Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexandra E. Stacy"'
Publikováno v:
Antioxidants, Vol 10, Iss 11, p 1801 (2021)
Multi-drug resistance (MDR) is a leading cause of cancer-related death, and it continues to be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to play an essential role in not only cancer progression and metastasis,
Externí odkaz:
https://doaj.org/article/43e84d073fb342e788c5a920837cdce9
Autor:
Jane E. Carland, Alexandra E. Stacy, Andrea L. Schaffer, Richard O. Day, Jonathan Brett, Stephanie E. Reuter, Sophie L. Stocker
Dose-prediction software is recommended to enable area under the curve over 24 h (AUC(24))-guided dosing of the antibiotic vancomycin. However, uncertainty remains about how best to implement software in the clinic. We describe the activity, over 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d86f9dad6694ebbbc3f98777d47a19
https://hdl.handle.net/11541.2/33061
https://hdl.handle.net/11541.2/33061
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-39 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Cancer is currently the second leading cause of death globally and is expected to be responsible for approximately 9.6 million deaths in 2018. With an unprecedented understanding of the molecular pathways that drive the development and progression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9845b468c00658349d873931d712f0ab
http://link.springer.com/article/10.1186/s13046-019-1094-2
http://link.springer.com/article/10.1186/s13046-019-1094-2
Autor:
Sophie L. Stocker, Deborah Marriott, Cindy Lau, Maurizio Stefani, Ranita Kirubakaran, Alexandra E. Stacy, Darren M. Roberts, Jonathan Brett, Stephanie E. Reuter, Richard O. Day, Jane E. Carland, Andrea L Schaffer, Jennifer J. Yang, Catriona F.J. Shen
Publikováno v:
Clinical pharmacology and therapeutics. 109(1)
This study evaluated the ability of a pilot therapeutic drug monitoring (TDM) Advisory Service to facilitate vancomycin therapeutic target attainment within a real-world clinical setting. The Service provided area under the concentration-time curve (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0015907194c2d8e03e50e2c96db662e
https://pubmed.ncbi.nlm.nih.gov/33190285
https://pubmed.ncbi.nlm.nih.gov/33190285
Publikováno v:
Journal of Investigative Dermatology. 141:S193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ba8c49f976ebf126f6c7f4179c18d4
https://doi.org/10.1016/j.jid.2021.08.267
https://doi.org/10.1016/j.jid.2021.08.267
Autor:
Paul V. Bernhardt, Danuta S. Kalinowski, Alexandra E. Stacy, Des R. Richardson, Patric J. Jansson, Duraippandi Palanimuthu
Publikováno v:
Journal of Medicinal Chemistry. 59:8601-8620
Multidrug resistance (MDR) mediated by P-glycoprotein (Pgp) represents a significant impediment to successful cancer treatment. The compound, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), has been shown to induce greater cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf21e41fe6a154684dec92f2a489a4b
https://doi.org/10.1021/acs.jmedchem.6b01050
https://doi.org/10.1021/acs.jmedchem.6b01050
Autor:
Paul V. Bernhardt, Alexandra E. Stacy, Des R. Richardson, Duraippandi Palanimuthu, Danuta S. Kalinowski, Patric J. Jansson
Publikováno v:
Journal of Medicinal Chemistry. 59:4965-4984
As the di-2-pyridylketone thiosemicarbazone (DpT) and 2-acetylpyridine thiosemicarbazone (ApT) series show potent antitumor activity in vitro and in vivo, we synthesized their fluorescent zinc(II) complexes to assess their intracellular distribution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8abb0f80a3f696f6d55a47e4a1a78f7
https://doi.org/10.1021/acs.jmedchem.6b00238
https://doi.org/10.1021/acs.jmedchem.6b00238
Publikováno v:
Molecular Pharmacology. 84:655-669
The ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) is an important member of the ABC transporter superfamily, which has been suggested to be involved in multidrug resistance (MDR) in cancer. Its diverse range of substrates includes many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb237646d7c00689464a3e0c3b53d0f6
https://doi.org/10.1124/mol.113.088609
https://doi.org/10.1124/mol.113.088609
Autor:
Danae M. Sharp, Alexandra E. Stacy, Sanaz Maleki, Des R. Richardson, Nicole A. Seebacher, Sumit Sahni, Tetsuo Yamagishi, Elaine Gutierrez, Akanksha Arvind, Patric J. Jansson
Publikováno v:
The Journal of biological chemistry. 290(15)
Background: There is a critical need for chemotherapeutics that overcome multidrug resistance (MDR). Results: Dp44mT is transported into the lysosome by Pgp, causing lysosomal targeting of Dp44mT and resulting in enhanced cytotoxicity in vitro and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d3b809b03c43433fd0404a5c4146e2
https://pubmed.ncbi.nlm.nih.gov/25720491
https://pubmed.ncbi.nlm.nih.gov/25720491