Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Alexandra Faustino"'
1
Akademický článek
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
Autor: Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho, Thomas Arnesen
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-termina
Externí odkaz: https://doaj.org/article/d00c6a73922e4ae69223e5ddad630fd5
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3
Akademický článek
GNAQ and BRAF mutations show differential activation of the mTOR pathway in human transformed cells
Autor: Helena Pópulo, Sandra Tavares, Alexandra Faustino, Joana B. Nunes, José Manuel Lopes, Paula Soares
Publikováno v: PeerJ, Vol 1, p e104 (2013)
Somatic mutations in GNAQ gene were described as being the main oncogenic activation in uveal melanomas, whereas mutations in BRAF gene have been described as a key genetic alteration that contributes to skin melanoma development. We have previously
Externí odkaz: https://doaj.org/article/d5da14327fa44e96b654aaf38428c356
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4
Dissertation/ Thesis
Optimização de métodos de escolha de materiais com base no desempenho sustentável
Autor: Sousa, Filipa Alexandra Faustino de
Tese de mestrado integrado. Engenharia Civil. Faculdade de Engenharia. Universidade do Porto. 2010
Externí odkaz: http://hdl.handle.net/10216/59127
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5
All different but all equal?: the role of age on the relationship between hr practices and turnover intention and employee well
Autor: Silva, Sofia Alexandra Faustino da
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
In recent decades there has been a global aging phenomenon, resulting in a more age diverse workforce. This phenomenon represents a challenge for organizations, which have the need to attract and retain the best talents through Human Resource Managem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4edd71beb65f94149039410894c95d7a
https://hdl.handle.net/10071/20847
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6
Arl13b Regulates Breast Cancer Cell Migration and Invasion by Controlling Integrin-Mediated Signaling
Autor: Pedro Castanheira, Inês C. Ferreira, Cristina Casalou, Andreia Ferreira, Alexandra Faustino, Ana Félix, José S. Ramalho, Daniela Vaqueirinho, Teresa Barona, Jacinta Serpa, Duarte C. Barral, Fernanda Silva
Publikováno v: Cancers, Vol 11, Iss 10, p 1461 (2019)
Cancers
Volume 11
Issue 10
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Breast cancer is the first cause of cancer-related mortality among women worldwide, according to the most recent estimates. This mortality is mainly caused by the tumors&rsquo
ability to form metastases. Cancer cell migration and invasion are es
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282abe3881eead9746ee43324d104961
https://www.mdpi.com/2072-6694/11/10/1461
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7
Viver o dropout : perceção e impacto nos psicólogos clínicos
Autor: Correia, Sofia Alexandra Faustino
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Tese de mestrado, Psicologia (Secção de Psicologia Clínica e da Saúde, Núcleo de Psicoterapia Cognitiva-Comportamental e Integrativo), Universidade de Lisboa, Faculdade de Psicologia, 2018 Submitted by Biblioteca FPIE-ULisboa (bibliorul@fpie.uli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::6f9e6f5e06b7c8c86cf1f5f2747e60ce
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8
Arf proteins in cancer cell migration
Autor: Alexandra Faustino, Cristina Casalou, Duarte C. Barral
Publikováno v: Small GTPases
Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins regulate several aspects of membrane trafficking, such as vesicle budding, tethering and cytoskeleton organization. Arf family members, including Arf-like (Arl) pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9ad9a7d42280a0e96c843a2f5feb2d
https://pubmed.ncbi.nlm.nih.gov/27589148
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9
Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms
Autor: Alexandra Faustino, Rui Gonçalo Martinho, Cymon J. Cox, Petra Van Damme, Pedro Prudêncio, Om Singh Rathore
Publikováno v: SCIENTIFIC REPORTS
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). Prokaryotes have at least 3 NATs, whereas humans have six distinct but highly co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c579afca96c59cf3c1bb40a4b5a6bfd6
https://biblio.ugent.be/publication/7242704/file/7242743
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10
Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors
Autor: Valdemar Máximo, Ricardo Celestino, Alexandra Faustino, Jorge Lima, António Gouveia, Paula Soares, João Vinagre, José Manuel Lopes
Publikováno v: European Journal of Human Genetics. 21:503-510
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, disclosing somatic KIT, PDGFRA and BRAF mutations. Loss of function of succinate dehydrogenase (SDH) complex is an alternative molecular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f075795b11a173153d1f919608fda1
https://doi.org/10.1038/ejhg.2012.205
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