Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexandra E. Rangel"'
Autor:
Alex M. Yoshikawa, Alexandra E. Rangel, Liwei Zheng, Leighton Wan, Linus A. Hein, Amani A. Hariri, Michael Eisenstein, H. Tom Soh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Aptamer-based molecular switches that undergo a binding-induced conformational change have proven valuable for a wide range of applications, such as imaging metabolites in cells, targeted drug delivery, and real-time detection of biomolecule
Externí odkaz:
https://doaj.org/article/12a12ea770d94b42aa45c6c7c04fcec2
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 9, Pp m1193-m1193 (2012)
In the title compound, [RuCl2(C4H4N2)4]·2CH2Cl2, the RuII atom occupies a position of 222 symmetry and the C atom of the solvent molecule occupies a site with twofold symmetry. The RuII atom has a slightly distorted octahedral geometry. The pyrazine
Externí odkaz:
https://doaj.org/article/35cae7bc494849c39b7994298cb7aca1
Autor:
Aurora Alvarez-Buylla, Maria Dolores Moya-Garzon, Alexandra E. Rangel, Elicio E. Tapia, Julia Tanzo, H. Tom Soh, Luis A. Coloma, Jonathan Z. Long, Lauren A. O’Connell
Alkaloids are important bioactive molecules throughout the natural world, and in many animals they serve as a source of chemical defense against predation. Dendrobatid poison frogs bioaccumulate alkaloids from their diet to make themselves toxic or u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df0be35fa2b597c0961078a5507ecab5
https://doi.org/10.1101/2022.11.22.517437
https://doi.org/10.1101/2022.11.22.517437
Autor:
Trevor A. Feagin, Alexandra E. Rangel, Jennifer M. Heemstra, Robert G. Lowery, Hector S. Argueta-Gonzalez, Aimee A. Sanford
Publikováno v:
Chemical Science
Aptamers are widely employed as recognition elements in small molecule biosensors due to their ability to recognize small molecule targets with high affinity and selectivity. Structure-switching aptamers are particularly promising for biosensing appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a173ad64494368cb3e53124ef43505b3
https://doi.org/10.26434/chemrxiv.14541216
https://doi.org/10.26434/chemrxiv.14541216
Autor:
Alexandra E. Rangel, Li A, Leighton Wan, Sharon J. Pitteri, Hyongsok Tom Soh, Trevor A. Feagin, Chun E, Moekl L, Michael Eisenstein, Alex M. Yoshikawa
Glycosylation is one of the most abundant forms of post-translational modification, and can have a profound impact on a wide range of biological processes and diseases. Unfortunately, efforts to characterize such modifications in the context of basic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::456d86d09980ec6cebba625dee164a3d
https://doi.org/10.1101/2021.03.13.435263
https://doi.org/10.1101/2021.03.13.435263
Autor:
Peter L. Mage, Trevor A. Feagin, Alexandra E. Rangel, Hyongsok Tom Soh, Leighton Wan, Diana Wu, John A. Coller, Sharon J. Pitteri, Michael Eisenstein, Li A
Summary Aptamers incorporating chemically modified bases can achieve superior affinity and specificity compared to natural aptamers, but their discovery remains a labor-intensive, low-throughput task. Here we describe the ‘non-natural aptamer array
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8f73a12ee9e0ed3de3a35806c57f1c
https://doi.org/10.1101/2020.04.25.060004
https://doi.org/10.1101/2020.04.25.060004
Publikováno v:
Nucleic Acids Research. 46:8057-8068
Despite advances in XNA evolution, the binding capabilities of artificial genetic polymers are currently limited to protein targets. Here, we describe the expansion of in vitro evolution techniques to enable selection of threose nucleic acid (TNA) ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8f4c22398c68471cad9790a8ac3ea7
https://doi.org/10.1093/nar/gky667
https://doi.org/10.1093/nar/gky667
Publikováno v:
Methods. 106:29-36
Nucleic acid aptamers have emerged as a promising alternative to antibodies for use as recognition elements in therapeutics, bioimaging, and analytical applications. A key benefit that aptamers possess relative to antibodies is their ability to be ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163c82ff001b37d720898aac8446a4dc
https://doi.org/10.1016/j.ymeth.2016.03.008
https://doi.org/10.1016/j.ymeth.2016.03.008
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(16)
Three β,γ-modified α-l-threofuranosyl nucleoside triphosphates were synthesized. The β,γ-modified tTTPs undergo a single incorporation event with HIV RT but undergo multiple incorporations to form full-length product with engineered thermophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a6a2ddecbcd51327a30835d98c0d5b
https://pubmed.ncbi.nlm.nih.gov/27422338
https://pubmed.ncbi.nlm.nih.gov/27422338
Autor:
Alexandra E. Rangel, Kirsten N. Meek, April J. Anamisis, Julie Hollien, Ashwani Sharma, Jennifer M. Heemstra, Joshua J. Plant
Publikováno v:
ACS chemical biology. 9(8)
The ability to fluorescently label specific RNA sequences is of significant utility for both in vitro and live cell applications. Currently, most RNA labeling methods utilize RNA-nucleic acid or RNA-protein molecular recognition. However, in the sear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b051091f36deabd26097274e64f417d
https://pubmed.ncbi.nlm.nih.gov/24896502
https://pubmed.ncbi.nlm.nih.gov/24896502