Mathematical modeling reveals differential effects of erythropoietin on proliferation and lineage commitment of human hematopoietic progenitors in early erythroid culture

Autor: Daniel Ward, Deborah Carter, Martin Homer, Lucia Marucci, Alexandra Gampel

Publikováno v: Haematologica, Vol 101, Iss 3 (2016)

Erythropoietin is essential for the production of mature erythroid cells, promoting both proliferation and survival. Whether erythropoietin and other cytokines can influence lineage commitment of hematopoietic stem and progenitor cells is of signific

Externí odkaz: https://doaj.org/article/fb6066e70f964fea8b0453960c40d2aa

Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis

Autor: Emile van den Akker, Bethan R. Hawley, Stephanie Pellegrin, Ashley M. Toye, Paola Bianchi, Elisa Fermo, Timothy J. Satchwell, David J. Stephens, Annika Budnik, Alexandra Gampel, Wilma Barcellini, Kathryn E. Mordue

Publikováno v: Haematologica. 98:1788-1796

Congenital dyserythropoietic anemia type II is an autosomally recessive form of hereditary anemia caused by SEC23B gene mutations. Patients exhibit characteristic phenotypes including multinucleate erythroblasts, erythrocytes with hypoglycosylated me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc57195efa9eec2aa2f74deab596513a
https://doi.org/10.3324/haematol.2013.085522

Mathematical modeling reveals differential effects of erythropoietin on proliferation and lineage commitment of human hematopoietic progenitors in early erythroid culture

Autor: Alexandra Gampel, Martin Homer, Lucia Marucci, Deborah A. Carter, Daniel Ward

Publikováno v: Ward, D T, Carter, D A, Homer, M E, Marucci, L & Gampel, A 2016, ' Mathematical modelling reveals differential effects of erythropoietin on proliferation and lineage commitment of human hematopoietic progenitors in early erythroid culture ', Haematologica, vol. 101, no. 3, pp. 286-296 . https://doi.org/10.3324/haematol.2015.133637

Erythropoietin is essential for the production of mature erythroid cells, promoting both proliferation and survival. Whether erythropoietin and other cytokines can influence lineage commitment of hematopoietic stem and progenitor cells is of signific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58c72311191279eebb67ac8e3e82f63
https://pubmed.ncbi.nlm.nih.gov/26589912

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase

Autor: Matthew Wherlock, Alexandra Gampel, Clare E. Futter, Harry Mellor

Publikováno v: Journal of Cell Science. 117:3221-3231

The Rho family of small GTPases play a pivotal role in the dynamic regulation of the actin cytoskeleton. Recent studies have suggested that these signalling proteins also have wide-ranging functions in membrane trafficking pathways. The Rho family me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a9da937c2820cb10c6078fa536e47e
https://doi.org/10.1242/jcs.01193

Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1)

Autor: Harry Mellor, Richard M. Denton, Kate J. Heesom, Alexandra Gampel

Publikováno v: Current Biology. 11(17):1374-1379

A fundamental control point in the regulation of the initiation of protein synthesis is the formation of the eukaryotic initiation factor 4F (eIF-4F) complex. The formation of this complex depends upon the availability of the mRNA cap binding protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b88afe8db073f06f579fd41275c59b