Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alexandra E. Conibear"'
Autor:
Alexandra E. Conibear, Eamonn Kelly
Publikováno v:
Mol Pharmacol
The field of biased agonism has grown substantially in recent years and the μ-opioid receptor has been one of the most intensively studied receptor targets for developing biased agonists. Yet, despite extensive research efforts, the development of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272bfffea7ac4b54c6dceeace6867c89
https://doi.org/10.1124/mol.119.115956
https://doi.org/10.1124/mol.119.115956
Autor:
Nina K Blum, Alexandra E. Conibear, Lawrence Toll, Christopher P Bailey, Sam Groom, Stefan Schulz, Andrea Kliewer, Yangmei Li, Robert J. Hill, Graeme Henderson, Stephen M. Husbands, Alexander Disney, Eamonn Kelly
Publikováno v:
Groom, S, Blum, N K, Conibear, A E, Disney, A, Hill, R, Husbands, S M, Li, Y, Toll, L, Kliewer, A, Schulz, S, Henderson, G, Kelly, E & Bailey, C P 2020, ' A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitization through G protein-coupled receptor kinase ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15334
Background and purpose G protein-biased μ opioid receptor agonists have the potential to induce less receptor desensitisation and tolerance than balanced opioids. Here, we investigated if the cyclic endomorphin analogue Tyr-c[D-Lys-Phe-Tyr-Gly] (Com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc648062a7130f11bcbd573241c38c74
https://purehost.bath.ac.uk/ws/files/214871251/Groom_et_al_Accepted_version_inc_figures.pdf
https://purehost.bath.ac.uk/ws/files/214871251/Groom_et_al_Accepted_version_inc_figures.pdf
Autor:
Alexandra E, Conibear, Junaid, Asghar, Rob, Hill, Graeme, Henderson, Eva, Borbely, Valeria, Tekus, Zsuzsanna, Helyes, Josephine, Palandri, Chris, Bailey, Ingemar, Starke, Bengt, von Mentzer, David, Kendall, Eamonn, Kelly
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Agonists at the δ opioid receptor are known to be potent antihyperalgesics in chronic pain models and effective in models of anxiety and depression. However, some δ opioid agonists have proconvulsant properties while tolerance to the therapeutic ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ca4495a6e2a0845669d1fa86960b59d
https://pubmed.ncbi.nlm.nih.gov/31594792
https://pubmed.ncbi.nlm.nih.gov/31594792