Deficiency of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Intestinal Epithelial Cells Has No Appreciable Impact on Dextran Sulphate Sodium Colitis Severity But Promotes Wound Healing

Autor: Marianne R. Spalinger, Gerhard Rogler, Michael Scharl, Kirstin Atrott, Alexandra Gerstgrasser, Stephanie Kasper, Claudia Gottier, Tina Raselli, Isabelle Frey-Wagner, Anne Fischbeck-Terhalle, Irina Leonardi

Publikováno v: Digestion

Background/Aims: The protein tyrosine phosphatase non-receptor type 2 (PTPN2) is known to mediate susceptibility to inflammatory bowel diseases. Cell culture experiments suggest that PTPN2 influences barrier function, autophagy and secretion of pro-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb3c00e9367a984e49d97be7a96421e

Cell-specific Activation of the Nrf2 Antioxidant Pathway Increases Mucosal Inflammation in Acute but Not in Chronic Colitis

Autor: Alexandra Gerstgrasser, Isabelle Frey-Wagner, Kirstin Atrott, Hassan Melhem, Sabine Werner, Matthias Schäfer, Irina Leonardi, Gerhard Rogler

Publikováno v: Journal of Crohn's and Colitis, 11 (4)

Background and Aims The transcription factor Nrf2 is a major modulator of the cellular antioxidant response. Oxidative burst of infiltrating macrophages leads to a massive production of reactive oxygen species in inflamed tissue of inflammatory bowel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea4a62852147fd4fed9951f14afff8a

Contents Vol. 93, 2016

Autor: Kohei Oda, Koichi Kurahara, Felix Hahn, Johannes Betge, Eri Takeshita, Irina Leonardi, Soichiro Ishihara, Norma Quintanilla, Alexandra Gerstgrasser, Tianzuo Zhan, Thomas Hielscher, Kazushige Kawai, Toshiaki Tanaka, Tadahiko Fuchigami, Shimpei Shirai, Hidenori Matsui, Shuji Kanmura, Anthony P. Olive, Tomomichi Kiyomatsu, Yuichiro Tanaka, Kizhake V. Soman, Kensuke Otani, Shunichi Yanai, Kazuma Fujimoto, Claudia Gottier, Druckerei Stückle, Yoichiro Ito, Girish Hiremath, Gerhard Rogler, Takayuki Matsumoto, Motoyasu Kusano, Tamotsu Sugai, Masahiko Nakamura, Hiroki Taguchi, Takashi Ohyama, Hiroyoshi Endo, Koji Murono, Hiroaki Nozawa, Nanae Tsuruoka, Yuzo Nagai, Anders Øverby, Stephanie Kasper, Christina Nance, Matthias P. Ebert, Sinead M. Smith, Hiroyuki Kobayashi, Alexander Kurosky, Natsuko Sakata, Isabelle Frey-Wagner, Toshiaki Watanabe, Hirohatu Kawakubo, Colm O'Morain, Keisuke Kawasaki, Hitoshi Setoyama, Yumi Oshiro, Corinna Hauf, Tomomi Yoshioka, Christof Straub, Keiji Matsunaga, Michael Scharl, Kayo Akutagawa, Megumi Hara, Kalpesh Thakkar, Shotaro Nakamura, Hironori Yamaguchi, Carla M. Davis, Yuichiro Nasu, John E. Wiktorowicz, Koji Yasuda, Shiho Arima, Anne Fischbeck-Terhalle, Shinichi Hashimoto, Hitomi Hamamoto, Toshihiro Fujita, Somay Yamagata Murayama, Konrad Pazdrak, Yasuhisa Sakata, Akio Ido, Fumisato Sasaki, Tina Raselli, Ryuichi Iwakiri, Marianne R. Spalinger, Takeshi Nishikawa, Kirstin Atrott, Keisuke Hata, Yuko Morinaga, Sebastian Belle

Publikováno v: Digestion. 93

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8a7ce16535d1d95b4036371227349e6
https://doi.org/10.1159/000447504

Sa1786 Loss of PTPN2 in the Intestinal Epithelium of Mice Only Fractionally Affects Inflammation in DSS Colitis but Leads to Epithelial Transformations When Repeatedly Treated With DSS

Autor: Alexandra Gerstgrasser, Isabelle Frey-Wagner, Gerhard Rogler, Irina Leonardi, Kirstin Atrott, Michael Scharl, Stephanie Kasper, Marianne R. Spalinger, Michael Fried

Publikováno v: Gastroenterology. 148:S-331

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff0a7ac300611005a68e346a8b4a8a87
https://doi.org/10.1016/s0016-5085(15)31102-1