Daniel L. Cheney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5244-5248
Aminoisoquinoline and isoquinoline groups have successfully replaced the more basic P1 benzamidine group of an acylsulfonamide factor VIIa inhibitor. Inhibitory activity was optimized by the identification of additional hydrophobic and hydrophilic P
Autor:
Luciano Mueller, Dietmar A. Seiffert, Ruth R. Wexler, Anzhi Wei, John A. Newitt, Jeffrey M. Bozarth, Alexandra H. Nirschl, Paul E. Morin, Xiao Wen, Daniel L. Cheney, James K. Tamura, Alan R. Rendina, William J. Metzler, Nicholas R. Wurtz, E. Scott Priestley
Publikováno v:
Journal of medicinal chemistry. 58(6)
A multidisciplinary, fragment-based screening approach involving protein ensemble docking and biochemical and NMR assays is described. This approach led to the discovery of several structurally diverse, neutral surrogates for cationic factor VIIa P1