Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexandra Galland"'
Publikováno v:
Therapeutic innovationregulatory science. 52(3)
Although regulatory guidance defines which preclinical data are required in general before proceeding to first-in-human clinical trials, a certain level of flexibility exists in the actual planning, timing, and design of a drug development program. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a090e914d60c7c1250d535e119f9310a
https://pubmed.ncbi.nlm.nih.gov/29714531
https://pubmed.ncbi.nlm.nih.gov/29714531
Autor:
Pierre-Alain Carrupt, Sophie Martel, Serge Rudaz, Yveline Henchoz, Davy Guillarme, Jean-Luc Veuthey, Alexandra Galland
Publikováno v:
Molecular Drug Properties-Measurement and Prediction
Molecular drug properties: measurement and prediction pp. 331-355
Molecular drug properties: measurement and prediction pp. 331-355
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faaf964cfd445a1d512ba4c50b17a76
https://doi.org/10.1002/9783527621286.ch13
https://doi.org/10.1002/9783527621286.ch13
Publikováno v:
Journal of Separation Science, Vol. 28, No 17 (2005) pp. 2374-80
CZE allows to measure the acidic dissociation constant (pKa) of many drug substances. However, determining the EOF intensity may be time-consuming, especially at a low pH. In order to overcome this drawback, a dynamic coating procedure of the capilla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b34a021be160f7a9954d3fded0a0cb7
https://doi.org/10.1002/jssc.200500213
https://doi.org/10.1002/jssc.200500213
Autor:
Serge Rudaz, Bernard Testa, Jean-Luc Veuthey, Cinzia Stella, Alexandra Galland, Pierre-Alain Carrupt, Xiangli Liu
Publikováno v:
Journal of Separation Science, Vol. 28, No 17 (2005) pp. 2350-62
An RPLC was developed to rapidly determine lipophilicity of neutral and basic compounds using three base deactivated RPLC stationary phases particularly designed for the analysis of basic compounds, namely, Supelcosil ABZ(+)Plus, Discovery RP Amide C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97da61d2d37ab588587bdd8d74aa0807
https://doi.org/10.1002/jssc.200500104
https://doi.org/10.1002/jssc.200500104
Autor:
Rubin Gulaboski, Fritz Scholz, Géraldine Bouchard, Hubert H. Girault, Pierre-Alain Carrupt, Valentin Mirčeski, Alexandra Galland
Publikováno v:
Physical Chemistry Chemical Physics, Vol. 5, No 17 (2003) pp. 3748-3751
The anionic forms of 26 drugs and organic model compounds have been extensively explored in the n-octanol/ water system using voltammetry at three-phase electrodes. The objective of this study was to validate the ability of this electrochemical syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f7a960ba1c2a662cc8a194091a998d
https://doi.org/10.1039/b304113a
https://doi.org/10.1039/b304113a
Publikováno v:
Journal of Chromatography. A, Vol. 953, No 1-2 (2002) pp. 39-53
The objectives of this study were to establish guidelines for the proper measurement of capacity factors (log k(IAMw) on immobilized artificial membrane (IAM) stationary phases. In this context, some aspects related to the extrapolation of log(kIAMw)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c888a7fcbc0ac23d4f5ee70666a6a08e
https://doi.org/10.1016/s0021-9673(02)00119-x
https://doi.org/10.1016/s0021-9673(02)00119-x
Autor:
Alexandra Galland, Stéphane Lecleire, Moïse Coëffier, François Tron, David Vaudry, Roland Charlionet, Nicolas Deniel, Pierre Déchelotte, Sandrine Thébault
Publikováno v:
Proteomics. Clinical applications. 4(3)
Purpose: Glutamine (Gln) has protective, anti-inflammatory effects in animal models and humans. Antioxidant nutrients may exert synergistic effects on intestinal functions. Therefore, these combined nutrients may have a therapeutic potential during i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91897bc4a78416159772aa40595a2e29
https://pubmed.ncbi.nlm.nih.gov/21137053
https://pubmed.ncbi.nlm.nih.gov/21137053
Autor:
Christine Susan Perry, William N. Charman, Alexandra Galland, Richard John Prankerd, Agnes Taillardat-Bertschinger
Publikováno v:
Journal of pharmaceutical sciences. 92(11)
Recent studies in a conscious dog model demonstrated intestinal lymphatic transport to be a significant contributor to the bioavailability of the highly lipid‐soluble free‐base of halofantrine (Hf), and surprisingly, also the poorly lipid‐solub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27815534e5f9b480f25635c9ce27c8e
https://pubmed.ncbi.nlm.nih.gov/14603507
https://pubmed.ncbi.nlm.nih.gov/14603507
Autor:
Hubert H. Girault, Géraldine Bouchard, Alexandra Galland, Bernard Testa, Nathalie Müller, Pierre-Alain Carrupt, Xiangli Liu
Publikováno v:
Helvetica Chimica Acta, Vol. 86, No 11 (2003) pp. 3533-3547
The objective of this study was to unravel the structural properties responsible for the partitioning of solutes in o‐nitrophenyl octyl ether (o‐NPOE)/H2O, a new solvent system for the determination of the partition coefficients of ions. A set of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b5a2f0488485435f747fcee3e16c57
https://archive-ouverte.unige.ch/unige:10601
https://archive-ouverte.unige.ch/unige:10601
Autor:
Xiangli Liu, Géraldine Bouchard, Nathalie Müller, Alexandra Galland, Hubert Girault, Bernard Testa, Pierre-Alain Carrupt
Publikováno v:
Helvetica Chimica Acta; Nov2003, Vol. 86 Issue 11, p3533-3547, 15p