Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexandra F. Long"'
Publikováno v:
eLife, Vol 9 (2020)
The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to move chromosomes. Yet, how it does s
Externí odkaz:
https://doaj.org/article/090fc8e457e747d9bdb542afaac5f579
Autor:
FuiBoon Kai, Guanqing Ou, Richard W Tourdot, Connor Stashko, Guido Gaietta, Mark F Swift, Niels Volkmann, Alexandra F Long, Yulong Han, Hector H Huang, Jason J Northey, Andrew M Leidal, Virgile Viasnoff, David M Bryant, Wei Guo, Arun P Wiita, Ming Guo, Sophie Dumont, Dorit Hanein, Ravi Radhakrishnan, Valerie M Weaver
Publikováno v:
The EMBO Journal. 41
Patient-derived organoids and cellular spheroids recapitulate tissue physiology with remarkable fidelity. We investigated how engagement with a reconstituted basement membrane in three dimensions (3D) supports the polarized, stress resilient tissue p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8521c25b6a5f48ddd107629b61e2a968
https://doi.org/10.15252/embj.2021109205
https://doi.org/10.15252/embj.2021109205
Autor:
Alexandra F. Long, Tim Stearns
Publikováno v:
Dev Cell
Multiciliated cells (MCCs) are extremely highly-differentiated, presenting >100 cilia and basal bodies. Therefore, MCC fate is thought to be terminal and irreversible. We analyzed how MCCs are removed from the airway-like mucociliary Xenopus epidermi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d050430af6d185909b8313ea6239a9db
https://doi.org/10.1016/j.devcel.2021.02.003
https://doi.org/10.1016/j.devcel.2021.02.003
Autor:
Arun P. Wiita, Bryant Dm, Margaret Guo, Guanqing Ou, FuiBoon Kai, Wei Guo, Viasnoff, Sophie Dumont, Dorit Hanein, Ravi Radhakrishnan, Yisu Han, Alexandra F. Long, Hai Huang, Andrew M. Leidal, Valerie M. Weaver, Richard W. Tourdot, Niels Volkmann, Guido Gaietta, Mark F. Swift, Jason J. Northey, Connor Stashko
Primary tissue organoids and cell spheroids recapitulate tissue physiology with remarkable fidelity. We investigated how engagement with a three dimensional laminin-rich extracellular matrix supports the polarized, stress resilient spheroid phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa1e3be97f3b2adb21e8286ebf08cec3
https://doi.org/10.1101/2021.07.14.452329
https://doi.org/10.1101/2021.07.14.452329
Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure
Publikováno v:
The Journal of cell biology, vol 219, iss 8
The Journal of Cell Biology
The Journal of Cell Biology
To segregate chromosomes, the mammalian spindle must generate and respond to force. How it does so remains poorly understood. Pulling on the spindle using microneedles, Long et al. show that it can locally dissipate sustained force by regulating micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df81244ae5cc06c3495439f9f0612304
https://escholarship.org/uc/item/7cn0h90f
https://escholarship.org/uc/item/7cn0h90f
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to coordinate chromosome movement. Yet,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f635abf41d4f28fd2b9872bbfc6bd3
Publikováno v:
Curr Opin Cell Biol
The kinetochore drives chromosome segregation at cell division. It acts as a physical link between chromosomes and dynamic microtubules, and as a signaling hub detecting and processing microtubule attachments to control anaphase onset. The mammalian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9b7bd9f8dcb505bd829953dc08adc6
https://escholarship.org/uc/item/7qh9h0x8
https://escholarship.org/uc/item/7qh9h0x8
SummaryThe kinetochore links chromosomes to dynamic spindle microtubules and drives both chromosome congression and segregation. To do so, the kinetochore must hold on to depolymerizing and polymerizing microtubules. At metaphase, one sister kinetoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ae0e675dc6add4c3bb41a46a970689
https://doi.org/10.1101/105916
https://doi.org/10.1101/105916
Autor:
Sophie Dumont, Valerie M. Weaver, Wei Guo, Ravi Radhakrishnan, FuiBoon Kai, Guanqing Ou, Christopher S. Chen, Richard W. Tourdot, Alexandra F. Long
Publikováno v:
Cancer Research. 79:1028-1028
Tumor dormancy is a clinical phenomenon in which disseminated tumor cells remain asymptomatic and undetectable over a long period of time. Dormant cells are able to maintain quiescence in hostile microenvironments, escape frontline cancer therapies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6869b01b50124669d0ab752dd666167d
https://doi.org/10.1158/1538-7445.am2019-1028
https://doi.org/10.1158/1538-7445.am2019-1028