One-Pot Synthesis of an Amphiphilic ABC Triblock Copolymer PEO-b-PEHOx-b-PEtOz and Its Self-Assembly into Nanoscopic Asymmetric Polymersomes

Autor: Jens Gaitzsch, Alexandra Fillion, Wolfgang Meier, Davy Daubian

Publikováno v: Macromolecules. 53:11040-11050

We report an efficient one-pot synthesis of a new biocompatible amphiphilic ABC triblock terpolymer: poly(ethylene oxide)- block -poly(2-(3-ethylheptyl)-2-oxazoline)- block -poly(2-ethyl-2-oxazoline) (PEO- b -PEHOx- b -PEtOz) using sequential microwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c22cff7b252cc91997072f3658fa15b
https://doi.org/10.1021/acs.macromol.0c02301

Acridine-O

Autor: Jaime, Franco Pinto, Alexandra, Fillion, Patricia, Duchambon, Sophie, Bombard, Anton, Granzhan

Publikováno v: European journal of medicinal chemistry. 227

O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8ccc9c0ac2bef3a73dc1e24406a6d5c
https://pubmed.ncbi.nlm.nih.gov/34731767

Acridine–O6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity

Autor: Jaime Franco Pinto, Anton Granzhan, Alexandra Fillion, Sophie Bombard, Patricia Duchambon

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2022, 227, pp.113909. ⟨10.1016/j.ejmech.2021.113909⟩

International audience; O6-Methylguanine-DNA-methyltransferase (MGMT) is a key DNA repair enzyme involved in chemoresistance to DNA-alkylating anti-cancer drugs such as Temozolomide (TMZ) through direct repair of drug-induced O6-methylguanine residue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd3224c5e6ff105d48b14bb33c0f814