Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexandra Friese"'
Autor:
Alexandra Friese, Alex C. Faesen, Pim J. Huis in ‘t Veld, Josef Fischböck, Daniel Prumbaum, Arsen Petrovic, Stefan Raunser, Franz Herzog, Andrea Musacchio
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
SKAP and Astrin form a heterodimer that localizes to spindle microtubules and to mature microtubule-kinetochore attachments during mitosis. Here, the authors identify molecular requirements for the inter-subunit interaction of SKAP and Astrin and kin
Externí odkaz:
https://doaj.org/article/166e11b186344cc996360ea2d3c1a08b
Autor:
Elizabeth Yihui Ng, Lara Dötsch, Wanjin Hong, Mohammad Akbarzadeh, Sasikala Thavam, Hélène Adihou, CongBao Kang, Sarah Zinken, Sonja Sievers, Axel Pahl, Ajaybabu V. Pobbati, Hacer Karatas, Christine Nowak, Gernot Hahne, Herbert Waldmann, Stéphanie M. Guéret, Malte Metz, Alexandra Friese
Publikováno v:
Journal of Medicinal Chemistry
Transcriptional enhanced associate domain (TEAD) transcription factors together with coactivators and corepressors modulate the expression of genes that regulate fundamental processes, such as organogenesis and cell growth, and elevated TEAD activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d188b53d24ea4b5125d0031211b3c2
https://doi.org/10.1021/acs.jmedchem.0c01275
https://doi.org/10.1021/acs.jmedchem.0c01275
Publikováno v:
Angewandte Chemie. 132:5644-5650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6922f4a5d34a66827948ffd212f661c
https://doi.org/10.1002/ange.201913904
https://doi.org/10.1002/ange.201913904
Autor:
Jessica Wagner, Tabea Schneidewind, Alexandra Brause, Herbert Waldmann, Alexandra Friese, Srinivasa Rao Vidadala, Petra Janning, Shobhna Kapoor, Matthias Bischoff, Juhi Sardana, Slava Ziegler, Tim Förster
Publikováno v:
Angewandte Chemie International Edition. 58:13009-13013
Cell-based screening is a powerful approach to identify novel chemical modulators and biological components of relevant biological processes. The canonical Wnt pathway is essential for normal embryonic development and tissue homeostasis, and its dere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f37240f5410a4e1fb917fc2dab2532
https://doi.org/10.1002/anie.201905977
https://doi.org/10.1002/anie.201905977
Autor:
Ingrid R. Vetter, Dale Corkery, Luca Laraia, Nelli Erwin, Herbert Waldmann, Maja Köhn, Pablo Rios-Munoz, Roland Winter, Mridula Dwivedi, Walter Hofer, Lei Li, Yao-Wen Wu, Malte Metz, Beate Schölermann, Andreas Brockmeyer, Laura Klewer, Alexandra Friese, Petra Janning, Hacer Karatas, Georgios Konstantinidis, Slava Ziegler
Publikováno v:
Nature Chemical Biology
Laraia, L, Friese, A, Corkery, D P, Konstantinidis, G, Erwin, N, Hofer, W, Karatas, H, Klewer, L, Brockmeyer, A, Metz, M, Schölermann, B, Dwivedi, M, Li, L, Rios-Munoz, P, Köhn, M, Winter, R, Vetter, I R, Ziegler, S, Janning, P, Wu, Y W & Waldmann, H 2019, ' The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis ', Nature Chemical Biology, vol. 15, no. 7, pp. 710-720 . https://doi.org/10.1038/s41589-019-0307-5
Laraia, L, Friese, A, Corkery, D P, Konstantinidis, G, Erwin, N, Hofer, W, Karatas, H, Klewer, L, Brockmeyer, A, Metz, M, Schölermann, B, Dwivedi, M, Li, L, Rios-Munoz, P, Köhn, M, Winter, R, Vetter, I R, Ziegler, S, Janning, P, Wu, Y W & Waldmann, H 2019, ' The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis ', Nature Chemical Biology, vol. 15, no. 7, pp. 710-720 . https://doi.org/10.1038/s41589-019-0307-5
Autophagy mediates the degradation of damaged proteins, organelles and pathogens, and plays a key role in health and disease. Thus, the identification of new mechanisms involved in the regulation of autophagy is of major interest. In particular, litt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6765c89454ca57ec6764c54a0bf42a5
https://doi.org/10.1038/s41589-019-0307-5
https://doi.org/10.1038/s41589-019-0307-5
Autor:
Julian, Wilke, Tatsuro, Kawamura, Hao, Xu, Alexandra, Brause, Alexandra, Friese, Malte, Metz, Dirk, Schepmann, Bernhard, Wünsch, Antonia, Artacho-Cordón, Francisco R, Nieto, Nobumoto, Watanabe, Hiroyuki, Osada, Slava, Ziegler, Herbert, Waldmann
Publikováno v:
Cell chemical biology. 28(6)
Phenotypic screening for bioactive small molecules is typically combined with affinity-based chemical proteomics to uncover the respective molecular targets. However, such assays and the explored bioactivity are biased toward the monitored phenotype,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b81aca241df801c6c805c5921000eb8
https://pubmed.ncbi.nlm.nih.gov/33567254
https://pubmed.ncbi.nlm.nih.gov/33567254
Autor:
Alexandra Friesen, Yuriy Kalinovsky
Publikováno v:
Particles, Vol 6, Iss 4, Pp 876-885 (2023)
The applicability of the effective models to the description of baryons and the behaviour of ratios of strange baryons to pions is discussed. In the framework of the EPNJL model, the Bethe–Salpeter equation is used to find masses of baryons, which
Externí odkaz:
https://doaj.org/article/6d6546edafba43588a37786c1b4bea9c
Autor:
Francisco R. Nieto, Hiroyuki Osada, Nobumoto Watanabe, Herbert Waldmann, Bernhard Wünsch, Hao Xu, Antonia Artacho-Cordón, Alexandra Brause, Malte Metz, Slava Ziegler, Dirk Schepmann, Tatsuro Kawamura, Alexandra Friese, Julian Wilke
Publikováno v:
Cell Chemical Biology. 28:848-854.e5
Phenotypic screening for bioactive small molecules is typically combined with affinity-based chemical proteomics to uncover the respective molecular targets. However, such assays and the explored bioactivity are biased toward the monitored phenotype,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80233852a94f640e2a0df9f993669921
https://doi.org/10.1016/j.chembiol.2021.01.009
https://doi.org/10.1016/j.chembiol.2021.01.009
Publikováno v:
Angewandte Chemie (International Ed. in English)
The prenyl‐protein chaperone PDEδ modulates the localization of lipidated proteins in the cell, but current knowledge about its biological function is limited. Small‐molecule inhibitors that target the PDEδ prenyl‐binding site have proven inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41976b3ae8d277286c5d50ed45acda2a
https://pubmed.ncbi.nlm.nih.gov/31829492
https://pubmed.ncbi.nlm.nih.gov/31829492
Autor:
Andrei Ursu, Hans R. Schöler, Herbert Waldmann, Andreas Hochheimer, Jan M. Bruder, Alexandra Friese
Publikováno v:
Cell Chemical Biology
Recent advances in induced pluripotent stem cell technologies and phenotypic screening shape the future of bioactive small-molecule discovery. In this review we analyze the impact of small-molecule phenotypic screens on drug discovery as well as on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff325178a52883e924dd83c7be6b4e22
https://hdl.handle.net/21.11116/0000-0003-DCD8-221.11116/0000-0003-DCDA-0
https://hdl.handle.net/21.11116/0000-0003-DCD8-221.11116/0000-0003-DCDA-0
